排序方式: 共有177条查询结果,搜索用时 15 毫秒
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David R. Nelson Khaled M. Hazzouri Kyle J. Lauersen Ashish Jaiswal Amphun Chaiboonchoe Alexandra Mystikou Weiqi Fu Sarah Daakour Bushra Dohai Amnah Alzahmi David Nobles Mark Hurd Julie Sexton Michael J. Preston Joan Blanchette Michael W. Lomas Khaled M.A. Amiri Kourosh Salehi-Ashtiani 《Cell host & microbe》2021,29(2):250-266.e8
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173.
Maryam Arabi Yousef Al-Najjar Nada Mhaimeed Mohammad A. Salameh Pradipta Paul Jamal AlAnni Ali A. Abdelati Ibrahim Laswi Bushra Khanjar Dana Al-Ali Abdallah Elshafeey Omar Mhaimeed Zain Burney Ashton D'Souza Pratyaksha Sinha Mohammad Bhatti Krishnadev V. Pillai Moayad Homssi Khalifa Bshesh Lina Yagan Dalia Zakaria 《Journal of cellular and molecular medicine》2023,27(11):1443-1464
The Omicron variant was first detected in October 2021, which evolved from the original SARS-CoV-2 strain and was found to possess many mutations. Immune evasion was one of the notable consequences of these mutations. Despite Omicron exhibiting increased transmissibility, the rates of hospitalizations and deaths among patients infected with this variant were substantially lower when compared to other strains. However, concluding that the Omicron variant is less severe than other variants of SARS-CoV-2 requires consideration of multiple factors, including the vaccination status of infected patients as well as any previous infections with other variants. This review compiled data about any reported indicators of severity in Omicron-infected patients, including studies comparing Omicron with other variants while adjusting for confounders. A comprehensive search was conducted using different databases to target any studies about Omicron. In total, 62 studies met our inclusion criteria and were included in this study. Many studies reported a significantly reduced risk of hospitalization, ICU admission, need for oxygenation/ventilation, and death in Omicron-infected patients compared to patients infected with other variants, such as Delta. Some studies, however, reported comparable severity in Omicron infected patients as to other variants emphasizing a substantial risk for severe illness. Furthermore, the COVID-19 vaccines were less effective against Omicron relative to previous lineages, except after receiving the booster dose. One study recommended vaccination during pregnancy, which may help prevent future cases of severe SARS-CoV-2 pneumonia in neonates and young infants due to the transfer of humoral response from the mother. 相似文献
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Carla Brillada Ooi-Kock Teh Franck Anicet Ditengou Chil-Woo Lee Till Klecker Bushra Saeed Giulia Furlan Marco Zietz Gerd Hause Lennart Eschen-Lippold Wolfgang Hoehenwarter Justin Lee Thomas Ott Marco Trujillo 《The Plant cell》2021,33(2):404
During the immune response, activation of the secretory pathway is key to mounting an effective response, while gauging its output is important to maintain cellular homeostasis. The Exo70 subunit of the exocyst functions as a spatiotemporal regulator by mediating numerous interactions with proteins and lipids. However, a molecular understanding of the exocyst regulation remains challenging. We show that, in Arabidopsis thaliana, Exo70B2 behaves as a bona fide exocyst subunit. Conversely, treatment with the salicylic acid (SA) defence hormone analog benzothiadiazole (BTH), or the immunogenic peptide flg22, induced Exo70B2 transport into the vacuole. We reveal that Exo70B2 interacts with AUTOPHAGY-RELATED PROTEIN 8 (ATG8) via two ATG8-interacting motives (AIMs) and its transport into the vacuole is dependent on autophagy. In line with its role in immunity, we discovered that Exo70B2 interacted with and was phosphorylated by the kinase MPK3. Mimicking phosphorylation had a dual impact on Exo70B2: first, by inhibiting localization at sites of active secretion, and second, it increased the interaction with ATG8. Phosphonull variants displayed higher effector-triggered immunity (ETI) and were hypersensitive to BTH, which induce secretion and autophagy. Our results suggest a molecular mechanism by which phosphorylation diverts Exo70B2 from the secretory into the autophagy pathway for its degradation, to dampen secretory activity.Phosphorylation of Exo70B2 inhibits PM interaction and increases interaction with ATG8, diverting Exo70B2 into the vacuole by autophagy, linking signalling and autophagy to secretion.The author(s) responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantcell.org) is: Marco Trujillo (ed.grubierf-inu.eigoloib@ollijurt.ocram). 相似文献
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Mohamed Bushra Elhassan M. Elhassan Naji I. Ali Elfatih Osman Khalid H. Bakheit Ishag I. Adam 《Biological trace element research》2010,137(3):255-261
Anaemia is a widespread problem in many parts of the world especially in tropic areas. Among pregnant women, it has negative
consequences on maternal and perinatal outcomes. A cross-sectional study was conducted to investigate the prevalence of anaemia,
iron, zinc and copper deficiencies among pregnant women in Wad Medani hospital, central Sudan and to examine the relationship
of these micronutrients with haemoglobin (Hb) levels. One hundred four (52.5%) out of 200 pregnant women had anaemia (Hb <
11 gm/dl) and 3 (1.5) % had severe anaemia (Hb < 7 gm/dl). Iron deficiency (S-ferritin < 15 μg/l), iron deficiency anaemia
(<11 gm/dl and S-ferritin < 15 μg/l) were prevalent in 25 (12.5%) and 13 (6.5%) of these women, respectively. Ninety (45.0%)
and eight (4.0%) of these women had zinc (<80 μg/ml) and copper (<80 μg/ml) deficiency, respectively. In 24 (12.0%) of these
women, there were ≥2 deficiencies of these elements. S-copper was significantly lower in patients with anaemia. While age,
parity, gestational age, ferritin, zinc and copper were not predictors for anaemia, women who practiced pica were at higher
risk for anaemia (OR = 3.4, 95% CI = 1.4–7.9, P = 0.004). Gestational age was significantly inversely correlated with haemoglobin (r = 0.161, P = 0.03), S-ferritin (r = 0.285, P = 0.001) and S-zinc (r = 0.166, P = 0.02). Thus, dietary and supplement interventions are required to prevent and control anaemia in this setting. Further research
is needed. 相似文献
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Arifa Tahir Rabia Shehzadi Bushra Mateen Saleh Univerdi Ozer Karacoban 《Engineering in Life Science》2009,9(6):462-467
In this study, Ni (II) biosorption capacity of immobilized cells of Bacillus sp. was investigated. Biosorption of Ni (II) was carried out in batch experiments and the important environmental conditions were optimized. The uptake of metal was rapid, and equilibrium was attained within 270 min. Bacillus strains (ten cultures) were isolated from nickel electroplating effluent by heat shock method. These isolates were grown up in nutrient broth supplemented with Ni (II)(50 mg/L). The culture, exhibiting maximum biosorption capacity (qmax: 118 mg/g), was selected and labeled Bacillus Bio‐4. In order to develop an economical biosorption process cell mass of Bacillus, Bio‐4 was immobilized in Na‐alginate. It was concluded from the results that biosorption of nickel is highly dependent on the type of sorbent and experimental conditions employed. Our results demonstrate that 6.0 mg immobilized cells (18 mg cell biomass in 3.0 mL of 1% Na alginate) had a maximum biosorption capacity of 113 mg Ni(II) per liter of suspension at pH 8.0, 100 rpm and 25°C. The Ni (II) removal was estimated to be 97.4%. 相似文献
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