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1.
An perfusion system was used to assess the effects of chloride channel blockers, dopamine (DA) receptor agonists and antagonists, and GABA receptor agonists and antagonists on prolactin release from the mouse anterior pituitary. Dopamine and muscimol inhibited prolactin release ( respectively). The GABA receptor antagonist bicuculline blocked the inhibition of prolactin release by muscimol but not dopamine. The dopamine receptor antagonist chlorpromazine blocked the dopamine- but not muscimol-induced inhibition of prolactin release. Haloperidol, however, reversed both the muscimol and dopamine induced inhibition of prolactin release. Furthermore, the chloride channel blocker picrotoxinin blocked the inhibition of prolactin release elicited by both dopamine and muscimol. These later results suggest that the anterior pituitary dopamine receptor which mediates the inhibition of prolactin release may be coupled to a picrotoxinin sensitive chloride ionophore and that haloperidol may affect the function of both DA and GABA receptors in the anterior pituitary. 相似文献
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Boris Blumenstein Isaac Breslav Michael Bar-Eli Gershon Tenenbaum Yitzhak Weinstein 《Applied psychophysiology and biofeedback》1995,20(2):169-183
The purpose of the present study was to examine whether breathing pattern may be used as a reliable index for the effectiveness of techniques applied for the regulation of mental states. Heart rate (HR), breathing pattern, galvanic skin response (GSR), and electromyogram (EMG) of the frontalis muscle were measured in 39 male and female subjects aged 18–25 years during 10-minute treatment with relaxation technique (autogenic training and/or music) followed by 10 minutes of imagery training. In the first 7 sessions biofeedback (BFB) was not included, while during the last 6 sessions BFB was introduced and utilized by the subjects. Relaxation (music or autogenic training) led to a decrease in breathing frequency, attributed to lengthening of expiration time, as well as reduced HR, GSR, and frontalis EMG response. In most instances imagery training was related to an increase in these indices. Specifically, significant tachypnea was observed during imagery of sprint running. In most cases BFB substantially augmented the physiological responses. In conclusion, our data suggest that, compared with HR, GSR, and EMG responses, the breathing pattern is at least as sensitive to the mental techniques employed, and may be useful as a psychophysiological index for diagnosis and testing, especially in sport practice. 相似文献
4.
Boris Culik 《Polar Biology》1994,14(3):205-210
Energy requirements of resting Adélie (Pygoscelis adeliae), Gentoo (P. papua) and Chinstrap (P. antarcticd) penguin chicks were determined with respect to body mass via respirometry in Antarctica. Resting metabolic rates of all Pygoscelid penguin chicks were similar (ANOVA p=0.91) and best described by E=0.0096 M0.98 (n=24, r2=0.97), where E is power (W) and M is mass (g). Using the results obtained here and data published in the literature, I determined a) the amount of food needed from hatching to fledging as 29.8, 31.7 and 56.4 kg per chick for Adélie, Chinstrap and Gentoo penguins, respectively and b) the average amount of food left daily to the parent after feeding the brood throughout the breeding period. Parents keep only a minimum of food for themselves just prior to the time when chicks begin forming crèches. Thereafter, nest relief intervals are increased, and the amount of food parents can keep for themselves rises. The results of both models are discussed with respect to available data on Pygoscelid penguin food requirements. 相似文献
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Sarah Grant Andreas Houben Boris Vyskot Jiri Siroky Wei-Hua Pan Jiri Macas Heinz Saedler 《Genesis (New York, N.Y. : 2000)》1994,15(3):214-230
Most flowering plant species are hermaphroditic, but a small number of species in most plant families are unisexual (i.e., an individ-ual will produce only male or female gametes). Because species with unisexual flowers have evolved repeatedly from hermaphroditic progenitors, the mechanisms controlling sex determination in flowering plants are extremely diverse. Sex is most strongly determined by genotype in all species but the mechanisms range from a single controlling locus to sex chromosomes bearing several linked locirequired for sex determination. Plant hormones also influence sex expression with variable effects from species to species. Here, we review the genetic control of sex determination from a number of plant species to illustrate the variety of extant mechanisms. We emphasize species that are now used as models to investigate the molecular biology of sex determination. We also present our own investigations of the structure of plant sex chromosomes of white campion (Silene latifolia - Melan-drium album). The cytogenetic basis of sex determination in white campion is similar to mammals in that it has a male-specific Y-chromosome that carries dominant male determining genes. If one copy of this chromosome is in the genome, the plant is male. Otherwise it is female. Like mammalian Y-chromosomes, the white campion Y-chromosome is rich in repetitive DNA. We isolated repetitive sequences from microdissected Y-chromosomes of white campion to study the distribution of homologous repeated sequences on the Y-chromosome and the other chromosomes. We found the Y to be especially rich in repetitive sequences that were generally dispersed over all the white campion chromosomes. Despite its repetitive character, the Y-chromosome is mainly euchromatic. This may be due to the relatively recent evolution of the white campion sex chromosomes compared to the sex chromosomes of animals. © 1994 Wiley-Liss, Inc. 相似文献
