AUTOPSY REPORTS OF PULMONARY CARCINOMA—Survey in Los Angeles County Hospital for 1951

Of the 1,972 deaths investigated by autopsy at the Los Angeles County Hospital in 1951, 64 were attributed to bronchogenic carcinoma. However, in some of these cases the protocols did not contain sufficient data to substantiate the diagnosis or the tissue specimens were not conclusive evidence.Although the survey left no doubt that the lung was the most common site of primary carcinoma in the series studied, a wider application of the findings is limited by the facts that patients with bronchogenic carcinoma are more likely than others to die in hospitals and that selection of cases for autopsy depends on the interest of the physician and the consent of the patient''s survivors.     

Gestational diabetes mellitus in a cynomolgus monkey with group A streptococcal metritis and hemolytic uremic syndrome.

Gestational diabetes mellitus was diagnosed retrospectively in a ten-year-old female cynomolgus monkey. The mother developed severe purulent group A streptococcal metritis resulting in fetal sepsis. After parturition, the mother died from signs consistent with hemolytic uremic syndrome.     

Effect of passive immunization against progesterone on its distribution in circulation and tissues of mice

Anti-progesterone monoclonal antibody, injected into mice 32 h after mating at a dose that blocks the establishment of pregnancy, produced a significant reduction in the concentration of progesterone in the ovary and uterus within 6 h after treatment. Uterine concentrations remained lower in treated compared with control animals for at least 24 h after injection. There was an associated transient increase in plasma LH and FSH concentrations, but there was no change in plasma prolactin values. The percentage of total progesterone in the circulation that was unbound was reduced after treatment, but the concentration of unbound progesterone was increased. Studies of antibody binding of steroid in the presence of uterine progesterone receptor protein showed that there was a stoichiometric relationship in the distribution of ligand between the two binders. The present findings suggest that the effects of passive immunization against progesterone are associated with perturbation of tissue concentrations of steroid in the target organ as a result of high antibody concentrations in the circulation.