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121.
保护声学(Conservation acoustics)是基于物种及生态环境保护需求而发展出的声学分支, 重点研究与保护相关的声学理论、技术及应用, 涉及保护生物学、生物声学和生态声学等关联学科。研究小型鲸类发声和受声及栖息地声学特征, 有助于了解种群生存状况, 制订和实施基于声学的保护对策, 促进物种和生态环境保护。我国小型鲸类保护声学源起于20世纪80年代白鱀豚(
122.
Sipeng Wu Yiqi Cai Lixiao Zhang Xiang Li Xu Liu Guangkeng Zhou Hongdi Luo Renjian Li Yujia Huo Zhirong Zhang Siyi Chen Jinliang Huang Jiahao Shi Shanwei Ding Zhe Sun Zizhuo Zhou Pengcheng Wang Geng Wang 《蛋白质与细胞》2025,16(1):28-48
One of the basic questions in the aging field is whether there is a fundamental difference between the aging of lower invertebrates and mammals. A major difference between the lower invertebrates and mammals is the abundancy of noncoding RNAs, most of which are not conserved. We have previously identified a noncoding RNA Terc-53 that is derived from the RNA component of telomerase Terc. To study its physiological functions, we generated two transgenic mouse models overexpressing the RNA in wild-type and early-aging Terc-/- backgrounds. Terc-53 mice showed age-related cognition decline and shortened life span, even though no developmental defects or physiological abnormality at an early age was observed, indicating its involvement in normal aging of mammals. Subsequent mechanistic study identified hyaluronan-mediated motility receptor (Hmmr) as the main effector of Terc-53. Terc-53 mediates the degradation of Hmmr, leading to an increase of inflammation in the affected tissues, accelerating organismal aging. adeno-associated virus delivered supplementation of Hmmr in the hippocampus reversed the cognition decline in Terc-53 transgenic mice. Neither Terc-53 nor Hmmr has homologs in C. elegans. Neither do arthropods express hyaluronan. These findings demonstrate the complexity of aging in mammals and open new paths for exploring noncoding RNA and Hmmr as means of treating age-related physical debilities and improving healthspan. 相似文献
123.
Jiayu Yang;Yuting Lu;Ying Dong;Jinguo Ding;Wenzhu Li;Yingting Shi;Xinyuan Xie;Jianyang Pan;Haibin Qu; 《Phytochemical analysis : PCA》2024,35(6):1294-1308
Herbal preparations are extensively utilised for the treatment of diseases in Asian countries. However, the variations in origin, climate, and production processes can lead to inconsistencies in the quality of herbal preparations. Existing quality control methods only target a few components in the finished product but ignore the control in the pharmaceutical process. Therefore, this study intends to develop a comprehensive component analysis method for intermediates in the pharmaceutical process to reveal the change patterns of substances and deepen the process understanding. 相似文献
124.
125.
Wenyu Wang;Yaqun Li;Wei Wang;Keren Ding;Kun Zhang;Yulan Zhang;Kai Liu;Jingyuan Li;Dongwei Li;Ruiyuan Lian;Daijia Li;Jian Gu;Jie Li; 《Global Change Biology》2024,30(12):e70007
Nitrogen (N) transformation inhibitors have been widely recognized as a promising strategy to enhance crop productivity and mitigate N losses. However, the effectiveness of individual or combined inhibitors can vary significantly across different agroecosystems. Using meta-analysis and cost–benefit analysis (CBA), we synthesized findings from 41 peer-reviewed studies (285 observations) globally to evaluate the efficacy of urease inhibitors (UIs), nitrification inhibitors (NIs), and combined inhibitors (UINIs). We assessed their influence on soil inorganic N transformations, greenhouse gas emissions, and crop productivity across diverse climates, soil types, cropping systems, and fertilization practices. Our results indicated that combined UINIs were the most efficient, increasing crop yields by 5% and mitigating gaseous emissions by 51% compared to UIs or NIs alone. UINIs achieved these benefits by enhancing crop ammonium (NH4+) availability through regulating urea hydrolysis and prolonging NH4+ retention by suppressing nitrification in the soil. The CBA revealed that the overall economic benefits of UINIs application outweighed the costs, resulting in a net monetary benefit of $23.36 ha−1, equivalent to a 6.4% increase in revenue. Both meta-regression and random forest analyses suggested that UINIs performance was strongly influenced by factors such as N application rate, organic matter content, and soil pH. Notably, more substantial responses were observed in fine-textured soils and/or crops exposed to high N fertilization rates. Acidic soils (pH < 6.5) exhibited the largest effect sizes, with increased crop productivity and reduced NH3 volatilization due to specific inhibitory interactions. In conclusion, these findings highlight UINIs beneficial impacts on crop productivity and environmental conservation, achieving a “win-win” scenario by addressing various N-loss challenges while enhancing economic outcomes. Further exploration and optimization of the interaction between climate, soil, plant, and management systems and the use of appropriate inhibitors are crucial for maximizing their positive impact on global climate and reaping corresponding economic benefits. 相似文献
126.
