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121.
Salehi Majid Garmabi Behzad Jafarisani Moslem Khastar Hossein 《International journal of peptide research and therapeutics》2020,26(3):1607-1612
International Journal of Peptide Research and Therapeutics - Renal ischemia–reperfusion (IR) is a common cause of acute renal failure and result in remote organ injury. Oxidative stress and... 相似文献
122.
Dehghani Behzad Hasanshahi Zahra Hashempour Tayebeh 《International journal of peptide research and therapeutics》2020,26(4):2057-2065
International Journal of Peptide Research and Therapeutics - Melittin is a 26 amino acid amphipathic peptide, the main part of a bee venom. It has been confirmed that melittin can act against a... 相似文献
123.
Imeni Milad Seyfi Behzad Fatouraee Nasser Samani Abbas 《Biomechanics and modeling in mechanobiology》2020,19(6):1979-1996
Biomechanics and Modeling in Mechanobiology - Menisci are fibrocartilaginous disks consisting of soft tissue with a complex biomechanical structure. They are critical determinants of the kinematics... 相似文献
124.
Mohseni Fahimeh Khaksari Mehdi Rafaiee Raheleh Rahimi Kasra Norouzi Pirasteh Garmabi Behzad 《International journal of peptide research and therapeutics》2021,27(2):1351-1362
International Journal of Peptide Research and Therapeutics - Fetal alcohol Spectrum Disorder (FASD) describes the range of detrimental impacts which are likely to occur in children who are born to... 相似文献
125.
Protein-protein ligand is one of the most detection methods used in Nano biosensors. Based on the advantage of specific docking between two special 3D structures, they have become a potent candidate in bioanalysis and Nanodiagnostic tools. These tools lease users to do a simple, fast, cost-effective, sensitive, and specific detection of molecular biomarkers in real samples. Recent advantages of using protein-protein ligand Nano-biosensors application is remarkable due to its special docking that refers to each protein unique 3D conformation. However, it challenges different problems such as low rate of docking and hard process for fixation on the basic layer. These challenges make developers to optimize the structure and functions of proteins. The process has different Nano scale calculation that could be done with algorithms and solutions are available as bioinformatics tools. This article aimed to have a short overview of the abilities of bioinformatics tools for modeling and optimization of physiochemical features of proteins in Nano scale. 相似文献
126.
Michael Mauer Emily Glynn Einar Svarstad Camilla T?ndel Marie-Claire Gubler Michael West Alexey Sokolovskiy Chester Whitley Behzad Najafian 《PloS one》2014,9(11)
Background
Fabry disease. an X-linked deficiency of α-galactosidase A coded by the GLA gene, leads to intracellular globotriaosylceramide (GL-3) accumulation. Although less common than in males, chronic kidney disease, occurs in ∼15% of females. Recent studies highlight the importance of podocyte injury in Fabry nephropathy development and progression. We hypothesized that the greater the % of podocytes with active wild-type GLA gene (due to X-inactivation of the mutant copy) the less is the overall podocyte injury.Methods
Kidney biopsies from 12 treatment-naive females with Fabry disease, ages 15 (8–63), median [range], years were studied by electron microscopy and compared with 4 treatment-naive male patients.Results
In females, 51 (13–100)% of podocytes (PC) per glomerulus had no GL-3 inclusions, this consistent with a non-Fabry podocyte phenotype (NFPC). In PC with GL-3 inclusions [Fabry podocyte phenotype (FPC)], GL-3 volume density per podocyte was virtually identical in females and males, consistent with little or no cross-correction between FPC and NFPC. %NFPC per glomerulus (%NFPC/glom) correlated with age in females (r = 0.65, p = 0.02), suggesting a survival disadvantage for FPC over time. Age-adjusted %NFPC/glom was inversely related to foot process width (FPW) (r = −0.75, p = 0.007), an indicator of PC injury. GL-3 volume density in FPC in females correlated directly with FPW.Conclusions
These findings support important relationships between podocyte mosaicism and podocyte injury in female Fabry patients. Kidney biopsy, by providing information about podocyte mosaicism, may help to stratify females with Fabry disease for kidney disease risk and to guide treatment decisions. 相似文献127.
