全文获取类型
收费全文 | 124篇 |
免费 | 15篇 |
国内免费 | 1篇 |
出版年
2021年 | 3篇 |
2020年 | 3篇 |
2018年 | 1篇 |
2017年 | 2篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 6篇 |
2012年 | 7篇 |
2011年 | 6篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 5篇 |
2007年 | 7篇 |
2006年 | 4篇 |
2005年 | 3篇 |
2004年 | 3篇 |
2003年 | 4篇 |
2002年 | 2篇 |
2001年 | 5篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 4篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1986年 | 5篇 |
1985年 | 2篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1971年 | 3篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1968年 | 2篇 |
1967年 | 1篇 |
排序方式: 共有140条查询结果,搜索用时 250 毫秒
41.
42.
43.
44.
Abstract: The lacertid material from the locality of Herrlingen 8 (upper Oligocene, MP28) is described as a new species of the genus Plesiolacerta. The material is disarticulated and comprises isolated elements including parietal, frontal, maxilla and dentary. It can be assigned to a single species on the basis of the external surface ornamentation. This morphology is typical for the genus Plesiolacerta, but the material differs in detail from the type species P. lydekkeri. The most significant feature of the new species is that the occipital scute of the parietal bone is narrow, rectangular in shape and anteroposteriorly short. Hitherto, the last occurrence of this genus was in the lower Oligocene. This material represents the first evidence of the existence of this genus in the upper Oligocene. Therefore, our knowledge of its evolution is expanded by providing new data on its spatial and temporal ranges and morphology. This taxon has a much longer history than we thought. In addition, the Eocene species, P. lydekkeri, is reviewed here. P. lydekkeri shares the most lacertid synapomorphies and, given our present knowledge, Plesiolacerta is a taxon very close to or possibly within crown Lacertidae. The frontal and postorbitofrontal of Plesiolacerta are described for the first time. In view of the primitive morphology and early occurrence of Plesiolacerta, it seems that the feature of a longer anterior region of the frontal could be considered as a plesiomorphic feature within lacertid lizards, and the condition in Timon (approximately the same length) as derived. 相似文献
45.
Garbow JR Doherty JM Schugar RC Travers S Weber ML Wentz AE Ezenwajiaku N Cotter DG Brunt EM Crawford PA 《American journal of physiology. Gastrointestinal and liver physiology》2011,301(6):G956-G967
Nanotechnology is providing new and innovative means to detect, diagnose, and treat disease. In this regard, numerous nanoparticle-based approaches have been taken in an effort to develop an effective oral insulin therapy for the treatment of diabetes. This review summarizes efficacy data from studies that have evaluated oral insulin therapies in experimental models. Also provided here is an overview of the limited safety data that have been reported in these studies. To date, the most promising approaches for nanoparticle-based oral insulin therapy appear to involve the incorporation of insulin into complex multilayered nanoparticles that are mucoadhesive, biodegradable, biocompatible, and acid protected and into nanoparticles that are designed to take advantage of the vitamin B(12) uptake pathway. It is anticipated that the continued investigation and optimization of nanoparticle-based formulations for oral delivery of insulin will lead to a much sought-after noninvasive treatment for diabetes. Such investigations also may provide insight into the use of nanoparticle-based formulations for peptide- and protein-based oral treatment of other diseases and for various food-related purposes. 相似文献
46.
47.
Lee HY Huang Y Bruneau N Roll P Roberson ED Hermann M Quinn E Maas J Edwards R Ashizawa T Baykan B Bhatia K Bressman S Bruno MK Brunt ER Caraballo R Echenne B Fejerman N Frucht S Gurnett CA Hirsch E Houlden H Jankovic J Lee WL Lynch DR Mohammed S Müller U Nespeca MP Renner D Rochette J Rudolf G Saiki S Soong BW Swoboda KJ Tucker S Wood N Hanna M Bowcock AM Szepetowski P Fu YH Ptáček LJ 《Cell reports》2012,1(1):2-12
Paroxysmal Kinesigenic Dyskinesia with Infantile Convulsions (PKD/IC) is an episodic movement disorder with autosomal dominant inheritance and high penetrance, but the causative gene is unknown. We have now identified four truncating mutations involving the PRRT2 gene in the vast majority (24/25) of well characterized families with PKD/IC. PRRT2 truncating mutations were also detected in 28 of 78 additional families. The PRRT2 gene encodes a proline-rich transmembrane protein of unknown function that has been reported to interact with the t-SNARE, SNAP25. PRRT2 localizes to axons but not to dendritic processes in primary neuronal culture and mutants associated with PKD/IC lead to dramatically reduced PRRT2 protein levels leading ultimately to neuronal hyperexcitability that manifests in vivo as PKD/IC. 相似文献
48.
OLF Weyl MK Schirrmann JS Hargrove T Bodill ER Swartz 《African Journal of Aquatic Science》2017,42(4):359-365
Largemouth bass Micropterus salmoides are a popular North American angling species that was introduced into South Africa in 1928. To enhance the largemouth bass fisheries, Florida bass Micropterus floridanus were introduced into KwaZulu Natal, South Africa, in 1980. Knowledge on the status of M. floridanus in South Africa is required, because it lives longer and reaches larger sizes than M. salmoides, which may result in heightened impacts on native biota. Because M. floridanus are morphologically similar, but genetically distinct from M. salmoides, the distribution of this species was assessed by genetically screening 185 Micropterus sp. individuals sampled from 20 localities across South Africa using the mitochondrial ND2 gene. Individuals with mitochondrial DNA matching M. salmoides were recovered from 16 localities, whereas M. floridanus mitochondrial DNA was recovered from 13 localities. At nine localities (45%), the mitochondrial DNA of both species was detected. These results demonstrate M. floridanus dispersal to multiple sites across South Africa. 相似文献
49.
Steroid hormone regulation of the Achlya ambisexualis 85-kilodalton heat shock protein, a component of the Achlya steroid receptor complex. 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The steroid hormone antheridiol regulates sexual development in the fungus Achlya ambisexualis. Analyses of in vivo-labeled proteins from hormone-treated cells revealed that one of the characteristic antheridiol-induced proteins appeared to be very similar to the Achyla 85-kilodalton (kDa) heat shock protein. Analysis of in vitro translation products of RNA isolated from control, heat-shocked, or hormone-treated cells demonstrated an increased accumulation of mRNA encoding a similar 85-kDa protein in both the heat-shocked and hormone-treated cells. Northern (RNA) blot analyses with a Drosophila melanogaster hsp83 probe indicated that a mRNA species of approximately 2.8 kilobases was substantially enriched in both heat-shocked and hormone-treated cells. The monoclonal antibody AC88, which recognizes the non-hormone-binding component of the Achyla steroid receptor, cross-reacted with Achlya hsp85 in cytosols from heat-shocked cells. This monoclonal antibody also recognized both the hormone-induced and heat shock-induced 85-kDa in vitro translation products. Taken together, these data suggest that similar or identical 85-kDa proteins are independently regulated by the steroid hormone antheridiol and by heat shock and that this protein is part of the Achyla steroid receptor complex. Our results demonstrate that the association of hsp90 family proteins with steroid receptors observed in mammals and birds extends also to the eucaryotic microbes and suggest that this association may have evolved early in steroid-responsive systems. 相似文献
50.
Inhibitory effects of fluorocitrates on yeast mitochondria 总被引:1,自引:0,他引:1