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排序方式: 共有338条查询结果,搜索用时 31 毫秒
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Histone F1 from rat thymus. Subfractionation and incorporation of [32P]phosphate in vitro 总被引:2,自引:2,他引:0
Four subfractions of histone F1 from rat thymus were obtained by preparative polyacrylamide-gel electrophoresis. These subfractions are closely related in primary structure but show marked differences in radioactivity when derived from rat thymus nuclei labelled in vitro with [(32)P]phosphate. 相似文献
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Steven D. Buckingham Yoshiaki Higashino David B. Sattelle 《Invertebrate neuroscience : IN》2009,9(2):85-89
The actions of benzodiazepines were studied on the responses to GABA of the fast coxal depressor (Df) motor neurone of the cockroach, Periplaneta americana. Ro5-4864, diazepam and clonazepam were investigated. Responses to GABA receptors were enhanced by both Ro5-4864 and diazepam,
whereas clonazepam, a potent-positive allosteric modulator of human GABA(A) receptors, was ineffective on the native insect
GABA receptors of the Df motor neurone. Thus, clear pharmacological differences exist between insect and mammalian native GABA-gated chloride channels
with respect to the actions of benzodiazepines. The results enhance our understanding of invertebrate GABA-gated chloride
channels which have recently proved important in (a) comparative studies aimed at identifying human allosteric drug-binding
sites and (b) understanding the actions of compounds used to control ectoparasites and insect crop pests. 相似文献
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S C Lummis S D Buckingham J J Rauh D B Sattelle 《Proceedings of the Royal Society of London. Series B, Containing papers of a Biological character. Royal Society (Great Britain)》1990,240(1297):97-106
The actions of the polychlorocycloalkane insecticide heptachlor, and its epoxide metabolite, were examined on GABA receptors in insects and vertebrates. Electrophysiological experiments on the cell body of the cockroach (Periplaneta americana) fast coxal depressor motor neuron (Df), and GABA-activated 36Cl- uptake experiments on microsacs prepared from cockroach ventral nerve cords showed that both heptachlor and heptachlor epoxide blocked functional GABA receptors. The block appeared to be non-competitive and was voltage-independent over the membrane potential range -75 mV to -110 mV. There was no significant difference between the potencies of heptachlor and heptachlor epoxide in the functional assays for insect GABA receptors. Both compounds inhibited [35S]-t-butylbicyclophosphorothionate [( 35S]TBPS) binding in insects and vertebrates. The findings provide further evidence for block of an insect GABA receptor/Cl- channel by the cyclodiene class of polychlorocycloalkanes, and reveal differences in the insecticide-[35S]TBPS binding site interactions of insects and vertebrates. 相似文献