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133.
J P Buonaccorsi 《Biometrics》1986,42(4):875-882
Optimal designs are obtained for the estimation of relative potency in a slope ratio assay. Three criteria are considered based on the asymptotic variance of the standard point estimator. Efficiency functions are derived and numerical examples are given. 相似文献
134.
JP Reyes A Huanosta-Gutiérrez A López-Rodríguez A Martínez-Torres 《Channels (Austin, Tex.)》2015,9(2):88-95
We studied the effects of mutations of positively charged amino acid residues in the pore of X. tropicalis TMEM16A calcium-activated chloride channels: K613E, K628E, K630E; R646E and R761E. The activation and deactivation kinetics were not affected, and only K613E showed a lower current density. K628E and R761E affect anion selectivity without affecting Na+ permeation, whereas K613E, R646E and the double mutant K613E + R646E affect anion selectivity and permeability to Na+. Furthermore, altered blockade by the chloride channel blockers anthracene-9-carboxylic acid (A-9-C), 4, 4''-Diisothiocyano-2,2''-stilbenedisulfonic acid (DIDS) and T16inh-A01 was observed. These results suggest the existence of 2 binding sites for anions within the pore at electrical distances of 0.3 and 0.5. These sites are also relevant for anion permeation and blockade. 相似文献
135.
We present methods for solving and making statistical inferences about marginal attack rates based on observed death rates for contemporaneous mortality factors. The general method of solution involves solving a system of nonlinear equations which depend in part on competition coefficients that express the outcome when more than one agent attacks the same host individual. For two factors, we present a detailed analysis of the effect of varying this competition coefficient. Statistical inferences are illustrated using standard large sample approximations (the delta method) and the bootstrap, which is a resampling technique. We also extend the results to allow inferences for k-values. 相似文献