全文获取类型
收费全文 | 169篇 |
免费 | 6篇 |
专业分类
175篇 |
出版年
2023年 | 1篇 |
2021年 | 7篇 |
2020年 | 4篇 |
2019年 | 2篇 |
2018年 | 5篇 |
2017年 | 2篇 |
2016年 | 5篇 |
2015年 | 9篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 12篇 |
2011年 | 11篇 |
2010年 | 15篇 |
2009年 | 9篇 |
2008年 | 6篇 |
2007年 | 4篇 |
2006年 | 10篇 |
2005年 | 10篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 3篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 4篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1976年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有175条查询结果,搜索用时 0 毫秒
21.
R. W. M. Brouwers V. J. G. Houben J. J. Kraal R. F. Spee H. M. C. Kemps 《Netherlands heart journal》2021,29(3):151
BackgroundDespite proven clinical benefits, only a minority of patients complete outpatient cardiac rehabilitation (CR) after acute myocardial infarction (AMI). The main purpose of this study was to evaluate to what extent and at which time patients drop out of CR, and to assess which patient-related characteristics can predict dropout.MethodsIn a retrospective cohort study, we selected patients who had been hospitalised with an AMI in our centre in 2015 or 2016. Patients were selected pseudonymously based on reimbursement codes in the electronic health record. We extracted baseline characteristics and data on CR referral, enrolment and completion for each patient. Multivariable logistic regression was used to assess which characteristics predicted referral and dropout.ResultsThe 666 patients included were predominantly male (66%), with a mean age of 69.0 years. Of the 640 eligible patients, 201 (31%) were not referred for CR. Enrolment after referral was 94%. Nonreferral was independently associated with older age, female sex, traveling distance, non-ST-elevation myocardial infarction (NSTEMI; as compared with STEMI), no coronary revascularisation and prior manifestations of coronary artery disease. Of the 414 enrolled patients, 24% did not complete their CR programmes (i.e. dropped out). Older age and worse exercise capacity at baseline were independently associated with dropout. The ability of the multiple regression models to predict nonreferral and noncompletion was good to fair, with an area under the receiver operating characteristic curves of 0.86 and 0.71, respectively.ConclusionThe main reason for not participating in or not completing CR after AMI was nonreferral. To optimise CR utilisation, improvement of referral rates should be prioritised. 相似文献
22.
23.
H. M. C. Kemps R. W. M. Brouwers M. J. Cramer H. T. Jorstad E. P. de Kluiver R. A. Kraaijenhagen P. M. J. C. Kuijpers M. R. van der Linde E. de Melker S. F. Rodrigo R. F. Spee M. Sunamura T. Vromen M. E. Wittekoek 《Netherlands heart journal》2020,28(7):387-390
The ongoing coronavirus disease 2019 (COVID-19) crisis is having a large impact on acute and chronic cardiac care. Due to public health measures and t 相似文献
24.
Tobe SW Stone JA Brouwers M Bhattacharyya O Walker KM Dawes M Genest J Grover S Gubitz G Lau D Pipe A Selby P Tremblay MS Warburton DE Ward R Woo V Leiter LA Liu PP 《CMAJ》2011,183(15):E1135-E1150
25.
Usdin K; Chevret P; Catzeflis FM; Verona R; Furano AV 《Molecular biology and evolution》1995,12(1):73-82
The single most difficult problem in phylogenetic analysis is deciding
whether a shared taxonomic character is due to common ancestry or one that
appeared independently due to convergence, parallelism, or reversion to an
ancestral state. Mammalian L1 retrotransposons undergo periodic
amplifications in which multiple copies of the elements are interspersed in
the genome. Because these elements apparently are transmitted only by
inheritance and are retained in the genome, a shared L1 amplification event
can only be an inherited ancestral character. We propose that L1
amplification events can be an excellent tool for analyzing mammalian
evolution and demonstrate here how we addressed several refractory problems
in rodent systematics using L1 DNA as a taxonomic character.
相似文献
26.
