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921.
Length‐weight relationships for five Clupeiformes species from the Persian Gulf and Oman Sea 下载免费PDF全文
H. Mousavi‐Sabet H. Homayouni M. Marjani A. Heidari 《Zeitschrift fur angewandte Ichthyologie》2016,32(1):169-170
Length‐weight relationships (LWRs) were determined for five Clupeiformes species representing three families collected from the Persian Gulf and Oman Sea. These are the first references on length‐weight relationships for two of these species (Ilisha megaloptera and Sardinella sindensis). A new maximum length record was obtained for one species (Ilisha melastoma). 相似文献
922.
Carina Proença Marisa Freitas Daniela Ribeiro Eduardo F. T. Oliveira Joana L. C. Sousa Sara M. Tomé 《Journal of enzyme inhibition and medicinal chemistry》2017,32(1):1216-1228
α-Glucosidase inhibitors are described as the most effective in reducing post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used in the management of type 2 diabetes mellitus. As flavonoids are promising modulators of this enzyme’s activity, a panel of 44 flavonoids, organised in five groups, was screened for their inhibitory activity of α-glucosidase, based on in vitro structure–activity relationship studies. Inhibitory kinetic analysis and molecular docking calculations were also applied for selected compounds. A flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group at C-ring, was the most active, presenting an IC50 much lower than the one found for the most widely prescribed α-glucosidase inhibitor, acarbose. The present work suggests that several of the studied flavonoids have the potential to be used as alternatives for the regulation of PPHG. 相似文献
923.
Arun K Mankan Marion Goldeck Klara Höning Moritz Gaidt Andrew V Kubarenko Liudmila Andreeva Karl‐Peter Hopfner Veit Hornung 《The EMBO journal》2014,33(24):2937-2946
Intracellular recognition of non‐self and also self‐nucleic acids can result in the initiation of potent pro‐inflammatory and antiviral cytokine responses. Most recently, cGAS was shown to be critical for the recognition of cytoplasmic dsDNA. Binding of dsDNA to cGAS results in the synthesis of cGAMP(2′–5′), which then binds to the endoplasmic reticulum resident protein STING. This initiates a signaling cascade that triggers the induction of an antiviral immune response. While most studies on intracellular nucleic acids have focused on dsRNA or dsDNA, it has remained unexplored whether cytosolic RNA:DNA hybrids are also sensed by the innate immune system. Studying synthetic RNA:DNA hybrids, we indeed observed a strong type I interferon response upon cytosolic delivery of this class of molecule. Studies in THP‐1 knockout cells revealed that the recognition of RNA:DNA hybrids is completely attributable to the cGAS–STING pathway. Moreover, in vitro studies showed that recombinant cGAS produced cGAMP upon RNA:DNA hybrid recognition. Altogether, our results introduce RNA:DNA hybrids as a novel class of intracellular PAMP molecules and describe an alternative cGAS ligand next to dsDNA. 相似文献
924.
925.
Eric T. Hoke I. T. Sachs‐Quintana Matthew T. Lloyd Isaac Kauvar William R. Mateker Alexandre M. Nardes Craig H. Peters Nikos Kopidakis Michael D. McGehee 《Liver Transplantation》2012,2(11):1351-1357
Understanding the stability and degradation mechanisms of organic solar materials is critically important to achieving long device lifetimes. Here, an investigation of the photodegradation of polymer:fullerene blend films exposed to ambient conditions for a variety of polymer and fullerene derivative combinations is presented. Despite the wide range in polymer stabilities to photodegradation, the rate of irreversible polymer photobleaching in blend films is found to consistently and dramatically increase with decreasing electron affinity of the fullerene derivative. Furthermore, blends containing fullerenes with the smallest electron affinities photobleached at a faster rate than films of the pure polymer. These observations can be explained by a mechanism where both the polymer and fullerene donate photogenerated electrons to diatomic oxygen to form the superoxide radical anion which degrades the polymer. 相似文献
926.
927.
