全文获取类型
收费全文 | 2281篇 |
免费 | 206篇 |
国内免费 | 2篇 |
出版年
2023年 | 6篇 |
2022年 | 13篇 |
2021年 | 30篇 |
2020年 | 24篇 |
2019年 | 17篇 |
2018年 | 39篇 |
2017年 | 34篇 |
2016年 | 60篇 |
2015年 | 109篇 |
2014年 | 128篇 |
2013年 | 130篇 |
2012年 | 175篇 |
2011年 | 154篇 |
2010年 | 104篇 |
2009年 | 102篇 |
2008年 | 142篇 |
2007年 | 150篇 |
2006年 | 172篇 |
2005年 | 144篇 |
2004年 | 114篇 |
2003年 | 123篇 |
2002年 | 136篇 |
2001年 | 23篇 |
2000年 | 18篇 |
1999年 | 22篇 |
1998年 | 33篇 |
1997年 | 20篇 |
1996年 | 29篇 |
1995年 | 23篇 |
1994年 | 31篇 |
1993年 | 18篇 |
1992年 | 25篇 |
1991年 | 14篇 |
1990年 | 11篇 |
1989年 | 17篇 |
1988年 | 12篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 13篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 7篇 |
1978年 | 4篇 |
1976年 | 9篇 |
1975年 | 3篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1965年 | 2篇 |
1951年 | 2篇 |
排序方式: 共有2489条查询结果,搜索用时 0 毫秒
161.
Tyagarajan S Chakravarty PK Zhou B Taylor B Eid R Fisher MH Parsons WH Wyvratt MJ Lyons KA Klatt T Li X Kumar S Williams B Felix J Priest BT Brochu RM Warren V Smith M Garcia M Kaczorowski GJ Martin WJ Abbadie C McGowan E Jochnowitz N Weber A Duffy JL 《Bioorganic & medicinal chemistry letters》2010,20(24):7479-7482
A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain. 相似文献
162.
Christina Liedert Jörg Bernhardt Dirk Albrecht Birgit Voigt Michael Hecker Mirja Salkinoja‐Salonen Peter Neubauer 《Proteomics》2010,10(3):555-563
2‐DE reference maps for Deinococcus geothermalis cytosolic and cell envelope proteomes were constructed. In total, 403 spots were identified as 299 different proteins. Unique in the proteomes were four subunits of V‐type ATPase and Deinococcus specific proteins constituting one‐fourth of cell envelope proteome. The cytoplasmic proteome included enzymes of the central carbon metabolism, chaperones, enzymes of protein and DNA repair, and oxidative stress. A total of 34 abundant proteins with unknown function may relate to the extreme stress tolerance of D. geothermalis. 相似文献
163.
164.
165.
Monika Martiniaková Radoslav Omelka Birgit Grosskopf Alena Jančová 《Acta veterinaria Scandinavica》2010,52(1):58
Background
Free-living wild rodents are often used as zoomonitors of environmental contamination. In the present study, accumulation of cadmium (Cd), copper (Cu), iron (Fe), and zinc (Zn) in critical organs of yellow-necked mice (Apodemus flavicollis) and bank voles (Myodes glareolus) trapped in a polluted area in Nováky, Slovakia was investigated. 相似文献166.
Nicholas Schramek Huahong Wang Werner Römisch-Margl Birgit Keil Tanja Radykewicz Bernhard Winzenhörlein Ludger Beerhues Adelbert Bacher Felix Rohdich Jonathan Gershenzon Benye Liu Wolfgang Eisenreich 《Phytochemistry》2010,71(2-3):179-187
Artemisinin from Artemisia annua has become one of the most important drugs for malaria therapy. Its biosynthesis proceeds via amorpha-4,11-diene, but it is still unknown whether the isoprenoid precursors units are obtained by the mevalonate pathway or the more recently discovered non-mevalonate pathway. In order to address that question, a plant of A. annua was grown in an atmosphere containing 700 ppm of 13CO2 for 100 min. Following a chase period of 10 days, artemisinin was isolated and analyzed by 13C NMR spectroscopy. The isotopologue pattern shows that artemisinin was predominantly biosynthesized from (E,E)-farnesyl diphosphate (FPP) whose central isoprenoid unit had been obtained via the non-mevalonate pathway. The isotopologue data confirm the previously proposed mechanisms for the cyclization of (E,E)-FPP to amorphadiene and its oxidative conversion to artemisinin. They also support deprotonation of a terminal allyl cation intermediate as the final step in the enzymatic conversion of FPP to amorphadiene and show that either of the two methyl groups can undergo deprotonation. 相似文献
167.
Markus H Hoffmann Rudolf Hopf Birgit Niederreiter Heinz Redl Josef S Smolen Günter Steiner 《Arthritis research & therapy》2010,12(2):R41
Introduction
Pristane-induced arthritis (PIA) in the rat has been described as an animal model of inflammatory arthritis which exhibits features similar to rheumatoid arthritis in humans, such as a chronic, destructive, and symmetrical involvement of peripheral joints. However, so far little is known about the earliest inflammatory events and their influence on locomotor behaviour during the course of PIA. To investigate this issue a detailed analysis of the pathologic changes occurring during the prodromal and early stages of PIA was performed. 相似文献168.
Birgit Riepl Susanne Grässel Reiner Wiest Martin Fleck Rainer H Straub 《Arthritis research & therapy》2010,12(3):R110
Introduction
Neutrophils and monocytes play an important role in overt inflammation in chronic inflammatory joint diseases such as rheumatoid arthritis (RA). The sympathetic nervous system (SNS) inhibits many neutrophil/monocyte functions and macrophage tumor necrosis factor (TNF), but because of the loss of sympathetic nerve fibers in inflamed tissue, sympathetic control is attenuated. In this study, we focused on noradrenergic and TNF regulation of human neutrophil peptides 1-3 (HNP1-3), which are proinflammatory bactericidal α-defensins. 相似文献169.
170.