全文获取类型
收费全文 | 434篇 |
免费 | 28篇 |
专业分类
462篇 |
出版年
2023年 | 3篇 |
2022年 | 6篇 |
2021年 | 6篇 |
2020年 | 4篇 |
2019年 | 9篇 |
2018年 | 3篇 |
2017年 | 9篇 |
2016年 | 11篇 |
2015年 | 17篇 |
2014年 | 12篇 |
2013年 | 30篇 |
2012年 | 18篇 |
2011年 | 17篇 |
2010年 | 13篇 |
2009年 | 12篇 |
2008年 | 15篇 |
2007年 | 11篇 |
2006年 | 18篇 |
2005年 | 11篇 |
2004年 | 12篇 |
2003年 | 16篇 |
2002年 | 7篇 |
2001年 | 23篇 |
2000年 | 19篇 |
1999年 | 13篇 |
1998年 | 16篇 |
1997年 | 5篇 |
1996年 | 7篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 3篇 |
1986年 | 8篇 |
1985年 | 9篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1974年 | 4篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1957年 | 2篇 |
1945年 | 2篇 |
排序方式: 共有462条查询结果,搜索用时 0 毫秒
71.
72.
73.
Kathleen Woodruff Teresa Defrancesco Sandra Tou Christina M. Williams Mathew Breen Kathryn Meurs Bruce Keene Ke Cheng 《Journal of cellular and molecular medicine》2017,21(8):1503-1512
Cardiosphere‐derived cells (CDCs) have been shown to reduce scar size and increase viable myocardium in human patients with mild/moderate myocardial infarction. Studies in rodent models suggest that CDC therapy may confer therapeutic benefits in patients with non‐ischaemic dilated cardiomyopathy (DCM). We sought to determine the safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM. Canine CDCs (cCDCs) were grown from a donor dog heart. Similar to human CDCs, cCDCs express CD105 and are slightly positive for c‐kit and CD90. Thirty million of allogeneic cCDCs was infused into the coronary vessels of Doberman pinscher dogs with spontaneous DCM. Adverse events were closely monitored, and cardiac functions were measured by echocardiography. No adverse events occurred during and after cell infusion. Histology on dog hearts (after natural death) revealed no sign of immune rejection from the transplanted cells. 相似文献
74.
Background
OMA is a project that aims to identify orthologs within publicly available, complete genomes. With 657 genomes analyzed to date, OMA is one of the largest projects of its kind. 相似文献75.
76.
77.
Diana O Rios‐Szwed Hironori Suzuki Andreas Kniss Frank Löhr Soichi Wakatsuki Volker Dötsch Ivan Dikic Renwick CJ Dobson David G McEwan 《EMBO reports》2017,18(8):1382-1396
Through the canonical LC3 interaction motif (LIR), [W/F/Y]‐X1‐X2‐[I/L/V], protein complexes are recruited to autophagosomes to perform their functions as either autophagy adaptors or receptors. How these adaptors/receptors selectively interact with either LC3 or GABARAP families remains unclear. Herein, we determine the range of selectivity of 30 known core LIR motifs towards individual LC3s and GABARAPs. From these, we define a I nteraction 相似文献
78.
79.
A case of scientific fraud 总被引:1,自引:0,他引:1
80.
Lannie Ligthart Jouke-Jan Hottenga Cathryn M. Lewis Anne E. Farmer Ian W. Craig Gerome Breen Gonneke Willemsen Jacqueline M. Vink Christel M. Middeldorp Enda M. Byrne Andrew C. Heath Pamela A. F. Madden Michele L. Pergadia Grant W. Montgomery Nicholas G. Martin Brenda W. J. H. Penninx Peter McGuffin Dorret I. Boomsma Dale R. Nyholt 《Human genetics》2014,133(2):173-186
Migraine and major depressive disorder (MDD) are comorbid, moderately heritable and to some extent influenced by the same genes. In a previous paper, we suggested the possibility of causality (one trait causing the other) underlying this comorbidity. We present a new application of polygenic (genetic risk) score analysis to investigate the mechanisms underlying the genetic overlap of migraine and MDD. Genetic risk scores were constructed based on data from two discovery samples in which genome-wide association analyses (GWA) were performed for migraine and MDD, respectively. The Australian Twin Migraine GWA study (N = 6,350) included 2,825 migraine cases and 3,525 controls, 805 of whom met the diagnostic criteria for MDD. The RADIANT GWA study (N = 3,230) included 1,636 MDD cases and 1,594 controls. Genetic risk scores for migraine and for MDD were used to predict pure and comorbid forms of migraine and MDD in an independent Dutch target sample (NTR–NESDA, N = 2,966), which included 1,476 MDD cases and 1,058 migraine cases (723 of these individuals had both disorders concurrently). The observed patterns of prediction suggest that the ‘pure’ forms of migraine and MDD are genetically distinct disorders. The subgroup of individuals with comorbid MDD and migraine were genetically most similar to MDD patients. These results indicate that in at least a subset of migraine patients with MDD, migraine may be a symptom or consequence of MDD. 相似文献