Sandeep Gupta Shunan Li Md. Joynal Abedin Kajohnsak Noppakun Lawrence Wang Tarundeep Kaur Behzad Najafian Cecília M. P. Rodrigues Clifford J. Steer 《PloS one》2012,7(11)
Background
Acute kidney injury (AKI) has grave short- and long-term consequences. Often the onset of AKI is predictable, such as following surgery that compromises blood flow to the kidney. Even in such situations, present therapies cannot prevent AKI. As apoptosis is a major form of cell death following AKI, we determined the efficacy and mechanisms of action of tauroursodeoxycholic acid (TUDCA), a molecule with potent anti-apoptotic and pro-survival properties, in prevention of AKI in rat and cell culture models. TUDCA is particularly attractive from a translational standpoint, as it has a proven safety record in animals and humans.Methodology/Principal Findings
We chose an ischemia-reperfusion model in rats to simulate AKI in native kidneys, and a human kidney cell culture model to simulate AKI associated with cryopreservation in transplanted kidneys. TUDCA significantly ameliorated AKI in the test models due to inhibition of the mitochondrial pathway of apoptosis and upregulation of survival pathways.Conclusions
This study sets the stage for testing TUDCA in future clinical trials for prevention of AKI, an area that needs urgent attention due to lack of effective therapies. 相似文献128.
129.
Ebrahimi B Li Z Eirin A Zhu XY Textor SC Lerman LO 《American journal of physiology. Renal physiology》2012,302(11):F1478-F1485
Renal artery stenosis (RAS) promotes microvascular rarefaction and fibrogenesis, which may eventuate in irreversible kidney injury. We have shown that percutaneous transluminal renal angioplasty (PTRA) or endothelial progenitor cells (EPC) improve renal cortical hemodynamics and function in the poststenotic kidney. The renal medulla is particularly sensitive to hypoxia, yet little is known about reversibility of medullary injury on restoration of renal blood flow. This study was designed to test the hypothesis that PTRA, with or without adjunct EPC delivery to the stenotic kidney, may improve medullary remodeling and tubular function. RAS was induced in 21 pigs using implantation of irritant coils, while another group served as normal controls (n = 7 each). Two RAS groups were then treated 6 wk later with PTRA or both PTRA and EPC. Four weeks later, medullary hemodynamics, microvascular architecture, and oxygen-dependent tubular function of the stenotic kidneys were examined using multidetector computed tomography, microcomputed tomography, and blood oxygenation level-dependent MRI, respectively. Medullary protein expression of vascular endothelial growth factor, endothelial nitric oxide synthase, hypoxia-inducible factor-1α, and NAD(P)H oxidase p47 were determined. All RAS groups showed decreased medullary vascular density and blood flow. However, in RAS+PTRA+EPC animals, EPC were engrafted in tubular structures, oxygen-dependent tubular function was normalized, and fibrosis attenuated, despite elevated expression of hypoxia-inducible factor-1α and sustained downregulation of vascular endothelial growth factor. In conclusion, EPC delivery, in addition to PTRA, restores medullary oxygen-dependent tubular function, despite impaired medullary blood and oxygen supply. These results support further development of cell-based therapy as an adjunct to revascularization of RAS. 相似文献
130.
Marcel A. Kamp Behzad Shakeri Etienne E. Tevoufouet Andreas Krieger Margit Henry Kerstin Behnke Stefan Herzig Jürgen Hescheler Kayalvizhi Radhakrishnan Lucie Parent Toni Schneider 《Biochimica et Biophysica Acta - Proteins and Proteomics》2012,1824(9):1045-1057
Cav2.3 containing voltage-activated Ca2 + channels are expressed in excitable cells and trigger neurotransmitter and peptide-hormone release. Their expression remote from the fast release sites leads to the accumulation of presynaptic Ca2 + which can both, facilitate and inhibit the influx of Ca2 + ions through Cav2.3. The facilitated Ca2 + influx was recently related to hippocampal postsynaptic facilitation and long term potentiation. To analyze Ca2 + mediated modulation of cellular processes more in detail, protein partners of the carboxy terminal tail of Cav2.3 were identified by yeast-2-hybrid screening, leading in two human cell lines to the detection of a novel, extended and rarely occurring splice variant of calmodulin-2 (CaM-2), called CaM-2-extended (CaM-2-ext). CaM-2-ext interacts biochemically with the C-terminus of Cav2.3 similar to the classical CaM-2 as shown by co-immunoprecipitation. Functionally, only CaM-2-ext reduces whole cell inward currents significantly. The insertion of the novel 46 nts long exon and the consecutive expression of CaM-2-ext must be dependent on a new upstream translation initiation site which is only rarely used in the tested human cell lines. The structure of the N-terminal extension is predicted to be more hydrophobic than the remaining CaM-2-ext protein, suggesting that it may help to dock it to the lipophilic membrane surrounding. 相似文献