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Andrei G. Pakhomov Boris V. Dubovick Igor G. Degtyariov Anatoly N. Pronkevich 《Bioelectromagnetics》1995,16(4):250-254
The combined effects of microwave radiation and some drugs were studied in an isolated frog auricle preparation. The experiments established that exposure to pulse-modulated 915 MHz microwaves for up to 40 min had no effect on either the rate or the amplitude of spontaneous auricle twitches, unless the average absorbed power was high enough to produce preparation heating. Treatment of the preparation with saline containing (0.6–3.0) 10?5 M of propranolol or (0.5–1.5) 10?7 M of atropine altered neither its pacemaker nor its contractile functions; these drugs also had no effect when they were combined with nonthermal microwave irradiation. Caffeine (1 mM) strongly increased the average heart power, which was calculated as the product of twitch rate and amplitude. The caffeine effect appeared to be significantly augmented (by about 15%, P<0.02) under exposure to burst-type pulsed microwaves (pulse width, 1.5 msec; pause, 2.5 msec; 8 pulses/burst, 16 bursts/s; average SAR, 8–10 W/kg). By itself, this modulation was not effective; the heating of the preparation and saline during exposure was approximately 0.1°C, which could not account for the detected changes. The experimental results demonstrate that caffeine treatment increases the microwave sensitivity of the frog auricle preparation and reveals primarily subthreshold, nonthermal microwave effect. © 1995 Wiley-Liss, Inc. 相似文献
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Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components analyzed — hydrocortisone-resistant thymocytes, splenic T and B lymphocytes, macrophages and bone-marrow cells — expressed H-2K-subregion-encoded alloantigens at a high density, it seems that the high density expression of H-2D-encoded alloantigens is restricted mainly to B cells and to macrophages. Hydrocortisone-resistant thymocytes, splenic T lymphocytes and bone-marrow cells, on the other hand, showed significant expression of the H-2D alloantigens only at low membrane density. These results, then, provide evidence for the existence of an imbalance in serologically detectable expression of H-2K- and H-2D-region-gene products on the cell membrane of various cells comprising the murine immune system.Abbreviations usedin this paper DTH
delayed type hypersensitivity
- FCS
fetal calf serum
- FITC
fluorescein isothiocyanate
- HrT
hydrocortisone-resistant thymocytes
- Ig
immunoglobulins
P. De Baetselier is an EMBO and Euratom postdoctoral fellow 相似文献
10.
Svetlana V. Butsuk Boris I. Bessonov 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1981,141(2):277-282
Summary A direct current electric field up to 3 mV/ cm was recorded in 33 sea water around the fishMyoxocephalus brandti, Hexogrammos octogrammos, Enophrys diceraus, Pleuronectes stellatus, Bathimaste r derjugini, Sebastes scorpaeniformis. The body surface potentials were positive in relation to the external and internal media; they attained 10 mV and slowly varied near the mean value at every point. The potentials at the surface points of individual skin sections adjoining the oral and branchial cavities, the anal orifice and peripheral fin sections were normally characterized by polarities opposite to those of body surface potentials (in sea water they were negative in relation to the external medium).When placed in sea water during their fresh water cycle, the salmonOncorhynchus keta and the fresh water fishSalvelinus alpinus andMisgurnus fossilis had no d.c. field.In fresh water containing less than 0.03 salt, a d.c. field up to 25 mV/cm was recorded around all the above mentioned species. The potentials had an opposite polarity to that recorded in sea water.The distribution of potentials over the fish surface depends on the species. The potentials at some points of the body surfaces were found to vary when other fish or metal objects were placed in the aquarium.The parameters of the direct current electric field generated by a whole fish and by isolated skin pieces were identical and varied by the same law with changed medium salinity. Thus it may be assumed that the d.c. electric field around the fish is produced by active electrogenic ion transport mechanisms localized in the skin. 相似文献