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941.
D. Burton 《Journal of Zoology》1988,214(2):353-360
The melanophores associated with contrasting manifestations of ambicoloration in two species, winter flounder ( Pseudopleuronectes americanus ) and Greenland halibut ( Reinhardtius hippoglossoides ), from the Pleuronectidae are compared microscopically. Winter flounder is a benthic inshore species, whilst Greenland halibut is a deep water species considered to spend the greater part of its life away from the sea floor, although the relatively thick blind-side epidermis associated with a benthic life occurs in both species. Various forms of abnormal ambicoloration occur in some specimens of winter flounder. Melanophores from the flounder blind side are morphologically similar to those from the ocular side in the different forms of ambicoloration, although there are differences in melanophore densities. In Greenland halibut, ambicoloration is a normal characteristic which is considered to be secondarily acquired. The melanophores of the ocular side of Greenland halibut are similar to the melanophores of other Pleuronectidae, whereas those of the blind side are very different in morphology and size. 相似文献
942.
Deep Lake, a hypersaline lake of about ten times seawater concentration, rarely freezes and is characterized by a monomictic thermal cycle, Winter circulation, at c. –17 °C, lasts for two to three months. In summer, epilimnetic temperatures from 7–11 °C result in large vertical thermal gradients (21–26 °C) which combine with the enhanced rate of density change per degree Celsius, accompanying such high salt concentration, to produce a particularly stable density configuration in Deep Lake (Schmidt stability c. 8000 g-cm cm–2; 0.785 J cm–2). The Birgean annual heat budget (c. 24500 cal cm–2; 102.7 103 J cm–2) is comparable to that of a temperate lake with a similar mean depth, despite the comparatively high ratio of Birgean wind work to annual heat budget (0.37 g-cm cal–1). Deep lake retains c. 50% of the incident solar radiation during the short summer heating period; within the range estimated for first class lakes in North America. Extended daylight hours certainly contribute to the high maximum rate of heating in the lake (444 cal cm–2 day–1; 1.86 103 J cm–2 day–1). Deep Lake cools at a rate less than half its average heating rate. Partitioning the total stability into thermal and saline components shows that salinity can contribute up to c. 20% of the maximum summer Schmidt stability. In early summer, the effect of small melt-streams is to increase stability by diluting the epilimnion. In autumn, evaporative water loss can overtake this effect, creating small de-stabilizing salinity gradients. The usually short-term stabilizing influence of snowfall and drift is less predictable, but is probably more common in winter when strong winds are most frequent.Hypersalinity has a profound effect on the physical cycle of Deep Lake, through freezing point depression and the increased rate of density change with temperature. These changes affect the lake's biota, both in relation to osmotic stress, and by effectively exposing them to a more thermally extreme environment. A comparison between Deep Lake and a smaller lake of similar salinity (Lake Hunazoko, Skarvs Nes), demonstrates that it is inappropriate to consider the biological effects of salinity in isolation. The smaller lake offers warmer epilimnetic conditions for at least part of the summer, which may explain the much greater limnetic algal production in Lake Hunazoko. 相似文献
943.
Three surveys of cattle for bluetongue (BLU) antibody were conducted over the years 1978-1980 in coastal areas of New South Wales. In each survey the samples were identified by age. The prevalence of BLU-group antibody, demonstrated in a gel diffusion precipitin test, was highest in the north and decreased progressively to the south. Antibody prevalence increased with age. However, according to variations in prevalence by age and region, it was concluded that the activity of relevant viruses was highly variable between years and was geographically discontinuous. Evidence is presented that much of the antibody found, especially in animals less than 4 years old, failed to persist from one year to another. Factors likely to contribute to more persistent reactions in older animals are discussed. Neutralizing antibodies to bluetongue virus serotypes 1 and 21 were demonstrated and prevalence of these was associated with location and age, as was that of group-specific antibody. 相似文献
944.
D Bhatnagar A A Burton R Roskoski 《Biochemical and biophysical research communications》1988,156(2):801-806
Cyclic AMP-dependent protein kinase, which plays a major role in metabolic and genetic regulation, consists of two classes of isozymes denoted as type I and type II. The type II isozyme, moreover, consists of two subclasses denoted as neural and non-neural based upon immunochemical differences between the enzyme isolated from bovine brain and heart, respectively. Whereas the catalytic (C) subunits of these three isozymes are quite similar, all three isozymes differ with respect to their regulatory (R) subunits. In the present report, we have compared the sensitivities to cyclic AMP of the type I and type II isozymes in several tissues from a single species (rat). The sensitivities of the three isozymes to cyclic AMP were type I much greater than non-neural type II greater than neural type II. We suggest that the differences in sensitivity to cyclic AMP of isozymes present in the same cell provides the cell with a dynamic range of responses to the widely varying alterations in cellular cyclic AMP levels produced by regulatory first messengers. 相似文献
945.
Summary The breeding period of the Antarctic flea, Glaciopsyllus antarcticus (Smit and Dunnet), was synchronised with the breeding period of the host, Southern Fulmar (Fulmarus glacialoides Smith). Although eggs were laid in the host nest, larvae developed amongst the down (particularly on the belly) of host chicks. Larvae were blood feeders and pupated amongst the down of host chicks. The development of pupae was arrested by ambient temperatures (mean temperature of +2.5°C in January), but recommenced when pupae were warmed. Female fleas comprised 55.8% of a collection of 1988 adults. Low numbers of adult fleas were found in nests prior to host breeding and subsequent to host fledging in comparison to numbers on the host; adults are therefore presumed to overwinter on the host, remote from the nest. 相似文献
946.
