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31.
Eric AF Simoes 《Respiratory research》2002,3(1):6
In sarcoidosis, host genetic factors are discussed as contributing to disease susceptibility and course. Since tumor necrosis factor (TNF)-α is a central mediator of granuloma formation and since elevated TNF-α levels are found during active phases of sarcoidosis, genetic polymorphisms correlating with influences on TNF-α levels are of special interest. The complete sequencing of the MHC region and the increase in the number of identified gene polymorphisms in this locus associated with TNF-α production offer the opportunity of detecting new genes associated with sarcoidosis and perhaps of defining disease-associated haplotypes that bear the potential of serving as predictive markers for this disease. 相似文献
32.
Cardiomyogenic differentiation of human adipose‐derived mesenchymal stem cells transduced with Tbx20‐encoding lentiviral vectors 下载免费PDF全文
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Clare B. O’Donovan Marianne C. Walsh Hannah Forster Clara Woolhead Carlos Celis-Morales Rosalind Fallaize Anna L. Macready Cyril F. M. Marsaux Santiago Navas-Carretero Rodrigo San-Cristobal Silvia Kolossa Christina Mavrogianni Christina P. Lambrinou George Moschonis Magdalena Godlewska Agnieszka Surwillo Jildau Bouwman Keith Grimaldi Iwona Traczyk Christian A. Drevon Hannelore Daniel Yannis Manios J. Alfredo Martinez Wim H. M. Saris Julie A. Lovegrove John C. Mathers Michael J. Gibney Lorraine Brennan Eileen R. Gibney 《Genes & nutrition》2016,11(1):25
Background
It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n?=?178) or non-risk (CC) (n?=?141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention.Results
There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p?=?0.010). Baseline folate intakes were 412?±?172, 391?±?190 and 410?±?186 μg per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate.Conclusions
These results suggest that knowledge of MTHFR 677C?→?T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant.Trial registration
ClinicalTrials.gov NCT0153013934.
Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study 下载免费PDF全文
Carlos Celis‐Morales Cyril F.M. Marsaux Katherine M. Livingstone Santiago Navas‐Carretero Rodrigo San‐Cristobal Clare B. O'donovan Hannah Forster Clara Woolhead Rosalind Fallaize Anna L. Macready Silvia Kolossa Jacqueline Hallmann Lydia Tsirigoti Christina P. Lambrinou George Moschonis Magdalena Godlewska Agnieszka Surwio Keith Grimaldi Jildau Bouwman Yannis Manios Iwona Traczyk Christian A. Drevon Laurence D. Parnell Hannelore Daniel Eileen R. Gibney Lorraine Brennan Marianne C. Walsh Mike Gibney Julie A. Lovegrove J. Alfredo Martinez Wim H.M. Saris John C. Mathers 《Obesity (Silver Spring, Md.)》2016,24(4):962-969
35.
36.
Protein acetylation affects acetate metabolism,motility and acid stress response in
Escherichia coli 下载免费PDF全文
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38.
Rijke, A.M., Jesser, W.A., Evans, S.W & Bouwman, H. 2000. Water repellency and feather structure of the Blue Swallow Hirundo atrocaerulea. Ostrich 71 (1 & 2): 143–145. The Blue Swallow is an endangered species in southern Africa and is probably the most endangered passerine. It is restricted to escarpments with grasslands above 1 000 m where mists are frequent. It appears to forage on the wing even in thick mist raising the question of feather wettability in relation to its adaptation. Extensive physical and behaviourial adaptations are known to occur in a wide variety of birds to deal with the problem of shedding water continuously. To study the water repellency and resistance to water penetration of Blue Swallow feathers, we have examined the microscopic structure of head, back, throat, breast and abdominal feathers as well as remiges and tail feathers by transmission light microscopy. The width (2R) and separation (2D) of rami and barbules have been measured and were used to calculate the parameter (R + D)/R that serves as an indicator ofwater shedding potential. For the remiges and tail feathers the values of the (R+D)/R range from 5 to 10 which is comparable to values for other terrestrial birds. However, for body feathers the range is from 10 (head) and 35 (abdomen)-higher than previously observed for any other bird including Swifts, Apodidae. Blue Swallow feathers are thus the most effective feather yet discovered at repelling water drops. The water repellency is highest in those feathers that are relatively shielded From the direct impact of small water drops (throat, breast, abdomen, back). By contrast, the flight feathers must possess a relatively large resistance to water penetration to avoid becoming waterlogged and this is coupled to low (R+D)/R values. Values for the barbules lay between 2 and 6—the same as found for other bird families—supporting an earlier conclusion that they have little direct effect in repelling water. 相似文献
39.
A. F. Bouwman A. H. W. Beusen J. Griffioen J. W. Van Groenigen M. M. Hefting O. Oenema P. J. T. M. Van Puijenbroek S. Seitzinger C. P. Slomp E. Stehfest 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2013,368(1621)
Soil nitrogen (N) budgets are used in a global, distributed flow-path model with 0.5° × 0.5° resolution, representing denitrification and N2O emissions from soils, groundwater and riparian zones for the period 1900–2000 and scenarios for the period 2000–2050 based on the Millennium Ecosystem Assessment. Total agricultural and natural N inputs from N fertilizers, animal manure, biological N2 fixation and atmospheric N deposition increased from 155 to 345 Tg N yr−1 (Tg = teragram; 1 Tg = 1012 g) between 1900 and 2000. Depending on the scenario, inputs are estimated to further increase to 408–510 Tg N yr−1 by 2050. In the period 1900–2000, the soil N budget surplus (inputs minus withdrawal by plants) increased from 118 to 202 Tg yr−1, and this may remain stable or further increase to 275 Tg yr−1 by 2050, depending on the scenario. N2 production from denitrification increased from 52 to 96 Tg yr−1 between 1900 and 2000, and N2O–N emissions from 10 to 12 Tg N yr−1. The scenarios foresee a further increase to 142 Tg N2–N and 16 Tg N2O–N yr−1 by 2050. Our results indicate that riparian buffer zones are an important source of N2O contributing an estimated 0.9 Tg N2O–N yr−1 in 2000. Soils are key sites for denitrification and are much more important than groundwater and riparian zones in controlling the N flow to rivers and the oceans. 相似文献
40.
Motalaotte, S. & Bouwman, H. 2000. Pesticide levels in stork and spoonbill eggs from the Okavango Delta, Botswana. Ostrich 71 (1&2):344. Ecotourism in the Okavango Delta is one of the major sources of foreign revenue for the Republic of Botswana. Promoting this region is therefore vital to sustainable development. One of the concerns was the past use of organochlorine pesticides to combat tsetse fly. This study looked at the levels and possible risk this use poses to Marabou storks and African Spoonbills, as well as some other birds, from this region. One particular breeding colony also experienced a decline in breeding success, the cause of which is unknown. DDE was present in almost all the eggs and blood sampled, while DDD, DDT and Dieldrin were also found in many. These pesticides are therefore present in the food chain and should be closely monitored to determine any temporal trends. 相似文献