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排序方式: 共有211条查询结果,搜索用时 62 毫秒
71.
Menkiszak J Brzosko M Górski B Fliciński J Jakubowska A Zebiełowicz D Gronwald J Huzarski T Byrski T Teresiński L Chosia M Rzepka-Górska I Lubiński J 《Journal of applied genetics》2004,45(2):255-263
The study aimed to determine whether hereditary ovarian cancers that are not caused by BRCA1/BRCA2 constitutional mutations are associated with a predisposition to cystadenoma. The study consisted of two parts. Part one concerned the incidence of ovarian cystadenoma in females from families with hereditary ovarian cancer unassociated with BRCA1 mutations. The study group included 62 female patients from 29 families, without any previously diagnosed malignancy, with no proven constitutional mutation of the BRCA1 gene. The first control group was composed of 62 female patients from 53 families, without any previously diagnosed malignancy, with an identified constitutional mutation of the BRCA1 gene. The second control group comprised 124 female patients for whom the only reason for the examination was a prophylactic check-up. All studied women were subjected to intravaginal ultra- sonographic investigations. In 8 patients with benign and/or borderline ovarian cystadenoma, a complete sequencing of coding fragments of the BRCA2 gene from the peripheral blood DNA was performed. Part two of this study concerned the incidence and pattern of malignant tumors in the families of female patients with ovarian cystadenoma. The final study group included 117 patients who had 726 I0 relatives (359 females and 367 males). We concluded that cystadenoma is likely to be a characteristic feature of the subgroup of families with hereditary ovarian cancers unassociated with BRCA1/BRCA2 constitutional mutations. 相似文献
72.
Stefańska J Młynarczyk G Młynarczyk A Starościak B Łuczak M 《Medycyna do?wiadczalna i mikrobiologia》2002,54(3):183-189
The 31 strains of Staphylococcus aureus were examined for the presence of smr and qacA determinants. The smr gene was found in 15 strains. Fourteen of them were MRSA resistant to quaternary ammonium compounds, ethidium bromide, and acriflavine. One was MSSA strain resistant to ethidium bromide and acriflavine. The qacA gene was found in two MRSA strains resistant to quaternary ammonium compounds, ethidium bromide, chlorhexidine and acriflavine. One of these two strains possessed both smr and qacA genes. 相似文献
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Kexue Li Lawrence R. McGee Ben Fisher Athena Sudom Jinsong Liu Steven M. Rubenstein Mohmed K. Anwer Timothy D. Cushing Youngsook Shin Merrill Ayres Fei Lee John Eksterowicz Paul Faulder Bohdan Waszkowycz Olga Plotnikova Ellyn Farrelly Shou-Hua Xiao Guoqing Chen Zhulun Wang 《Bioorganic & medicinal chemistry letters》2013,23(5):1238-1244
The discovery, structure-based design, synthesis, and optimization of NIK inhibitors are described. Our work began with an HTS hit, imidazopyridinyl pyrimidinamine 1. We utilized homology modeling and conformational analysis to optimize the indole scaffold leading to the discovery of novel and potent conformationally constrained inhibitors such as compounds 25 and 28. Compounds 25 and 31 were co-crystallized with NIK kinase domain to provide structural insights. 相似文献
75.
Streptomyces ghanaensis pleiotropic regulatory gene wblA(gh) influences morphogenesis and moenomycin production 总被引:1,自引:0,他引:1
The wblA
gh
gene, encoding a homologue of the WhiB-family of proteins, was identified in the sequenced genome of moenomycin producer
Streptomyces ghanaensis. Deletion of the gene blocked aerial mycelium sporulation and caused a 230% increase in moenomycins production. S. ghanaensis overexpressing SSFG-01620: a homologue of extracellular protease inhibitor SCO0762, whose expression in Streptomyces coelicolor is down-regulated by wblA: showed deficiencies in sporulation similar to that of wblA
gh
knockout strain. The wblA
gh
gene of S. ghanaensis appears to play a negative role in the control of moenomycin biosynthesis and is essential for sporulation. 相似文献
76.
77.
Blind upper extremity amputees have historically been excluded from consideration for hand allotransplantation. Although no formal position statement regarding their exclusion has been published to date, functional, rehabilitative, and ethical concerns related to blind amputee candidacy for hand transplantation may be inferred. The authors provide a summary of these reservations and a counterargument to their assumptions, drawing on outcomes measures reported for hand transplantations completed to date. The authors therefore provide a rationale for the inclusion of blind amputees in hand transplantation protocols in the future. 相似文献
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