全文获取类型
收费全文 | 83篇 |
免费 | 2篇 |
专业分类
85篇 |
出版年
2022年 | 2篇 |
2021年 | 4篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2015年 | 4篇 |
2014年 | 2篇 |
2013年 | 6篇 |
2012年 | 6篇 |
2011年 | 5篇 |
2010年 | 6篇 |
2009年 | 3篇 |
2008年 | 4篇 |
2007年 | 4篇 |
2006年 | 3篇 |
2005年 | 4篇 |
2004年 | 5篇 |
2003年 | 1篇 |
2001年 | 2篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1981年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有85条查询结果,搜索用时 0 毫秒
21.
Marie-Lise Benot Cendrine Mony Sara Puijalon Majid Mohammad-Esmaeili Jacques J. M. van Alphen Jan-Bernard Bouzillé Anne Bonis 《Plant Ecology》2009,201(2):621-630
Clonal architecture may enable plants to effectively respond to environmental constraints but its role in plant tolerance
to defoliation remains poorly documented. In several non-clonal species, modifications of plant architecture have been reported
as a mechanism of plant tolerance to defoliation, yet this has been little studied in clonal plants. In a glasshouse experiment,
five rhizomatous and five stoloniferous species of grazed pastures were subjected to three frequencies of defoliation in order
to test two hypotheses. (1) We expected plant clonal response to defoliation to be either a more compact architecture (low
clonal propagation, but high branching), or a more dispersed one (long-distance propagation and low branching). Such plastic
adjustments of clonal architecture were assumed to be involved in tolerance to defoliation i.e. to promote genet performance
in terms of biomass and number of ramets. (2) The response of clonal architecture to defoliation was expected to be dependent
on the species and to be more plastic in stoloniferous than in rhizomatous species. Most genets of each species were tolerant
to defoliation as they survived and developed in every treatment. Architectural modifications in response to defoliation did
not match our predictions. Clonal growth was either maintained or reduced under defoliation. Relative growth rate (RGR) decreased
in eight species, whereas defoliated genets of seven species produced as many ramets as control genets. Biomass allocation
to ramet shoots remained stable for all but one species. In defoliated genets, the number and mean length of connections,
and mean inter-ramet distance were equal to or lower than those in control genets. Four groups of species were distinguished
according to their architectural response to defoliation and did not depend on the type of connections. We hypothesised that
dense clonal architectures with low plasticity may be the most advantageous response in defoliated conditions such as in grazed
pastures.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
22.
Mathilde Bonis Chantal Ecobichon Stephanie Guadagnini Marie‐Christine Prévost Ivo G. Boneca 《Molecular microbiology》2010,78(4):809-819
The molecular basis of the regulation of specific shapes and their role for the bacterial fitness remain largely unknown. We focused in this study on the Gram‐negative and spiral‐shaped Helicobacter pylori. To colonize its unique niche, H. pylori needs to reach quickly the human gastric mucosa, by swimming to and through the mucus layer. For that reason, the specific shape of H. pylori is predicted to be necessary for optimal motility in vivo, and consequently for its colonization ability. Here, we describe the involvement of a PG‐modifying enzyme, HdpA (HP0506), in the mouse colonization ability of this bacterium, by regulating its shape. Indeed, the inactivation of the hp0506 gene led to a stocky and branched phenotype, affecting H. pylori colonization capacity despite a normal motility phenotype in vitro. In contrast, the overexpression of the hp0506 gene induced the transformation of H. pylori from rod to dividing cocci shaped bacteria. Furthermore, we demonstrated by PG analysis and enzymology, that HdpA carried both d ,d ‐carboxypeptidase and d ,d ‐endopeptidase activities. Thus, HdpA is the first enzyme belonging to the M23‐peptidase family able to perform the d ,d ‐carboxypeptidation and regulate cell shape. 相似文献
23.
24.
M. De Angioletti G. Lacerra C. Castaldo R. Cutolo C. de Bonis G. Buonanno C. Carestia 《Human genetics》1992,89(1):37-41
Summary We report here a new human -globin gene rearrangement carrying the two normal, 2 and 1, and two hybrid, 1/2, globin genes in the order 5-2-1/2-1/2-1-3. Both the hybrid genes, subtyped with ApaI and RsaI restriction enzymes, were found to be of the uncommon anti 3.7 type II. The hybrid genes were expressed at the biosynthetic level and their interaction with the -thalassaemia IVS 1 nt 1 GA mutation caused thalassaemia intermedia. We also report a case of an -globin gene rearrangement in the twin of one of the -globin gene carriers; the duplicated gene was of the anti 4.2 type and was associated with the absence of RsaI polymorphism. The singular finding of an -anti 3.7 cluster with two identical rare hybrid genes suggests that the reciprocal unequal recombination causing the -globin gene rearrangements could be of the intra-chromosomal rather than the interchromosomal type. 相似文献
25.
26.
