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91.
L F Sukhodub V D Chivanov L I Grebenik P V Bondarenko R A Zubarev A N Knysh 《Ukrainski? biokhimicheski? zhurnal》1992,64(1):41-49
Study of interaction of the antitumor alkylating drug triethylenethiophosphoramide (thioTEPA) with nucleotides (dGMP and dCMP) suggests highly perspective employment of 252-Cf fission fragment induced desorption mass spectrometry (252-Cf PDMS) in biochemical pharmacology. Using the 252-Cf PDMS the molecular masses of the unstable, unvolatile, high-molecular substances of biological origin and the chemical adducts or complexes with drugs can be used to establish some structural-functional parameters of the above mentioned biomolecules and their derivatives in microvolumes of the incubation medium. The resulting data may be used for modelling chemotherapeutic processes of "drug-biomolecule-target" type. Using 252-Cf PDMS the complexes (dGMP (thioTEPA) n), n = 1, 2, 3 and (dCMP (thioTEPA) n), n = 1, were obtained. Some quantitative parameters and stability of these complexes were studied. Binding of dGMP with drug in the presence of dCMP was shown preferential. The data are compatible with the predictions concerning the mechanism of the antitumor property of the thioTEPA which can be manifested in the impairment structure of DNA of the malignant cells. 相似文献
92.
S.?A.?Bondarenko E.?A.?Ianutsevich N.?A.?Sinitsyna M.?L.?Georgieva E.?N.?Bilanenko B.?M.?TereshinaEmail author 《Microbiology》2018,87(1):21-32
Comparative composition of lipids and cytosol soluble carbohydrates at different ambient pH values was studied for two obligately alkaliphilic fungi (Sodiomyces magadii and S. alkalinus) and for two alkalitolerant ones (Acrostalagmus luteoalbus and Chordomyces antarcticus). The differences and common patterns were revealed in responses to pH stress for the fungi with different types of adaptation to ambient pH. While trehalose was one of the major cytosol carbohydrates in alkaliphilic fungi under optimal growth conditions (pH 10.2), pH decrease to 7.0 resulted in doubling its content. In alkalitolerant fungi trehalose was a minor component and its level did not change significantly at different pH. In alkalitolerant fungi, arabitol and mannitol were the major carbohydrate components, with their highest ratio observed under alkaline conditions and the lowest one, under neutral and acidic conditions. In alkaliphiles, significant levels of arabitol were revealed only under alkaline conditions, which indicated importance of trehalose and arabitol for alkaliphily. Decreased pH resulted in the doubling of the proportion of phosphatidic acids among the membrane lipids, which was accompanied by a decrease in the fractions of phosphatidylcholines and sterols. Alkalitolerant fungi also exhibited a decrease in sterol level at decreased pH, but against the background of increased proportion of one of phospholipids. Decreased unsaturation degree in the fatty acids of the major phospholipids was a common response to decreased ambient pH. 相似文献
93.
L. A. Bondarenko 《Neurophysiology》1997,29(3):168-188
In this review, the information available from the literature and the data obtained by the author about the epiphysis (or
the pineal gland), an important neuroendocrine organ, and about its main hormone, melatonin, are summarized. The history of
studying the epiphysis and the evolutionary aspects of its activity, anatomy, and physiology are discussed. The results of
electrophysiological studies are described, and biochemical aspects of the epiphysis activity are analyzed. The pathways through
which photoinformation enters the pineal gland, and external factors regulating its functioning are described in detail. The
data on the physiological effects produced by epiphyseal neurohormones (melatonin is the best studied) and their role in formation
of different types of behavior are emphasized. 相似文献
94.
95.
L A Bondarenko 《Ontogenez》1991,22(1):57-62
We have studied metabolic pathways of serotonin in epiphysis of Wistar male rats at the age of 1; 1,5; 2; 3; 6; 12; 24 and 36 months. Epiphysis retains its functional activity throughout the life, however, serotonin metabolism in epiphysis undergoes marked changes. The main regulatory principle is the switch of serotonin metabolic pathways in the pineal gland. Most distinct changes between hydroxy- and methoxyindols in epiphysis have been observed during the periods of age-associated hormonal rearrangements like sexual maturation or involution of the gonad function at the old age. 相似文献
96.
