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101.
The inhibition of lung cancer cell growth by intracellular immunization with LC—1 ScFv 总被引:2,自引:0,他引:2
INTRODUCTIONLung cancer remains the leading cause of can-cer mortaIity in the world, accounting for more thanone sixth of cancer deaths in the world[1]. Antibod-ies have been proved to be a powerful tool fOr thestudy of 1ung cancer. A monoclonal IgM antibody,LC-1, was obtained in our laboratory. It can reactat a high rate with all four pathological types of lungcancers, including lung adenocarcinoma, 1ung squamous carcinoma, large cell lung cancer and smaIlcell lung cancert but not wit… 相似文献
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Diwen Liang George B. McManus Qing Wang Xian Sun Zhiwei Liu Senjie Lin Yufeng Yang 《Ecology and evolution》2022,12(5)
Genetic differentiations and phylogeographical patterns of small organisms may be shaped by spatial isolation, environmental gradients, and gene flow. However, knowledge about genetic differentiation of rotifers at the intercontinental scale is still limited. Polyarthra dolichoptera and P. vulgaris are cosmopolitan rotifers that are tolerant to environmental changes, offering an excellent model to address the research gap. Here, we investigated the populations in Southeastern China and eastern North America and evaluated the phylogeographical patterns from their geographical range sizes, geographic–genetic distance relationships and their responses to spatial‐environmental factors. Using the mitochondrial cytochrome c oxidase subunit I gene as the DNA marker, we analyzed a total of 170 individuals. Our results showed that some putative cryptic species, also known as entities were widely distributed, but most of them were limited to single areas. The divergence of P. dolichoptera and P. vulgaris indicated that gene flow between continents was limited while that within each continent was stronger. Oceanographic barriers do affect the phylogeographic pattern of rotifers in continental waters and serve to maintain genetic diversity in nature. The genetic distance of P. dolichoptera and P. vulgaris populations showed significant positive correlation with geographic distance. This might be due to the combined effects of habitat heterogeneity, long‐distance colonization, and oceanographic barriers. Furthermore, at the intercontinental scale, spatial distance had a stronger influence than environmental variables on the genetic differentiations of both populations. Wind‐ and animal‐mediated transport and even historical events of continental plate tectonics are potential factors for phylogeography of cosmopolitan rotifers. 相似文献
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Lubiao Liang Ran Sui Yongxiang Song Yajin Zhao 《Acta biochimica et biophysica Sinica》2021,(11):1558-1566
Tumor acidic microenvironment is the main feature of many solid tumors.As a part of the tumor microenvironment,it has a profound impact on the occurrence and de... 相似文献
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Yuanyong Feng Xuedi Cao Bin Zhao Chunyan Song Baoxing Pang Liang Hu Chunmei Zhang Jinsong wang Junqi He Songlin wang 《中国科学:生命科学英文版》2021,(11):1810-1828
Although cisplatin is one of the chemotherapeutics most frequently used in oral squamous cell carcinoma (OSCC) treatment,it exerts multiple side effects and poo... 相似文献
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Where risk factors have been identified in knee and hip osteoarthritis (OA), with few exceptions, no prevention strategies
have proven beneficial. The major risk factors for knee OA are advanced age, injury and obesity. However, there is limited
or no evidence that they are modifiable or to what degree modifying them is effective in preventing development of knee OA
or in preventing symptoms and progressive disease in persons with early OA. The notable exception is the growing epidemic
of (sports) injury related knee OA. This review details the biological and clinical data indicating the efficacy of interventions
targeting neuromuscular and biomechanical factors that make this subset of OA an attractive public health target, and highlights
research opportunities for the future. 相似文献