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排序方式: 共有217条查询结果,搜索用时 946 毫秒
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Cateni F Doljak B Zacchigna M Anderluh M Piltaver A Scialino G Banfi E 《Bioorganic & medicinal chemistry letters》2007,17(22):6330-6334
From the fungus Stereum hirsutum have been isolated and identified two new epidioxysterols 1, 4, together with two known ones 2 and 3. Their structures were elucidated on the basis of spectroscopic analysis and chemical reactions. Epidioxysterols 1-4 have been shown to possess a significant activity against Mycobacterium tuberculosis. 相似文献
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Aleksandar Mikić Petr Smýkal Gregory Kenicer Margarita Vishnyakova Nune Sarukhanyan Janna A. Akopian Armen Vanyan Ivan Gabrielyan Iva Smýkalová Ekaterina Sherbakova Lana Zorić Jovanka Atlagić Tijana Zeremski-Škorić Branko Ćupina Đorđe Krstić Igor Jajić Svetlana Antanasović Vuk Đorđević Vojislav Mihailović Alexandr Ivanov Sergio Ochatt Cengiz Toker Bojan Zlatković Mike Ambrose 《Planta》2014,240(5):1147-1147
75.
Bojan Zagrovic 《Genome biology》2014,15(1):102
Combining the prediction of interactions between mRNAs and RNA-binding proteins with experimental expression profiles uncovers novel regulatory paradigms concerning proliferation and differentiation processes.See related research, http://genomebiology.com/2014/15/1/R13 相似文献
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Helicobacter pylori resistance rates to antibiotics vary in different countries and even in different regions of the same country. Choice of treatment is strongly dependent on antibiotic resistance rates. In some countries, triple therapy with a proton-pump inhibitor, amoxicillin, and clarithromycin is still the best option, but eradication results fall short of what would be desired (90-95%) in countries with clarithromycin resistance >20%, bismuth-containing quadruple therapy, or nonbismuth sequential or concomitant therapies may then be the preferred option. Newer antibiotic regimens are awaited. Vaccination would be the best option, especially for developing countries, but little progress has been made in designing a vaccine. 相似文献
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Pavle Goldstein Jurica Zucko Du?ica Vujaklija Anita Kri?ko Daslav Hranueli Paul F Long Catherine Etchebest Bojan Basrak John Cullum 《BMC bioinformatics》2009,10(1):335
Background
The number of protein family members defined by DNA sequencing is usually much larger than those characterised experimentally. This paper describes a method to divide protein families into subtypes purely on sequence criteria. Comparison with experimental data allows an independent test of the quality of the clustering. 相似文献79.
Microcystins Induce Morphological and Physiological Changes in Selected Representative Phytoplanktons 总被引:1,自引:0,他引:1
Dissolved microcystins (MCs) are regularly present in water dominated by microcystin-producing, bloom-forming cyanobacteria. In vitro experiments with environmentally feasible concentrations (5 × 10−7 M) of the three most common microcystins, MC-LR, MC-RR, and MC-YR, revealed that they influence the metabolism of different representative phytoplanktons. At light intensities that are close to the cyanobacterial bloom environment (50 μmol m−2 s−1), they produce morphological and physiological changes in both microcystin-producing and -nonproducing Microcystis aeruginosa strains and also have similar effects on the green alga Scenedesmus quadricauda that is frequently present in cyanobacterial blooms. All three microcystin variants tested induce cell aggregation, increase in cell volume, and overproduction of photosynthetic pigments. All three effects appear to be related to each other but are not necessarily caused by the same mechanism. The biological activity of microcystins toward the light-harvesting complex of photobionts can be interpreted as a signal announcing the worsening of light conditions due to the massive proliferation of cyanobacteria. Although the function of microcystins is still unknown, it is evident that they have numerous effects on phytoplankton in nature. These effects depend on the individual organism as well as on the various intracellular and extracellular signaling pathways. The fact that dissolved microcystins also influence the physiology of microcystin-producing cyanobacteria leads us to the conclusion that the role of microcystins in the producing cells differs from the role in the water environment. 相似文献
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