Aike Jeucken J. Bernd Helms Jos F. Brouwers 《Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids》2018,1863(10):1345-1353
E. coli has three Cls-isoenzymes for cardiolipin (CL) synthesis but the differences between these three enzymes remain unresolved. All three Cls enzymes contain the phospholipase D (PLD) characteristic HKD motive and synthesize CL using PLD activity. Here, using LC-MS we show the effect of overexpressing or deletion of the three individual Cls enzymes on the lipidome, which included changes in lipid class distribution and CL species profiles. We demonstrate, for the first time, that overexpression of only ClsB resulted in the appreciable synthesis of a variety of phosphatidylalcohols, thereby establishing a ‘classic’ PLD activity for this enzyme: phospholipid headgroup exchange. Endogenous E. coli lipids and primary alcohols were substrates for this trans-phosphatidylation reaction. Furthermore, we show that endogenous levels of ClsA mediated a similar trans-phosphatidylation reaction to form phosphatidylalcohols, however this reaction was dependent on the presence of the foreign phospholipid class phosphatidylcholine (PC). This allows us to clarify the different specificities of the cardiolipin synthases. 相似文献
27.
Dimitri Pirottin Dominique Poncelet Luc Grobet Luis José Royo Benoit Brouwers Julio Masabanda Haruko Takeda Ruedi Fries Yoshikazu Sugimoto James E. Womack Susana Dunner Michel Georges 《Mammalian genome》1999,10(3):289-293
A closed YAC contig spanning the mh locus was assembled by STS content mapping with seven microsatellite markers, eight genes or EST, and nine STS corresponding
to YAC ends. The contig comprises 27 YACs, has an average depth of 4.3 YACs, and spans an estimated 1.2 Mb. A linkage map
was constructed based on five of the microsatellite markers anchored to the contig and shown to span 7 cM, yielding a ratio
of 160 kb/1 cM for the corresponding chromosome region. Comparative mapping data indicate that the constructed contig spans
an evolutionary breakpoint connecting two chromosome segments that are syntenic but not adjacent in the human. Consolidation
of human gene order by means of whole genome radiation hybrids and its comparison with the bovine order as inferred from the
contig confirm conservation of gene order within segments.
Received: 6 August 1998 / Accepted: 28 October 1998 相似文献
28.
Gunnel Hellgren Björn Andersson Andreas FM Nierop Jovanna Dahlgren Ze'ev Hochberg Kerstin Albertsson-Wikland 《Proteome science》2008,6(1):35
Background
The broad range in growth observed in short prepubertal children receiving the same growth hormone (GH) dose is due to individual variation in GH responsiveness. This study used a pharmaco-proteomic approach in order to identify novel biomarkers that discriminate between short non-GH-deficient (GHD) children who show a good or poor growth response to GH treatment. 相似文献29.
Ana M. Vacaru Fikadu G. Tafesse Philipp Ternes Vangelis Kondylis Martin Hermansson Jos F.H.M. Brouwers Pentti Somerharju Catherine Rabouille Joost C.M. Holthuis 《The Journal of cell biology》2009,185(6):1013-1027
Ceramides are central intermediates of sphingolipid metabolism with critical functions in cell organization and survival. They are synthesized on the cytosolic surface of the endoplasmic reticulum (ER) and transported by ceramide transfer protein to the Golgi for conversion to sphingomyelin (SM) by SM synthase SMS1. In this study, we report the identification of an SMS1-related (SMSr) enzyme, which catalyses the synthesis of the SM analogue ceramide phosphoethanolamine (CPE) in the ER lumen. Strikingly, SMSr produces only trace amounts of CPE, i.e., 300-fold less than SMS1-derived SM. Nevertheless, blocking its catalytic activity causes a substantial rise in ER ceramide levels and a structural collapse of the early secretory pathway. We find that the latter phenotype is not caused by depletion of CPE but rather a consequence of ceramide accumulation in the ER. Our results establish SMSr as a key regulator of ceramide homeostasis that seems to operate as a sensor rather than a converter of ceramides in the ER. 相似文献
30.
Sina Babazadeh Matthew L Broadhead John L Slavin Peter FM Choong 《International Seminars in Surgical Oncology : ISSO》2009,6(1):18
A presacral mass can present a diagnostic dilemma for the surgical oncologist. Differential diagnoses include congenital causes such as teratoma or chordoma, neurological causes such as neurilemoma or neurofibroma or other malignancies such as lymphoma or sarcoma. Diagnosis usually requires imaging such as CT and MRI and tissue biopsy. We present an unusual cause of a presacral mass being extramedullary haematopoiesis, found incidentally in a 71 year old female. Extramedullary haematopoiesis is defined as the production of myeloid and erythroid elements outside of the bone-marrow. This diagnosis is extremely rare in the presacral area especially in a patient with no haematological abnormalities. A review of the literature is presented. 相似文献