全文获取类型
收费全文 | 220篇 |
免费 | 14篇 |
专业分类
234篇 |
出版年
2019年 | 8篇 |
2018年 | 5篇 |
2016年 | 4篇 |
2015年 | 2篇 |
2014年 | 13篇 |
2013年 | 13篇 |
2012年 | 17篇 |
2011年 | 9篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 9篇 |
2007年 | 8篇 |
2006年 | 13篇 |
2005年 | 12篇 |
2004年 | 8篇 |
2003年 | 8篇 |
2002年 | 12篇 |
2001年 | 4篇 |
1999年 | 3篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1994年 | 4篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1985年 | 5篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1972年 | 4篇 |
1971年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1963年 | 3篇 |
1961年 | 1篇 |
1960年 | 1篇 |
1959年 | 2篇 |
1958年 | 1篇 |
1957年 | 1篇 |
1907年 | 1篇 |
排序方式: 共有234条查询结果,搜索用时 15 毫秒
81.
Kexue Li Lawrence R. McGee Ben Fisher Athena Sudom Jinsong Liu Steven M. Rubenstein Mohmed K. Anwer Timothy D. Cushing Youngsook Shin Merrill Ayres Fei Lee John Eksterowicz Paul Faulder Bohdan Waszkowycz Olga Plotnikova Ellyn Farrelly Shou-Hua Xiao Guoqing Chen Zhulun Wang 《Bioorganic & medicinal chemistry letters》2013,23(5):1238-1244
The discovery, structure-based design, synthesis, and optimization of NIK inhibitors are described. Our work began with an HTS hit, imidazopyridinyl pyrimidinamine 1. We utilized homology modeling and conformational analysis to optimize the indole scaffold leading to the discovery of novel and potent conformationally constrained inhibitors such as compounds 25 and 28. Compounds 25 and 31 were co-crystallized with NIK kinase domain to provide structural insights. 相似文献
82.
Streptomyces ghanaensis pleiotropic regulatory gene wblA(gh) influences morphogenesis and moenomycin production 总被引:1,自引:0,他引:1
The wblA
gh
gene, encoding a homologue of the WhiB-family of proteins, was identified in the sequenced genome of moenomycin producer
Streptomyces ghanaensis. Deletion of the gene blocked aerial mycelium sporulation and caused a 230% increase in moenomycins production. S. ghanaensis overexpressing SSFG-01620: a homologue of extracellular protease inhibitor SCO0762, whose expression in Streptomyces coelicolor is down-regulated by wblA: showed deficiencies in sporulation similar to that of wblA
gh
knockout strain. The wblA
gh
gene of S. ghanaensis appears to play a negative role in the control of moenomycin biosynthesis and is essential for sporulation. 相似文献
83.
84.
Blind upper extremity amputees have historically been excluded from consideration for hand allotransplantation. Although no formal position statement regarding their exclusion has been published to date, functional, rehabilitative, and ethical concerns related to blind amputee candidacy for hand transplantation may be inferred. The authors provide a summary of these reservations and a counterargument to their assumptions, drawing on outcomes measures reported for hand transplantations completed to date. The authors therefore provide a rationale for the inclusion of blind amputees in hand transplantation protocols in the future. 相似文献
85.
86.
87.
Sequence analysis of 2 kb BamHI-SmaI fragment of landomycin E (LaE) gene cluster in Streptomyces globisporus 1912 revealed one complete ORF marked as lndJ. Analysis of putative lndJ aminoacid sequence allowed us to suppose that it is proton-dependent antiporter which could be involved in resistance to
LaE in the producing strain. Although disruption of lndJ had no significant influence on LaE production and resistance, its overexpression in wild type and LaE overproducing strains
led to qualitative changes in landomycins biosynthesis and increased resistance to LaE. These data support the hypothesis
about involvement of lndJ gene in landomycins export.
The text was submitted by the authors in English. 相似文献
88.
Facially disfigured blind patients have historically been considered for face transplantation with skepticism. Although no formal position paper regarding their exclusion has been published to date, functional, social, rehabilitative, and ethical concerns related to blind patients' candidacy for face transplantation may be inferred. The authors provide a summary of these reservations and a counterargument to their assumptions, drawing on outcomes measures reported for face transplant procedures performed to date, and their own institutional experience in performing face transplants on blind patients. The authors therefore provide a rationale for the inclusion of facially disfigured blind patients in face transplantation protocols in the future. 相似文献
89.
90.
Tetiana Gren Bohdan Ostash Volodymyr Babiy Ihor Rokytskyy Victor Fedorenko 《Folia microbiologica》2018,63(2):197-201
Streptomyces coelicolor genome carries two apparently paralogous genes, SCO4164 and SCO5854, that encode putative thiosulfate sulfurtransferases (rhodaneses). These genes (and their presumed translation products) are highly conserved and widely distributed across actinobacterial genomes. The SCO4164 knockout strain was unable to grow on minimal media with either sulfate or sulfite as the sole sulfur source. The SCO5854 mutant had no growth defects in the presence of various sulfur sources; however, it produced significantly less amounts of actinorhodin. Furthermore, we discuss possible links between basic interconversions of inorganic sulfur species and secondary metabolism in S. coelicolor. 相似文献