Joseph G. Jardine Devin Sok Jean-Philippe Julien Bryan Briney Anita Sarkar Chi-Hui Liang Erin A. Scherer Carole J. Henry Dunand Yumiko Adachi Devan Diwanji Jessica Hsueh Meaghan Jones Oleksandr Kalyuzhniy Michael Kubitz Skye Spencer Matthias Pauthner Karen L. Saye-Francisco Fabian Sesterhenn Patrick C. Wilson Denise M. Galloway Robyn L. Stanfield Ian A. Wilson Dennis R. Burton William R. Schief 《PLoS pathogens》2016,12(8)
An optimal HIV vaccine should induce broadly neutralizing antibodies (bnAbs) that neutralize diverse viral strains and subtypes. However, potent bnAbs develop in only a small fraction of HIV-infected individuals, all contain rare features such as extensive mutation, insertions, deletions, and/or long complementarity-determining regions, and some are polyreactive, casting doubt on whether bnAbs to HIV can be reliably induced by vaccination. We engineered two potent VRC01-class bnAbs that minimized rare features. According to a quantitative features frequency analysis, the set of features for one of these minimally mutated bnAbs compared favorably with all 68 HIV bnAbs analyzed and was similar to antibodies elicited by common vaccines. This same minimally mutated bnAb lacked polyreactivity in four different assays. We then divided the minimal mutations into spatial clusters and dissected the epitope components interacting with those clusters, by mutational and crystallographic analyses coupled with neutralization assays. Finally, by synthesizing available data, we developed a working-concept boosting strategy to select the mutation clusters in a logical order following a germline-targeting prime. We have thus developed potent HIV bnAbs that may be more tractable vaccine goals compared to existing bnAbs, and we have proposed a strategy to elicit them. This reductionist approach to vaccine design, guided by antibody and antigen structure, could be applied to design candidate vaccines for other HIV bnAbs or protective Abs against other pathogens. 相似文献
947.
Suong T. Cu Timothy J. March Susan Stewart Sophia Degner Stewart Coventry Amanda Box Doug Stewart Birgitte Skadhauge Rachel A. Burton Geoffrey B. Fincher Jason Eglinton 《Molecular breeding : new strategies in plant improvement》2016,36(9):129
Quantitative trait loci (QTLs) associated with grain weight, grain width, kernel hardness and malting quality were mapped in a doubled haploid population derived from two elite Australian malting barley varieties, Navigator and Admiral. A total of 30 QTLs for grain weight, grain width and kernel hardness were identified in three environments, and 63 QTLs were identified for ten malting quality traits in two environments. Three malting quality traits, namely β-amylase, diastatic power and apparent attenuation limit, were mainly controlled by a QTL linked to the Bmy1 gene at the distal end of chromosome 4H encoding a β-amylase enzyme. Six other malting quality traits, namely α-amylase, soluble protein, Kolbach index, free amino-acid nitrogen, wort β-glucan and viscosity, had coincident QTL clustered on chromosomes 1HS, 4HS, 7HS and 7HL, which demonstrated the interdependence of these traits. There was a strong association between these malt quality QTL clusters on chromosomes 1HS and 7HL and the major QTL for kernel hardness, suggesting that the use of this trait to enable early selection for malting quality in breeding programs would be feasible. In contrast, the majority of QTLs for hot-water extract were not coincident with those identified for other malt quality traits, which suggested differences in the mechanism controlling this trait. Novel QTLs have been identified for kernel hardness on chromosomes 2HL and 7HL, hot-water extract on 7HL and wort β-glucan on 6HL, and the resulting markers may be useful for marker-assisted selection in breeding programs. 相似文献
948.
Front Cover: Multispectral optoacoustic and MRI coregistration for molecular imaging of orthotopic model of human glioblastoma (J. Biophotonics 7/2016)
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949.
Face recognition is used to prove identity across a wide variety of settings. Despite this, research consistently shows that people are typically rather poor at matching faces to photos. Some professional groups, such as police and passport officers, have been shown to perform just as poorly as the general public on standard tests of face recognition. However, face recognition skills are subject to wide individual variation, with some people showing exceptional ability—a group that has come to be known as ‘super-recognisers’. The Metropolitan Police Force (London) recruits ‘super-recognisers’ from within its ranks, for deployment on various identification tasks. Here we test four working super-recognisers from within this police force, and ask whether they are really able to perform at levels above control groups. We consistently find that the police ‘super-recognisers’ perform at well above normal levels on tests of unfamiliar and familiar face matching, with degraded as well as high quality images. Recruiting employees with high levels of skill in these areas, and allocating them to relevant tasks, is an efficient way to overcome some of the known difficulties associated with unfamiliar face recognition. 相似文献
950.
Gareth S. Parry Sue Burton Bethan Cox Dan W. Forman 《European Journal of Wildlife Research》2011,57(3):485-494
The importance of the marine environment to Eurasian otters is currently poorly understood. Wales is one of the few countries
where coastal activity has been recorded and an increase in marine otter sightings could indicate remarkable developments
within Welsh populations. The trophic niche of coastal otter populations around Pembrokeshire was investigated over a 12-month
period. Marine activity was more widespread than previously thought and marine prey formed the largest component of otter
diet, although, otters also consumed freshwater and terrestrial prey throughout the year. Otter diet was very diverse compared
to other European coastal populations and a spring contraction in trophic niche width coincided with the estimated timing
of breeding activity. Seasonal variation in prey composition was predominantly due to differences in the consumption of alternate
prey types. In areas where wetlands are fragmented and populations of freshwater fish are declining, the marine environment
may become an increasingly important habitat for otters. It is necessary to define the historical importance of coastal populations
to otter conservation. Coastal areas are often subject to pressure from human activities, so the impact of disturbance needs
to be assessed. Importantly, there is no verified otter survey method for coastal areas, so the use of marine habitat is likely
to be underestimated. 相似文献