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Integrins: Structure and Signaling 总被引:7,自引:0,他引:7
Integrins are cell surface transmembrane glycoproteins that function as adhesion receptors in cell-extracellular matrix interactions and link the matrix proteins to the cytoskeleton. The family of human integrins comprises 24 members, each of which is a heterodimer consisting of 1 of 18 alpha- and 1 of 8 beta-subunits. Integrins play an important role in the cytoskeleton organization and in transduction of intracellular signals, regulating various processes such as proliferation, differentiation, apoptosis, and cell migration. This review summarizes current views on the structure of integrins, integrin associated proteins, and biochemical mechanisms underlying their signaling functions. 相似文献
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Berman BM 《BMJ (Clinical research ed.)》2001,322(7279):121-122
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Bishop MJ Berman J Bigham EC Garrison DT Gobel MJ Hodson SJ Irving PE Liacos JA Minick DJ Navas F Saussy DL Speake JD 《Bioorganic & medicinal chemistry letters》2001,11(21):2871-2874
2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified. 相似文献
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Bishop MJ Barvian KA Berman J Bigham EC Garrison DT Gobel MJ Hodson SJ Irving PE Liacos JA Navas F Saussy DL Speake JD 《Bioorganic & medicinal chemistry letters》2002,12(3):471-475
Novel 2'-heteroaryl-2-(phenoxymethyl)imidazolines have been identified as potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The nature of the 2'-heteroaryl group can have significant effects on the potency, efficacy, and subtype selectivity in this series. alpha(1A) Subtype selective agonists have been identified. 相似文献
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Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier 总被引:6,自引:0,他引:6
Leukocyte transmigration across the blood-brain barrier (BBB) is a multistep process that can be mediated by chemokines. These low-molecular-weight chemoattractant proteins are secreted by cells within the central nervous system (CNS) in response to injury or on activation. Leukocytes transmigrate toward this chemokine gradient, crossing the BBB and gaining access to the CNS parenchyma. Depending on the chemokine, the nature of the insult, and the type of cell that transmigrates, the BBB integrity may be disrupted, leading to its increased permeability. Both the inflammation resulting from leukocyte transmigration and BBB perturbations contribute to CNS pathology. The mechanisms that mediate leukocyte transmigration and BBB disruption, as well as tissue culture models that are used to study leukocyte trafficking, are the focus of this review. 相似文献
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