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排序方式: 共有845条查询结果,搜索用时 16 毫秒
831.
832.
Benedikt Hallgrímsson Heather Jamniczky Nathan M. Young Campbell Rolian Trish E. Parsons Julia C. Boughner Ralph S. Marcucio 《Evolutionary biology》2009,36(4):355-376
Organisms represent a complex arrangement of anatomical structures and individuated parts that must maintain functional associations
through development. This integration of variation between functionally related body parts and the modular organization of
development are fundamental determinants of their evolvability. This is because integration results in the expression of coordinated
variation that can create preferred directions for evolutionary change, while modularity enables variation in a group of traits
or regions to accumulate without deleterious effects on other aspects of the organism. Using our own work on both model systems
(e.g., lab mice, avians) and natural populations of rodents and primates, we explore in this paper the relationship between
patterns of phenotypic covariation and the developmental determinants of integration that those patterns are assumed to reflect.
We show that integration cannot be reliably studied through phenotypic covariance patterns alone and argue that the relationship
between phenotypic covariation and integration is obscured in two ways. One is the superimposition of multiple determinants
of covariance in complex systems and the other is the dependence of covariation structure on variances in covariance-generating
processes. As a consequence, we argue that the direct study of the developmental determinants of integration in model systems
is necessary to fully interpret patterns of covariation in natural populations, to link covariation patterns to the processes
that generate them, and to understand their significance for evolutionary explanation. 相似文献
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G-banding comparisons of 26 species in 10 genera of three tribes of Australian rodents show that at least one representative of each of the three tribes has autosomal complements that are indistinguishable on G-banding, implying unusually high conservation of karyotypes. Three genera (Pseudomys, Notomys, and Mastacomys) are distinguished karyotypically by a reciprocal translocation, one genus (Uromys) by a tandem fusion, and one genus (Zyzomys) by a radically altered karyotype. The only other rearrangements identified from G-banding are pericentric inversions, all 12 of which involve breaks in the proximal area. 相似文献
836.
L L Jahnke W Eder R Huber J M Hope K U Hinrichs J M Hayes D J Des Marais S L Cady R E Summons 《Applied and environmental microbiology》2001,67(11):5179-5189
The molecular and isotopic compositions of lipid biomarkers of cultured Aquificales genera have been used to study the community and trophic structure of the hyperthermophilic pink streamers and vent biofilm from Octopus Spring. Thermocrinis ruber, Thermocrinis sp. strain HI 11/12, Hydrogenobacter thermophilus TK-6, Aquifex pyrophilus, and Aquifex aeolicus all contained glycerol-ether phospholipids as well as acyl glycerides. The n-C(20:1) and cy-C(21) fatty acids dominated all of the Aquificales, while the alkyl glycerol ethers were mainly C(18:0). These Aquificales biomarkers were major constituents of the lipid extracts of two Octopus Spring samples, a biofilm associated with the siliceous vent walls, and the well-known pink streamer community (PSC). Both the biofilm and the PSC contained mono- and dialkyl glycerol ethers in which C(18) and C(20) alkyl groups were prevalent. Phospholipid fatty acids included both the Aquificales n-C(20:1) and cy-C(21), plus a series of iso-branched fatty acids (i-C(15:0) to i-C(21:0)), indicating an additional bacterial component. Biomass and lipids from the PSC were depleted in (13)C relative to source water CO(2) by 10.9 and 17.2 per thousand, respectively. The C(20-21) fatty acids of the PSC were less depleted than the iso-branched fatty acids, 18.4 and 22.6 per thousand, respectively. The biomass of T. ruber grown on CO(2) was depleted in (13)C by only 3.3 per thousand relative to C source. In contrast, biomass was depleted by 19.7 per thousand when formate was the C source. Independent of carbon source, T. ruber lipids were heavier than biomass (+1.3 per thousand). The depletion in the C(20-21) fatty acids from the PSC indicates that Thermocrinis biomass must be similarly depleted and too light to be explained by growth on CO(2). Accordingly, Thermocrinis in the PSC is likely to have utilized formate, presumably generated in the spring source region. 相似文献
837.
Heather A. Jamniczky Benedikt Hallgrímsson 《Evolution; international journal of organic evolution》2009,63(6):1540-1556
Mutations have the ability to produce dramatic changes to covariance structure by altering the variance of covariance-generating developmental processes. Several evolutionary mechanisms exist that may be acting interdependently to stabilize covariance structure, despite this developmental potential for variation within species. We explore covariance structure in the crania of laboratory mouse mutants exhibiting mild-to-significant developmental perturbations of the cranium, and contrast it with covariance structure in related wild muroid taxa. Phenotypic covariance structure is conserved among wild muroidea, but highly variable and mutation-dependent within the laboratory group. We show that covariance structures in natural populations of related species occupy a more restricted portion of covariance structure space than do the covariance structures resulting from single mutations of significant effect or the almost nonexistent genetic differences that separate inbred mouse strains. Our results suggest that developmental constraint is not the primary mechanism acting to stabilize covariance structure, and imply a more important role for other mechanisms. 相似文献
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Anne Clancy Claire Heride Adn Pinto-Fernndez Hannah Elcocks Andreas Kallinos Katherine J. Kayser-Bricker Weiping Wang Victoria Smith Simon Davis Shawn Fessler Crystal McKinnon Marie Katz Tim Hammonds Neil P. Jones Jonathan OConnell Bruce Follows Steven Mischke Justin A. Caravella Stephanos Ioannidis Christopher Dinsmore Sunkyu Kim Axel Behrens David Komander Benedikt M. Kessler Sylvie Urb Michael J. Clague 《The Journal of cell biology》2021,220(3)
When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. The initial stalling and the subsequent resolution of di-ribosomal complexes requires activity of Makorin and ZNF598 ubiquitin E3 ligases, respectively, through ubiquitylation of the eS10 and uS10 subunits of the ribosome. We have developed a specific small-molecule inhibitor of the deubiquitylase USP9X. Proteomics analysis, following inhibitor treatment of HCT116 cells, confirms previous reports linking USP9X with centrosome-associated protein stability but also reveals a loss of Makorin 2 and ZNF598. We show that USP9X interacts with both these ubiquitin E3 ligases, regulating their abundance through the control of protein stability. In the absence of USP9X or following chemical inhibition of its catalytic activity, levels of Makorins and ZNF598 are diminished, and the ribosomal quality control pathway is impaired. 相似文献