全文获取类型
收费全文 | 170篇 |
免费 | 14篇 |
国内免费 | 3篇 |
专业分类
187篇 |
出版年
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2016年 | 7篇 |
2015年 | 6篇 |
2014年 | 12篇 |
2013年 | 15篇 |
2012年 | 11篇 |
2011年 | 14篇 |
2010年 | 12篇 |
2009年 | 10篇 |
2008年 | 8篇 |
2007年 | 7篇 |
2006年 | 8篇 |
2005年 | 3篇 |
2004年 | 3篇 |
2003年 | 6篇 |
2002年 | 8篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1984年 | 1篇 |
1983年 | 4篇 |
1981年 | 1篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有187条查询结果,搜索用时 8 毫秒
71.
Massullo P Sumoza-Toledo A Bhagat H Partida-Sánchez S 《Seminars in cell & developmental biology》2006,17(6):654-666
Melastatin-related TRPM ion channels have emerged as novel therapeutic targets due to their potential ability to modulate the function and fate of immune cells during inflammation, innate, and adaptive immunity. Four family members, TRPM1, TRPM2, TRPM4 and TRPM7 have a strong presence in the immune system. TRPM channels regulate ion-homeostasis by sensing cellular redox status and cytoplasmic calcium levels. TRPM2 for example, is highly expressed in phagocytes. This channel is activated by intracellular ADP-ribose upon exposure to oxidative stress and induces cell death. Here we will review the functional links between TRPM-mediated ion conductance, chemotaxis, apoptosis, and innate immunity. 相似文献
72.
73.
Verma Deepanjali Bhagat Prakash Kumar Sinha Alok Krishna 《Journal of plant biochemistry and biotechnology.》2020,29(4):785-795
Journal of Plant Biochemistry and Biotechnology - Involvement of MAPK cascades is well studied in the regulation of ABA mediated responses such as stomatal opening, seed germination and stress... 相似文献
74.
S Jahan S Singh A Srivastava V Kumar D Kumar A Pandey CS Rajpurohit AR Purohit VK Khanna AB Pant 《Molecular neurobiology》2018,55(4):2828-2839
75.
M. V. Singh S. B. Rawal A. K. Tyagi Maj J. K. Bhagat R. Parshad H. M. Divekar 《International journal of biometeorology》1988,32(1):36-40
Studies were carried out in 29 healthy young adults in the Indian Army stationed in the plains and posted at an elevation of 3500 m for more than 6 months. After exposure to a low elevation in Delhi (260 m) for 3 weeks they were reinduced to a height of 3500 m. The subjects were divided into three groups, each of which was treated with either placebo or acetazolamide or spironolactone. The drug treatment was started immediately after their landing at high altitude and continued for 2 days only. Total body water, extracellular fluid, intracellular fluid, plasma volume, blood pH, PaO2, PaCO2 and blood viscosity were determined on exposure at Delhi and on re-induction to high altitude. Plasma volume was increased after the descent from high altitude and remained high for up to 21 day's study. This increased plasma volume may have some significance in the pathogenesis of pulmonary oedema. Total body water and intracellular fluid content were increased at 260 m elevation, while extracellular fluid decreased. On re-induction there was a decrease in total body water with no change in the extracellular fluid content.This paper was presented in part at the 17th annual conference of the Society of Nuclear Medicine, India held at Bangalore, January 2–4, 1986 相似文献
76.
77.
Inter‐microcarrier transfer and phenotypic stability of stem cell‐derived Schwann cells in stirred suspension bioreactor culture 下载免费PDF全文
78.
In adult rats, removal of one ovary leads to an acute albeit transient rise in serum follicle stimulating hormone and an increase
in the weight of the remaining ovary. In an attempt to correlate the high titre of endogenous follicle stimulating hormone
with the changes taking place at the macromolecular level, the phenomenon of compensatory ovarian hypertrophy was studied
for one cycle after hemiovariectomy at metoestrus in the adult, cycling female rats derived from the Holtzman strain. The
significant finding with respect to hormonal changes was an acute follicle stimulating hormone surge commencing 6h post-unilateral
ovariectomy, reaching a maximum at 12 h and declining thereafter, hitherto not reported in the Holtzman strain. Serum luteinizing
hormone, prolactin, oestradiol-17β and testosterone remained unaltered while progesterone showed a decline at 6 h after surgery.
There was an increase in the number of healthy class III (> 350 μm) follicles with a concomitant drop in atretic class III
follicles 24 h post-unilateral ovariectomy. Analysis for DNA, RNA and protein content showed that all three constituents registered
a continuous rise in the hypertrophying ovary up to 120h after surgery. When expressed as ?g/mg ovarian weight, the increase
in DNA reached a maximum at 24 h and declined thereafter. The kinetics of DNA synthesis was followed by pulse labelling with
[3H] thymidine at 18, 24, 36 and 48 h after unilateral ovariectomy. Maximum incorporation occurred at 36 h. Autoradiographic
studies showed that the granulosa cells of healthy follicles preferentially incorporated the label. In an extension of this
study, it was found that labelling index registered a significant increase following ovariectomy, the maximum being reached
at 24 h especially in classIII follicles. The results clearly point out the crucial role of hyperplasia in the response of the contralateral ovary to the
surgery and implicate the rise in follicle stimulating hormone as the primary signal for initiation of such a response. This
raises the question whether in compensatory ovarian hypertrophy follicle stimulating hormone has a mitogenic role 相似文献
79.
M?nica G Campiteli Frederico M Soriani Iran Malavazi Osame Kinouchi Carlos AB Pereira Gustavo H Goldman 《BMC bioinformatics》2009,10(1):270
Background
Microarray techniques have become an important tool to the investigation of genetic relationships and the assignment of different phenotypes. Since microarrays are still very expensive, most of the experiments are performed with small samples. This paper introduces a method to quantify dependency between data series composed of few sample points. The method is used to construct gene co-expression subnetworks of highly significant edges. 相似文献80.
Krishna Kumar N. Amaresan S. Bhagat K. Madhuri R. C. Srivastava 《Indian journal of microbiology》2012,52(2):137-144
Trichoderma, soil-borne filamentous fungi, are capable of parasitising several plant pathogenic fungi. Twelve isolates of Trichoderma spp. isolated from different locations of South Andaman were characterized for their cultural, morphological and antagonistic activity against soil borne and foliar borne pathogens. The sequencing of these isolates showed seven different species. The isolates revealed differential reaction patterns against the test pathogens viz., Sclerotium rolfsii, Colletotrichum gloeosporioides and C. capsici. However, the isolates, TND1, TWN1, TWC1, TGD1 and TSD1 were most effective in percentage inhibition of mycelial growth of test pathogens. Significant chitinase and β-1,3-glucanase activities of all Trichoderma isolates has been recorded in growth medium. T. viride was found with highest chitinase whereas T. harzianum was recorded with highest β-1,3-glucanase activities. 相似文献