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151.
Ismail Yener Mustafa Abdullah Yilmaz Ozge Tokul Olmez Mehmet Akdeniz Fetullah Tekin Nesrin Hasimi Mehmet Huseyin Alkan Mehmet Ozturk Abdulselam Ertas 《化学与生物多样性》2020,17(3)
Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the chemical composition and biological activities of the essential oils obtained from sixteen Achillea species (A. biebersteinii, A. wilhelmsii subsp. wilhelmsii, A. aleppica subsp. zederbaueri, A. vermicularis, A. monocephala, A. nobilis, A. goniocephala, A. sintenisii, A. coarctata, A. kotschyi subsp. kotschyi, A. millefolium subsp. millefolium, A. lycaonica, A. spinulifolia, A. teretifolia, A. setacea, and A. schischkinii). Anticholinesterase, antiurease, antityrosinase enzymes inhibition, antioxidant, antimicrobial, toxic and cytotoxic activities of obtained essential oils were investigated. DPPH activities were found to be very low in all studied samples, while ABTS and CUPRAC antioxidant activities were found to be moderate. In addition, all samples were found to have moderate anticholinesterase and antimicrobial effects. It has been determined that the studied species have low cytotoxicity and high toxicity. Besides, chemical composition of the essential oils were determined by GC/MS and the results were chemometrically analyzed. The chemometric analyses of Achillea species collected from nine different regions were accomplished by principal component analysis (PCA) and hierarchical cluster analysis (HCA) techniques. According to the PCA analysis, A. nobilis subsp. neilreichii was found to be different from all studied species in terms of essential oil composition. The major components found in these species were piperitone, camphor, α‐terpinene, eucalyptol, artemisia ketone, endo‐borneol, β‐eudesmol and verbenol. The fact that camphor was toxic and found in majority of the studied species stands out as a remarkable result. 相似文献
152.
153.
Sugata Roy Sebastian Schmeier Erik Arner Tanvir Alam Suraj P. Parihar Mumin Ozturk Ousman Tamgue Hideya Kawaji Michiel?J.?L. de?Hoon Masayoshi Itoh Timo Lassmann Piero Carninci Yoshihide Hayashizaki Alistair?R. R. Forrest Vladimir B. Bajic Reto Guler FANTOM Consortium Frank Brombacher Harukazu Suzuki 《Nucleic acids research》2015,43(14):6969-6982
154.
AbstractWe investigated the effects of alpha lipoic acid (ALA) on blood and lung tissue exposed chronically to cigarette smoke (CS). Female Sprague-Dawley rats were divided into three groups. Group 1 was the control group (CON): fresh air was supplied twice daily and 0.1 ml physiological saline was given orally for 8 weeks. Group 2 was exposed to CS: 12 cigarettes were smoked daily at two sessions for 1 h and 0.1 ml saline was given orally for 8 weeks. Group 3 (CS + ALA) was exposed to 12 cigarettes daily in two sessions for 1 h and 100 mg/kg/day ALA was given orally for 8 weeks. DNA damage was assessed using comet analysis; oxidative damage was assessed using ischemia-modified albumin (IMA) from blood; and total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were measured in blood and lung tissue. Histopathological and immunohistochemical evaluation of hypoxia-inducible factor (HIF)-1α, and ?2α, caspase-3, vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF2) were conducted using lung tissue. The oxidative markers, TOS, OSI and IMA, and the comet analysis score were increased and the TAS level was decreased in the blood of the CS group compared to the CON group. IMA levels in blood, and TOS and OSI levels in the lung were decreased significantly in the CS + ALA group compared to the CS group. We observed increased septal wall thickness, marked and diffuse inflammatory reaction, emphysema, and necrotic cell debris in bronchial and bronchiolar lumens in the CS group. HIF-1α, HIF-2α, caspase-3 and FGF2 expressions were increased, while VEGF expression decreased in the lung tissues of the CS group compared to the CON group. ALA slightly ameliorated the damage caused by chronic exposure to CS in the lungs, but further investigation is needed to determine its possible protective effects at different dosages. 相似文献
155.