Grazing-induced changes in plant composition affect litter quality and nutrient cycling in flooding Pampa grasslands 总被引:5,自引:0,他引:5
Changes in plant community composition induced by vertebrate grazers have been found to either accelerate or slow C and nutrient
cycling in soil. This variation may reflect the differential effects of grazing-promoted (G+) plant species on overall litter
quality and decomposition processes. Further, site conditions associated with prior grazing history are expected to influence
litter decay and nutrient turnover. We studied how grazing-induced changes in plant life forms and species identity modified
the quality of litter inputs to soil, decomposition rate and nutrient release in a flooding Pampa grassland, Argentina. Litter
from G+ forbs and grasses (two species each) and grazing-reduced (G−) grasses (two species) was incubated in long-term grazed
and ungrazed sites. G+ species, overall, showed higher rates of decomposition and N and P release from litter. However, this
pattern was primarily driven by the low-growing, high litter-quality forbs included among G+ species. Forbs decomposed and
released nutrients faster than either G+ or G− grasses. While no consistent differences between G+ and G− grasses were observed,
patterns of grass litter decay and nutrient release corresponded with interspecific differences in phenology and photosynthetic
pathway. Litter decomposition, N release and soil N availability were higher in the grazed site, irrespective of species litter
type. Our results contradict the notion that grazing, by reducing more palatable species and promoting less palatable ones,
should decrease nutrient cycling from litter. Plant tissue quality and palatability may not unequivocally link patterns of
grazing resistance and litter decomposability within a community, especially where grazing causes major shifts in life form
composition. Thus, plant functional groups defined by species’ “responses” to grazing may only partially overlap with functional
groups based on species “effects” on C and nutrient cycling. 相似文献
928.
Description of the digestive tract and feeding habits of the king angelfish and the Cortes angelfish 总被引:2,自引:0,他引:2
Morphologically, the digestive tracts of the king angelfish Holacunthus passer and the Cortes angelfish Pomacanthus zonipectus are similar, yet the king angelfish intestine is almost 30% longer than that of the Cortes angelfish. Both pomacanthids have a small mouth with villiform teeth, a short oesophagus, a well-defined stomach, and a terminal sac at the end of the digestive tract. The terminal sac, the acid pH in the stomach, and the long intestine may facilitate efficient use of seaweed nutrients. Stomach contents were analysed to determine diets and interspecific overlap. Seventy-one species were found in the stomachs of the king angelfish and 53 in the stomachs of the Cortes angelfish. Because of the wide range of species in their diets, both angelfish must be regarded as omnivorous. The most frequent foods were seaweed and sponges, but for the king angelfish, crustaceans were also important. A cluster analysis was done to determine whether the diets of these fish were similar by sex, size, or season. No similarities were found. Dietary overlap is high in relation to other pomacanthids. 相似文献
929.
ANDREW R. WHITELEY ANURADHA BHAT EMILIA P. MARTINS RICHARD L. MAYDEN M. ARUNACHALAM SILVA UUSI‐HEIKKILÄ A. T. A. AHMED JIWAN SHRESTHA MATTHEW CLARK DEREK STEMPLE LOUIS BERNATCHEZ 《Molecular ecology》2011,20(20):4259-4276
Understanding a wider range of genotype–phenotype associations can be achieved through ecological and evolutionary studies of traditional laboratory models. Here, we conducted the first large‐scale geographic analysis of genetic variation within and among wild zebrafish (Danio rerio) populations occurring in Nepal, India, and Bangladesh, and we genetically compared wild populations to several commonly used lab strains. We examined genetic variation at 1832 polymorphic EST‐based single nucleotide polymorphisms (SNPs) and the cytb mitochondrial gene in 13 wild populations and three lab strains. Natural populations were subdivided into three major mitochondrial DNA clades with an average among‐clade sequence divergence of 5.8%. SNPs revealed five major evolutionarily and genetically distinct groups with an overall FST of 0.170 (95% CI 0.105–0.254). These genetic groups corresponded to discrete geographic regions and appear to reflect isolation in refugia during past climate cycles. We detected 71 significantly divergent outlier loci (3.4%) and nine loci (0.5%) with significantly low FST values. Valleys of reduced heterozygosity, consistent with selective sweeps, surrounded six of the 71 outliers (8.5%). The lab strains formed two additional groups that were genetically distinct from all wild populations. An additional subset of outlier loci was consistent with domestication selection within lab strains. Substantial genetic variation that exists in zebrafish as a whole is missing from lab strains that we analysed. A combination of laboratory and field studies that incorporates genetic variation from divergent wild populations along with the wealth of molecular information available for this model organism provides an opportunity to advance our understanding of genetic influences on phenotypic variation for a vertebrate species. 相似文献
930.