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151.
152.
Bhargava A 《BMJ (Clinical research ed.)》2000,321(7270):1225; author reply 1226-1225; author reply 1227
153.
Role of the N- and C-terminal extensions on the activity of mammalian mitochondrial translational initiation factor 3 总被引:1,自引:1,他引:0
Mammalian mitochondrial translational initiation factor 3 (IF3mt) promotes initiation complex formation on mitochondrial 55S ribosomes in the presence of IF2mt, fMet-tRNA and poly(A,U,G). The mature form of IF3mt is predicted to be 247 residues. Alignment of IF3mt with bacterial IF3 indicates that it has a central region with 20–30% identity to the bacterial factors. Both the N- and C-termini of IF3mt have extensions of ~30 residues compared with bacterial IF3. To examine the role of the extensions on IF3mt, deletion constructs were prepared in which the N-terminal extension, the C-terminal extension or both extensions were deleted. These truncated derivatives were slightly more active in promoting initiation complex formation than the mature form of IF3mt. Mitochondrial 28S subunits have the ability to bind fMet-tRNA in the absence of mRNA. IF3mt promotes the dissociation of the fMet-tRNA bound in the absence of mRNA. This activity of IF3mt requires the C-terminal extension of this factor. Mitochondrial 28S subunits also bind mRNA independently of fMet-tRNA or added initiation factors. IF3mt has no effect on the formation of these complexes and cannot dissociate them once formed. These observations have lead to a new model for the function of IF3mt in mitochondrial translational initiation. 相似文献
154.
DAS M Bhargava N Gregory C Riedel L Molnar P Hickman JJ 《In vitro cellular & developmental biology. Animal》2005,41(10):343-348
Summary In this study, we have documented by morphological analysis, immunocytochemistry, and electrophysiology, the development of
a culture system that promotes the growth and long-term survival of dissociated adult rat spinal cord neurons. This system
comprises a patternable, nonbiological, cell growth-promoting organosilane substrate coated on a glass surface and an empirically
derived novel serum-free medium, supplemented with specific growth factors (acidic fibroblast growth factor, heparin sulfate,
neurotrophin-3, brain-derived neurotrophic factor, glial-derived neurotrophic factor, cardiotrophin-1, and vitronectin). Neurons
were characterized by immunoreactivity for neurofilament 150, neuron-specific enolase, Islet-1 antibodies, electrophysiology,
and the cultures were maintained for 4–6 wk. This culture system could be a useful tool for the study of adult mammalian spinal
neurons in a functional in vitro system. 相似文献
155.
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159.
The central serotonergic neurones seem to have important regulatory function on the cardiovascular system. Since human blood platelets and serotonin (5-HT) containing neurones in the central nervous system have numerous similarities, the uptake of serotonin by human platelets was investigated in normal subjects and in patients of essential hypertension. The 5-HT content of platelets as well as 5-HT uptake by the platelets were significantly reduced in hypertensive subjects as compared to control. It appears that a deficiency of serotonin centrally may lead to disinhibition of the serotonergic mechanisms leading to hypertension. Moreover, a decreased activity of serotonergic neurones may co-exist with an over-activity of catecholaminergic neurones in essential hypertension, which is discussed. This is probably the first report of altered serotonin mechanism in clinical hypertension. 相似文献
160.
C R Rao L D Visweshwaraiah K S Veerapaiah S D Satpute D Hazarika M K Bhargava 《Acta cytologica》1990,34(5):681-684
A five-month-old male child presented with a tumor of the maxilla, which was clinically diagnosed as an eruption cyst or a rhabdomyosarcoma. Fine needle aspiration smears showed two types of cells: neuroblastlike cells and cells containing melanin pigment. A cytologic diagnosis of melanotic neuroectodermal tumor of infancy was made. This diagnosis was confirmed by histopathologic examination of the subsequently excised mass. 相似文献