Stuart J. Lucas Kadriye Kahraman Bihter Avşar Richard J.A. Buggs Ipek Bilge 《The Plant journal : for cell and molecular biology》2021,105(5):1413-1430
The European hazelnut (Corylus avellana L.) is a tree crop of economic importance worldwide, but especially for northern Turkey, where the majority of production takes place. Hazelnut production is currently challenged by environmental stresses, such as a recent outbreak of severe powdery mildew disease; furthermore, allergy to hazelnuts is an increasing health concern in some regions. In order to provide a foundation for using the available hazelnut genetic resources for crop improvement, we produced a fully assembled genome sequence and annotation for a hazelnut species, from C. avellana cv. ‘Tombul’, one of the most important Turkish varieties. A hybrid sequencing strategy, combining short reads, long reads and proximity ligation methods, enabled us to resolve heterozygous regions and produce a high-quality 370-Mb assembly that agrees closely with cytogenetic studies and genetic maps of the 11 C. avellana chromosomes, and covers 97.8% of the estimated genome size. The genome includes 27 270 high-confidence protein-coding genes, over 20 000 of which were functionally annotated based on homology with known plant proteins. We focused particularly on gene families encoding hazelnut allergens, and the Mildew resistance Locus O (MLO) proteins that are an important susceptibility factor for powdery mildew. The complete assembly enabled us to differentiate between members of these families and to identify homologues that may be important in mildew disease and hazelnut allergy. These findings provide examples of how the genome can be used to guide research and to develop effective strategies for crop improvement in C. avellana. 相似文献
156.
Unal Esra Aslan Ezgi Irmak Ozturk Tulin Kurnaz Gomleksiz Ozlem Kucukhuseyin Ozlem Tuzuner M. Bora Seyhan M. Fatih Ozturk Oguz Yilmaz Aydogan Hulya 《Biochemical genetics》2021,59(6):1413-1426
157.
Journal of Ichthyology - The diversity of eight microsatellite DNA loci was analyzed to assess the contemporary level of reproductive isolation between the sockeye salmon with lower numbers... 相似文献
158.
Budama-Kilinc Yasemin Kecel-Gunduz Serda Cakir-Koc Rabia Aslan Bahar Bicak Bilge Kokcu Yagmur Ozel Aysen E. Akyuz Sevim 《International journal of peptide research and therapeutics》2021,27(3):2015-2028
International Journal of Peptide Research and Therapeutics - The aim of the current study was to design a drug delivery nano-system of natural growth-modulating peptide known as GHK that naturally... 相似文献
159.
The effect of temperature on photosynthetic induction under fluctuating light in Chrysanthemum morifolium 总被引:1,自引:0,他引:1
The photosynthetic response was investigated on Chrysanthemum morifolium under dynamic light conditions in the 20–35 °C temperature range to evaluate the effect of climatic variables on photosynthetic induction. The plant material was grown under uniform, controlled conditions and its gas exchange was analyzed. The gas exchange measurements were used to investigate the rate of induction, momentary induction state, and the opening of stomata. At the varying temperature ranges and under dynamic light conditions, C. morifolium reached a quasi-steady-state induction equilibrium (ISeq(PAR,T)) within 14–45 min. For the same level of photosynthetically active radiation (PAR), the equilibrated level of steady-state induction increased as the temperature increased. It was highest approximately at 30 °C. The induction state was equilibrated at a lower level as the temperature increased to 35 °C. The interaction effect of PAR and temperature on induction state was not significant. The rate of photosynthetic induction and the time required at which the induction reached its 90 % value (t 90) was influenced by PAR significantly. The light history of a leaf had a significant effect on t 90, indicating that the time to reach a steady-state induction is different depending on the light environment and the period at which the leaf was exposed to light. The velocity of the photosynthetic induction was not affected by the temperature. It was associated with stomatal conductance of the leaf prior to the onset of light (g Sini). 相似文献
160.
Oguz Ozturk Emel Canbay Ozlem T. Kahraman M. Fatih Seyhan Fatih Aydogan Varol Celik Cihan Uras 《Molecular biology reports》2013,40(2):1813-1818
Although HER2/PTEN pathway is commonly disrupted in cancer, association of HER2 and PTEN polymorphisms with breast cancer (BC) remains controversial. We investigated the HER2 Ile655 Val and PTEN IVS4 polymorphisms in patients with BC in Turkish population. HER2 Ile655Val (rs 1136201) and PTEN IVS4 (rs 3830675) polymorphisms were determined using polymerase chain reaction-based restriction fragment length polymorphism (PCR–RFLP) in blood samples of 118 BC patients and 118 age-matched healthy controls. We found that the frequency of the Ile/Val genotype of HER2 Ile655Val gene was significantly higher in BC patients (p < 0.009; OR: 1,983 95 % CI: 1.181—3.328). The presence of ATCTT insertion (+/+) genotype at downstream of exon 4 in intron 4 of PTEN IVS4 gene was also associated with 1.83 fold decreased risk of BC development (p < 0.033; OR: 1.83, 95 % CI: 1.11—3.03). Analysis on clinico-pathological parameters showed neither HER2 Ile655Val nor PTEN IVS4 genotypes were not associated with any of the variables (p > 0.05).In conclusion, our findings suggest that the Ile/Val genotype of HER2 and ATCTT insertion (+/+) genotype of PTEN IVS4 gene may play an important role as genetic markers for breast cancer risk, but both genes genotypes may not be useful for predicting tumor prognosis in Turkish population. 相似文献