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排序方式: 共有191条查询结果,搜索用时 31 毫秒
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Stochastic multiscale modelling of cortical bone elasticity based on high-resolution imaging 总被引:1,自引:0,他引:1
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Y. J. Bignon P. Souteyrand H. Roger D. Bernard B. Dastugue F. Ramos M. d'Incan P. Chollet R. Plagne 《Human genetics》1990,84(2):177-178
Summary Genomic DNA digests of skin biopsies from 20 patients with cutaneous T-cell lymphomas and pseudolymphomas were studied by hybridization, using probes for the constant region of the T-cell receptor beta chain and the joining region of the immunoglobin heavy chain gene. Skin biopsies from all 20 patients contained a monoclonal T-cell population. In addition, DNA from 5 patients contained an immunoglobulin gene rearrangement. These results demonstrate that cutaneous T-cell lymphomas are clonal T-cell malignancies that frequently express a dual genotype, which may sometimes reflect the clonotypic heterogeneity of these disorders. 相似文献
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M C Jaurand L Magne J Bignon 《Comptes rendus des séances de la Société de biologie et de ses filiales》1980,174(4):488-493
Understanding of the biological effects of fibres has been archievied due to a large number of in vitro (cytotoxicity on free cells) and experimental studies. However, the basic mechanisms are still unknown. Results showed that fibres act on various levels, nuclear, metabolic, immunologic or molecular. 相似文献
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M C Jaurand A Renier A Van der Meeren L Magne M C Pinchon J Bignon 《Biology of the cell / under the auspices of the European Cell Biology Organization》1986,57(3):249-256
The study reports morphological growth characteristics and chromosome analysis of neoplastic rat pleural mesothelial cells (RPMC) isolated from a mesothelioma-bearing rat. The pleural mesothelioma was induced by intrapleural injection of chrysotile fibers. Neoplastic RPMC were cultured by the standard methods used for normal RPMC. Neoplastic RPMC cultures had a population doubling time of 19 hr versus 30 hr for the normal cells. Plating efficiency in liquid medium was almost 100%. Cultures of neoplastic RPMC were anchorage-independent since 70% of the seeded cells formed colonies after one week; after the second week, colony size was enhanced but colony recovery was not. The serum dependence of neoplastic cells was less than that of the normal cells. 79 out of 100 metaphase cells analyzed had 41 to 43 chromosomes, and the modal number was 42 (38%). A large metacentric chromosome was observed in 77 of the 100 neoplastic metaphase cells analyzed, but not in any normal metaphase cells. In nude mice, the neoplastic RPMC were tumorigenic. 相似文献
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