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211.
Haitao Li Feng Zhu Yanwen Sun Bing Li Naomi Oi Hanyong Chen Ronald A. Lubet Ann M. Bode Zigang Dong 《PloS one》2013,8(10)
Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly raised: why has the lifelong use of phytochemicals that likely inhibit COX-2 presumably not been associated with adverse cardiovascular side effects. To answer this question, we selected a library of dietary-derived phytochemicals and evaluated their potential cardiovascular toxicity in human umbilical vein endothelial cells. Our data indicated that the possibility of cardiovascular toxicity of these dietary phytochemicals was low. Further mechanistic studies revealed that the actions of these phytochemicals were similar to aspirin in that they mainly inhibited COX-1 rather than COX-2, especially at low doses. 相似文献
212.
Wan Yingling Zhang Min Hong Aiying Lan Xinyu Yang Huiyan Liu Yan 《Plant molecular biology》2020,102(3):239-252
Plant Molecular Biology - Lack of structural components results in inflorescence stem bending. Differentially expressed genes involved in lignin and hemicellulose biosynthesis are vital; genes... 相似文献
213.
Yao Huang Min Pan Hao Shu Bing He Fucheng Zhang Luning Sun 《Journal of cellular biochemistry》2020,121(3):2343-2353
Local angiogenesis following rotator cuff reconstruction is crucial for tendon-bone healing. The current research on the mechanism underlying angiogenesis that promotes tendon-bone healing is scarce. This study investigates the mechanism underlying vascular endothelial growth factor (VEGF)-Hippo signaling pathway's involvement in tendon-bone healing following rotator cuff reconstruction. Verteporfin, the inhibitor of the Yes-associated protein (YAP), was used to mechanically test and analyze two groups of tensile-failure loads following rotator cuff reconstruction and to detect collagen and angiogenesis-related marker expressions in the tendon. The interaction mechanism of the VEGF-Hippo signaling pathway was assessed using human umbilical vein endothelial cells (HUVECs). The diameter of the supraspinatus tendon reduced following verteporfin treatment. Mechanical tests revealed that verteporfin significantly reduces the tensile-failure load of the supraspinatus tendon. Verteporfin significantly reduces collagen 1 (Col 1), Col 3, Angiopoietin 2, CD31, Von Willebrand factor, CTGF, and CYR61 expressions. In HUVECs, VEGF activates VEGF receptors and inhibits LATS and YAP phosphorylation. YAP is then transferred to the nucleus to further activate downstream pathways. Therefore, verteporfin can inhibit VEGF-induced YAP pathway activation by inhibiting YAP activity. Angiogenesis in tendon-bone healing following rotator cuff reconstruction requires VEGF-Hippo signaling pathway synergy. 相似文献
214.
Li Yingxue Xu Ping Wan Zhenzhou Du Hong Jin Xia Zhang Chiyu 《Molecular biology reports》2020,47(10):7341-7348
Molecular Biology Reports - Simple, multiplex qPCR methods are advantages for rapid molecular diagnosis of multiple antibiotics-resistant genes simultaneously. However, the number of genes can be... 相似文献
215.
Lu Haotian Shi Chunying Wang Shuang Yang Chaochao Wan Xueqi Luo Yunzhe Tian Le Li Ling 《Molecular biology reports》2020,47(10):7831-7842
Molecular Biology Reports - Non-SMC condensin I complex subunit H (NCAPH) is a structural component of chromosomes during mitosis, which up-regulates in various cancers. However, the role of NCAPH... 相似文献
216.
Li-Min Lu Hai-Hua Hu Dan-Xiao Peng Bing Liu Jian-Fei Ye Tuo Yang Hong-Lei Li Miao Sun Stephen A. Smith Pamela S. Soltis Douglas E. Soltis Zhi-Duan Chen 《Journal of Biogeography》2020,47(10):2286-2291
In response to our paper on the evolutionary history of the Chinese flora, Qian suggests that certain features of the divergence time estimation employed might have led to biased conclusions in Lu et al (2018). Here, we consider Qian's specific criticisms, explore the extent of uncertainty in the data and demonstrate that (i) no systematic bias toward dates that are too young or too old is detected in Lu et al.; (ii) constraint of the crown age of angiosperms does not bias the generic ages estimated by Lu et al.; and (iii) ages derived from the Chinese regional phylogeny do not bias the conclusions reported by Lu et al. All these analyses confirm that the conclusions reported previously are robust. We argue that, like many large-scale biodiversity analyses, sources of noise in divergence time estimation are to be expected, but these should not be confused with bias. 相似文献
217.
Chen Jiajia Yang Saishuai Wu Chunshuai Cui Zhiming Wan Yangyang Xu Guanhua Bao Guofeng Zhang Jinlong Chen Chu Song Dianwen 《Neurochemical research》2020,45(10):2302-2311
Neurochemical Research - Spinal cord injury (SCI) is one of the diseases with high probability of causing disability in human beings, and there is no reliable treatment at present. Neuronal... 相似文献
218.
Li Rong Wu Bing He Miaoqing Zhang Peng Zhang Qinbin Deng Jing Yuan Jinxian Chen Yangmei 《Neurochemical research》2020,45(9):1997-2008
Neurochemical Research - The number of γ-aminobutyric acid type A receptors (GABAARs) expressed on the surface membrane and at synaptic sites is implicated in the enhanced excitation of... 相似文献
219.