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191.
Bayram Göçmen Konrad Mebert Bahadır Akman Mehmet Zülfü Yıldız Mehmet Anıl Oğuz 《Zoology in the Middle East.》2013,59(4):306-313
We report new localities and range extensions for four vipers from Turkey. The distribution of Montivipera wagneri is extended substantially southwards into Mu? province, showing that this species is not endemic to the Aras valley as previously stated in the literature. Similarly, an unverified photograph of Montivipera albizona from Erzincan province, at its currently known eastern limit, was confirmed with new material, and its range is extended substantially southwards to the Anamos (Nur) Mountains in Hatay province. Smaller range extensions are reported for Vipera ammodytes transcaucasiana and V. darevskii. 相似文献
192.
Three brothers, aged 17, 14 and 4 ye presented. Deficiency of glucose-6-phosphatase was associated with deficiency of acid maltase in one and debranching enzyme in the other. Enzyme analyses could not be performed in the youngest sibling. 相似文献
193.
Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions 总被引:3,自引:0,他引:3
Steven A. Altman Tomasz H. Zastawny Lisa Randers-Eichhorn Marco A. Cacciuttolo Steven A. Akman Miral Dizdaroglu Govind Rao 《Free radical biology & medicine》1995,19(6):897-902
Formation of DNA-protein crosslinks (DPCs) in mammalian cells upon treatment with iron or copper ions was investigated. Cultured murine hybridoma cells were treated with Fe(II) or Cu(II) ions by addition to the culture medium at various concentrations. Subsequently, chromatin samples were isolated from treated and control cells. Analyses of chromatin samples by gas chromatography/mass spectrometry after hydrolysis and derivatization revealed a significant increase over the background amount of 3-[(1,3-dihydro-2,4-dioxopyrimidin-5-yl)-methyl]-
-tyrosine (Thy-Tyr crosslink) in cells treated with Fe(II) ions in the concentration range of 0.01 to 1 mM. In contrast, Cu(II) ions at the same concentrations did not produce this DPC in cells. No DNA base damage was observed in cells treated with Cu(II) ions, either. Preincubation of cells with ascorbic acid or coincubation with dimethyl sulfoxide did not significantly alleviate the Fe(II) ion-mediated formation of DPCs. In addition, a modified fluorometric analysis of DNA unwinding assay was used to detect DPCs formed in cells. Fe(II) ions caused significant formation of DPCs, but Cu(II) ions did not. The nature of the Fe(II)-mediated DPCs suggests the involvement of the hydroxyl radical in their formation. The Thy-Tyr crosslink may contribute to pathological processes associated with free radical reactions. 相似文献