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71.
The problem of regulation of cell division is essentially a problem of understanding regulation of transition from the resting state of a cell to the dividing state and vice versa. In malignancy the ability to revert back to a normal resting state is impaired. A model is presented which attempts to explain the control of the above transitions through control of uptake of essential nutrients by a transport-inhibitory protein. Experimental evidence in favour of the model is given. 相似文献
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Small amounts of metabolite-binding protein (MBP) originally characterized from the bile were detected in rat serum and cytosol by an indirect enzyme-linked immunoabsorbant assay. The site of MBP synthesis was shown to be the liver based upon results of (1) the in vitro translation of liver poly(A)+ mRNA, followed by immunoprecipitation with anti-MBP sera and sodium dodecyl sulfate-polyacrylamide gel electrophoresis and fluorography of the immunoprecipitate, and (2) immunoprecipitation of bile collected from [3H]leucine perfused liver in situ and SDS-polyacrylamide gel electrophoresis and fluorography of the immunoprecipitate. To determine whether part of the MBP in bile is derived from the circulation, [125I]MBP was injected intravenously and bile was collected and subjected to SDS-polyacrylamide gel electrophoresis and fluorography. Intact [125]MBP was not detected in bile even though several other iodinated bile proteins were taken up by the liver from the circulation and secreted intact into the bile under similar experimental conditions. These data indicate that MBP is synthesized in the liver and secreted into the bile and circulation independently. In addition, MBP was not found in brain, spleen or kidneys. 相似文献
74.
Naohito Ohmi Bhargava M. Madhu Irwin M. Arias 《Biochimica et Biophysica Acta (BBA)/General Subjects》1981,675(2):276-280
Following administration of phenobarbital to rats, liver ligandin content, bilirubin binding, glutathione-S-transferase and steriod isomerase activities by 150% and the 22 000-dalton subunit was selectively increased. Following adminstration of 3′-methyl-N,N-dimethyl-4-aminoazobenzene, rat liver ligandin content and steroid isomerase decrased by 65%, glutathione-S-transferase incrased by 100%, bilirubin binding was abolished, and the relative proportion of the 22 000- and 25 000-dalton subunits remained unchanged. 相似文献
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S. C. Bhargava S. N. Saxena R. Sharma 《Journal of plant biochemistry and biotechnology.》2003,12(1):43-47
A method of microcloning via somatic embryogenesis was established in date palm (Phoenix dactylifera L) cultivars. The method has potential for commercial application. Embryogenic cultures were initiated from soft primordial tissues of 2-3-year-old female suckers. The system was optimized first for the genotype ’sayar’ and then its applicability was tested to other genotypes. A method of pre-acclimation using pre-acclimation chambers has been devised, which improved hardening survival greatly. More than 80 clones obtained from the genotype ’sayar’ have been shifted to field for agronomic evaluation. 相似文献
78.
Girish B. Chhed Helen B. Patrzyc Arvind K. Bhargava Pamela F. Crain Satinder K. Sethi James A. McCloskey 《Nucleosides, nucleotides & nucleic acids》2013,32(3):597-611
Abstract From 24 hour collections of urines of chronic myelogenous leukemia (CML) patients, a novel nucleoside was isolated. It was assigned the structure, 5′-deoxyinosine (I) on the basis of UV, NMR and mass spectrometry and by comparison of the spectral data and HPLC and TLC mobilities with those of the authentic sample. Another nucleoside, 5′-deoxy-5′-methylthioadenosine sulfoxide previously isolated from the urines of immunodeficient children was also found in the urine of a CML patient. Possible origin and significance of both of these nucleosides are discussed. 相似文献
79.
S. S. Pant A. N. Bhargava M. M. Singh P. C. Dhanda 《BMJ (Clinical research ed.)》1963,1(5337):1064-1065
80.
Melanoma is the most lethal cutaneous cancer with a highly aggressive and metastatic phenotype. While recent genetic and epigenetic studies have shed new insights into the mechanism of melanoma development, the involvement of regulatory non‐coding RNAs remain unclear. Long non‐coding RNAs (lncRNAs) are a group of endogenous non‐protein‐coding RNAs with the capacity to regulate gene expression at multiple levels. Recent evidences have shown that lncRNAs can regulate many cellular processes, such as cell proliferation, differentiation, migration and invasion. In the melanoma, deregulation of a number of lncRNAs, such as HOTAIR, MALAT1, BANCR, ANRIL, SPRY‐IT1 and SAMMSON, have been reported. Our review summarizes the functional role of lncRNAs in melanoma and their potential clinical application for diagnosis, prognostication and treatment. 相似文献