Ein neues germacran-8.12-olid und neue diterpene aus Polymnia canadensis

The aerial parts of P. canadensis afforded a new germacran-8,12-olide and several diterpenic acids. The stereochemistry of the lactone could be established only by careful ¹H NMR investigations of the corresponding pyrazolines formed by addition of diazomethane, while the natural compound and its acetate only show very uncharacteristic NMR spectra. The diterpenes all belong to the rare isokaurene type. The chemotaxonomic aspects are discussed briefly.     

Neue diterpene und neue dihydrochalkon-derivate sowie weitere inhaltsstoffe aus Helichrysum-arten

The investigation of 25 further Helichrysum species afforded in addition to known compounds a new diterpene, an oxo-geranyllinalol, a second one, most probably a cembrene derivative, and three dihydrochalkone derivatives. The distribution of the constituents in South African Helichrysum species is discussed briefly.     

Sesquiterpene lactones of Podanthus mitiqui

Ovatifolin and two new sesquiterpene lactones, deacetylovatifolin and arturin (1β-hydroxy-8β-angeloyloxy-eudesmane-4(15),11(13)-diene-6α,12-olide, have been isolated from stems and leaves of Podanthus mitiqui. Two of these compounds showed cytotoxic activity.     

Seven furanoeremophilanes from three Senecio species

The investigation of two further Senecio species and the re-investigation of S. inaequidens afforded, in addition to known compounds, seven new furanoeremophilane derivatives. Six of these are closely related to cacalol, a sesquiterpene type which predominates in the species investigated.     

Sesquiterpene lactones from Eremanthus species

The investigation of three Eremanthus species afforded, in addition to known compounds, several new sesquiterpenelactones, a cumambrin B isobutyrate, four lactones related to the eremantholides, two to zexbrevin and one to goyazensolide. Furthermore, a new coniferyl alcohol derivative was isolated. The overall picture of the genus is very uniform. The occurrence of eremanthine and germacranolides with a furanone ring seems to be especially typical.     

Neue,abgewandelte pseudoguajanolide aus Psilostrophe villosa

Investigation of the North American species Psilostrophe villosa afforded, in addition to known compounds, five new sesquiterpene lactones, which all turn out to be modified pseudoguaianolides, most of them closely related to hymenolide. However, one of the lactones is a new type of nor-pseudoguaianolide. Furthermore a new monoacetylated borneol-β-D-glucoside is present. The chemotaxonomic situation is discussed briefly.