Lorena Ortega Moreno Olga Lamacchia Massimiliano Copetti Lucia Salvemini Concetta De Bonis Salvatore De Cosmo Mauro Cignarelli Vincenzo Trischitta Claudia Menzaghi 《PloS one》2015,10(10)
High serum adiponectin has been increased in several conditions of kidney disease. Only sparse and conflicting results have been reported in patients with type 2 diabetes (T2D), a subgroup of individuals who are at high risk for renal dysfunction. The aim of this study was to fill up this gap of knowledge by investigating such association in a large sample of Italian diabetic patients. The association between serum adiponectin levels and estimated glomerular filtration rate (eGFR by Chronic Kidney Disease-Epidemiology Collaboration CKD-EPI equation) was investigated in 1,243 patients with T2D from two cross-sectional Italian studies: 878 from San Giovanni Rotondo (SGR) and 365 from Foggia (FG). Serum adiponectin was inversely associated with eGFR in SGR [β (standard error, SE) for 1 standard deviation (SD) of adiponectin = -3.26 (0.64)] and in FG [β(SE)=-5.70(1.28)] sample, as well as in the two studies combined [β(SE)=-3.99(0.59)];(p<0.0001 for all). In this combined analysis, the association was still significant after adjusting for sex, smoking habits, body mass index (BMI), waist circumference, diabetes duration, glycated hemoglobin (HbA1c), albumin creatinine ratio (ACR) and anti-hyperglycemic, anti-hypertensive and anti-dyslipidemic treatments [β (SE)= -2.19 (0.59), p = 0.0001]. A stronger association between each SD adiponectin increment and low eGFR was observed among patients with micro-/macro-albuminuria, as compared to those with normo-albuminuria [adjusted β(SE)=-4.42(1.16) ml/min/1.73m2 vs. -1.50 (0.67) ml/min/1.73m2, respectively; p for adiponectin-by-albuminuric status = 0.022]. For each adiponectin SD increment, the odds of having eGFR < 60 ml/min/1.73m2 increased by 41% (odds ratio, OR = 1.41; 95% confidence interval, CI 1.21–1.64) in SGR sample, 53% (OR = 1.53; 95% CI 1.21–1.94) in FG sample, and 44% (OR = 1.44; 95%CI 1.27–1.64) in the two studies considered together (p<0.0001 for all). In the combined sample, further adjustment for the above mentioned covariates did not change the observed association (OR = 1.36; 95%CI 1.16–1.60; p<0.0001). Our study, so far the largest addressing the relationship between serum adiponectin and GFR in T2D, strongly suggests that the paradoxical inverse association, previously reported in different clinical sets, is also observed in diabetic patients. Further studies are needed to unravel the biology underlying this counterintuitive relationship. 相似文献
27.
Louis de Bonis Stphane Peign Andossa Likius Hassane Taïsso Mackaye Patrick Vignaud Michel Brunet 《Comptes Rendus Palevol》2005,4(8):221
A new species of Hyaenidae, Hyaenictitherium minimum, is described in the carnivore fauna of the Late Miocene layers of Toros-Menalla (Chad). Its size is similar to that of a jackal and it had probably a similar ecological niche. It is found in several fossil-bearing localities of this area. The genus Hyaenictitherium is known from the early Late Miocene in Eurasia from China to Spain; the Chadian material is, perhaps with some specimens from Sahabi and Lothagam, the earliest occurrence of the genus in Africa. It results certainly from Eurasian migration, which will have to be taken into account for the analysis of the bulk of the fauna. To cite this article: L. de Bonis et al., C. R. Palevol 4 (2005). 相似文献
28.
29.
Louis de Bonis Stéphane Peigné Hassane Taisso Mackaye Andossa Likius Patrick Vignaud Michel Brunet 《Comptes Rendus Palevol》2010,9(5):221-227
The Toros Menalla Late Miocene Formation (7 Ma), Djurab desert, Chad, has yielded a large number of vertebrate remains, and among them around twenty taxa of carnivores. Recent collections allow us to describe two sabre-toothed felids assigned to the genera Lokotunjailurus and cf. Megantereon. The former does exist in the Nawata Formation, Lothagam, northern Kenya with a slightly derived species and the TM specimens are considered as belonging to a new species. The latter cannot be identified to the species level, but it could be one of the earliest specimens of Megantereon known in the world and it would reinforce the hypothesis of an Old World origin for this taxon. Both allow us to put forward some biogeographical conclusions. 相似文献
30.
The presence of a halophytic and sub-halophytic flora in grasslands reclaimed from the sea several centuries ago on the west Atlantic coast in France appears very unusual and the reasons for its survival are still uncertain. Our objective is to document its distribution pattern and to investigate whether its persistence is related to abiotic conditions and/or management practices. Vegetation surveys were carried out in seven different sites with 26 relevés on grazed sites (15 on slopes and 10 on flats) and 11 on mown sites (six on slopes and five on flats).This flora shows some important similarity with the vegetation of recent polders and can be classified into groups of species differing by their degree of salt tolerance but also their response to management mode. It was found that halophytes are only present on very saline soils, in a situation where the level of competition with more competitive species is reduced. The sub-halophytes also required low competition on lower soil salinity. In old polders, these two groups only occurred on grazed slopes and declined or even disappeared in the absence of grazing. In exclosures, the community became strongly dominated by competitive species and the soil salinity decreased on the slopes. The maintenance of sub-halophytes in old polders seems to be mainly conditioned by competition limitation whereas halophytes showed also a strong dependency to soil salt level, two requirements, which are met on continuously grazed slopes. Grazing maintains inter-specific competition at a low level while trampling increases soil compaction. Soil compaction modifies water and salt circulation, which could explain the high level of soil conductivity observed on grazed slopes. 相似文献