Bo Ma;Lei Xiu;Lili Ding; 《FASEB BioAdvances》2024,6(4):105-117
N6-methyladenosine (m6A) modification plays a crucial role in cancer progression. However, the role of m6A modification-mediated autophagy underlying non-small cell lung cancer (NSCLC) gefitinib resistance remains unknown. Here, we discovered that m6A methyltransferase KIAA1429 was highly expressed in NSCLC gefitinib-resistant cells (PC9-GR) as well as tissues, and KIAA1429 high expression was associated with poor survival. In addition, silent KIAA1429 repressed gefitinib resistance in NSCLC and reduced tumor growth in vivo. Mechanistically, KIAA1429 stabilized WTAP, a significant player in autophagy, by binding to the 3′ untranslated regions (3′-UTR) of WTAP. In a word, our findings indicated that KIAA1429 could elevate NSCLC gefitinib resistance, which may provide a promising targeted therapy for NSCLC patients. 相似文献
127.
Yongxin Nie;Hui Wang;Guan Zhang;Haiping Ding;Beibei Han;Lei Liu;Jian Shi;Jiyuan Du;Xiaohu Li;Xinzheng Li;Yajie Zhao;Xiaocong Zhang;Changlin Liu;Jianfeng Weng;Xinhai Li;Xiansheng Zhang;Xiangyu Zhao;Guangtang Pan;David Jackson;Qin-Bao Li;Philip S. Stinard;Jennifer Arp;Martin M. Sachs;Steven Moose;Charles T. Hunter;Qingyu Wu;Zhiming Zhang; 《The Plant journal : for cell and molecular biology》2024,118(2):457-468
Carotenoids perform a broad range of important functions in humans; therefore, carotenoid biofortification of maize (Zea mays L.), one of the most highly produced cereal crops worldwide, would have a global impact on human health. PLASTID TERMINAL OXIDASE (PTOX) genes play an important role in carotenoid metabolism; however, the possible function of PTOX in carotenoid biosynthesis in maize has not yet been explored. In this study, we characterized the maize PTOX locus by forward- and reverse-genetic analyses. While most higher plant species possess a single copy of the PTOX gene, maize carries two tandemly duplicated copies. Characterization of mutants revealed that disruption of either copy resulted in a carotenoid-deficient phenotype. We identified mutations in the PTOX genes as being causal of the classic maize mutant, albescent1. Remarkably, overexpression of ZmPTOX1 significantly improved the content of carotenoids, especially β-carotene (provitamin A), which was increased by ~threefold, in maize kernels. Overall, our study shows that maize PTOX locus plays an important role in carotenoid biosynthesis in maize kernels and suggests that fine-tuning the expression of this gene could improve the nutritional value of cereal grains. 相似文献
128.
Lulu Yan;Shuxia Ding;Yan He;Bin Fu;Changshui Chen;Haibo Li; 《Molecular Genetics & Genomic Medicine》2024,12(8):e2507
Mucopolysaccharidosis type I (MPS-I) is a rare autosomal recessive genetic lysosomal storage disorder that is caused by pathogenic variants of the α-L-iduronidase (IDUA) gene. This study aimed to identify the genetic causes of MPS-I in a Chinese patient and construct a minigene of IDUA to analyze its variants upon splicing. 相似文献
129.
Jie Hao Jiani Cao Lei Wang Aijin Ma Si Chen Jinfeng Ding Liu Wang Boqiang Fu Yu Zhang Xuetao Pei Peng Xiang Qiyuan Li Yong Zhang Jiaxi Zhou Shijun Hu Junying Yu Jun Wei Huanxin Zhu Glyn Stacey Tongbiao Zhao Qi Zhou 《Cell proliferation》2020,53(12)
‘Requirements for Human Embryonic Stem Cells’ is the first set of guidelines on human embryonic stem cells in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements and transportation requirements for human embryonic stem cells, which is applicable to the quality control for human embryonic stem cells. It was originally released by the China Society for Cell Biology on 26 February 2019 and was further revised on 30 April 2020. We hope that publication of these guidelines will promote institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of human embryonic stem cells for applications. 相似文献
130.