A A Lentsner L A Levkov Kh P Lentsner V M Bondarenko 《Antibiotiki i khimioterapii͡a》1989,34(6):430-432
Reciprocal effect of 4 strains of Klebsiella pneumoniae and 6 Lactobacillus strains on their cytadhesion in mixed populations was studied on a model of formalinized human erythrocytes. The Lactobacillus strains included 2 strains of Lactobacillus casei subsp. casei, 2 strains of L. plantarum and 2 strains of L. fermentum. It was shown that adhesion of both the Klebsiella and the Lactobacillus strains changed under their reciprocal effect. The changes were characterized by the strain differences and depended on the quantitative ratio of the microorganisms. 相似文献
97.
K. A. Razumova V. V. Alikaev I. S. Bondarenko A. A. Borschegovskii V. A. Vershkov A. V. Gorshkov Yu. V. Gott Yu. N. Dnestrovskij V. V. Dreval M. M. Dremin L. G. Eliseev G. S. Kirnev A. Ya. Kislov I. V. Klimanov A. S. Kozachok A. D. Komarov V. A. Krupin L. I. Krupnik S. V. Krylov S. E. Lysenko A. A. Medvedev A. V. Melnikov T. B. Myalton G. E. Notkin A. Yu. Novikov Yu. D. Pavlov D. P. Petrov V. I. Poznyak I. N. Roy P. V. Savrukhin V. V. Sannikov S. V. Soldatov A. V. Sushkov V. M. Trukhin S. M. Khrebtov V. V. Chistyakov D. A. Shelukhin 《Plasma Physics Reports》2001,27(4):273-277
Abstract-the formation of transport barriers under electron cyclotron resonance heating and current drive in the t-10 tokamak is studied. in regimes with off-axis co-eccd and q L <4 at the limiter, a spontaneous transition to improved confinement accompanied by the formation of two electron transport barriers is observed. the improvement resembles an L-H transition. It manifests itself as density growth, a decrease in the Dα emission intensity, and an increase in the central electron and ion temperatures. Two deep wells on the potential profile (the first one at r/a L ≈0.6, where a L is the limiter radius, and the second one near the edge) arise during the transition. the internal barrier is formed when dq/dr~0 with q≈1 in the barrier region. 相似文献
98.
S. M. Kal’noi I. V. Zharnikova A. A. Zaitsev A. I. Bondarenko I. Yu. Borzdova V. V. Ostapovich A. A. Kurilova 《Applied Biochemistry and Microbiology》2010,46(4):449-457
The possibility of detecting antigens of plague, tularemia, and brucellosis microbes with magnetic latex (ML)-based test systems
has been demonstrated. MLs were prepared from latexes (polyacroleine microspheres, 1.2–1.8 ± 0.1 μm) by exposing the particles
to a 25–35%-solution of ferrous sulfate for 0.5 h and then to a 15–25%-aqueous solution of ammonia for 0.5 h in a 100°C water
bath and dehydrating after each operation. The possibility of preparing magnetic latex immunosorbents (MLIS) by ligand immobilization
on ML and using them in magnetic latex ELISA (ML-ELISA) for the detection of microbial antigens was demonstrated. The detection
limit in ML-ELISA equaled 102–103 microbial cells in 1 ml (cells/ml). Relative experimental error was not higher than 8%. 相似文献
99.
100.
A V Gorelov E M Gorskaia V G Zhukhovitski? V M Bondarenko 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1990,(7):3-6
The adhesive activity of C. jejuni isolated from feces of children with Campylobacter infection was studied with the use of a newly developed model. 47 clinical isolates were analyzed; of these, 91% were found to be enteroadhesive to a variable degree. As the result of in vitro studies, Campylobacter were found to have much greater tropism to colonic cells and epithelial cells of Peyer's patches in comparison with the epithelial cells of the small intestine. The correlation between the degree of adhesive activity and the severity of the course of Campylobacter infection in children. 相似文献