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排序方式: 共有363条查询结果,搜索用时 15 毫秒
91.
Kevin M. Walton Richard DiRocco Becky A. Bartlett Elizabeth Koury Val Robert Marcy †Bruce Jarvis †Erik M. Schaefer Ratan V. Bhat 《Journal of neurochemistry》1998,70(4):1764-1767
Abstract: p38MAPK has been implicated in the regulation of proinflammatory cytokines and apoptosis in vitro. To understand its role in neurodegeneration, we determined the time course and localization of the dually phosphorylated active form of p38MAPK in hippocampus after global forebrain ischemia. Phosphorylated p38MAPK and mitogen-activated protein kinase-activated protein 2 activity increased over 4 days after ischemia. Phosphorylated p38MAPK immunoreactivity was observed in microglia in regions adjacent to, but not in, the dying CA1 neurons. In contrast, neither c-Jun N-terminal kinase 1 nor p42/p44MAPK activity was altered after ischemia. These results provide the first evidence for localization of activated p38MAPK in the CNS and support a role for p38MAPK in the microglial response to stress. 相似文献
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This pilot study considers space use and behavior patterns for nine chimpanzee mother-offspring pairs. Observations were conducted using instantaneous scan sampling, four times daily, five days a week, for four weeks. Mother-offspring use of vertical space and horizontal space and mother-offspring proximity were observed and analyzed using a Chi Square test. Results suggest mother-offspring pairs use levels above the enclosure floor, spending a majority of time in areas near horizontal bench substrates placed 1.2–2.5 m above the floor. Findings provide information that will assist managers in providing appropriate housing for chimpanzee (Pan troglodytes) mothers and their offspring. © 1994 Wiley-Liss, Inc. 相似文献
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The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization 总被引:8,自引:0,他引:8
Hess KC Jones BH Marquez B Chen Y Ord TS Kamenetsky M Miyamoto C Zippin JH Kopf GS Suarez SS Levin LR Williams CJ Buck J Moss SB 《Developmental cell》2005,9(2):249-259
Mammalian fertilization is dependent upon a series of bicarbonate-induced, cAMP-dependent processes sperm undergo as they "capacitate," i.e., acquire the ability to fertilize eggs. Male mice lacking the bicarbonate- and calcium-responsive soluble adenylyl cyclase (sAC), the predominant source of cAMP in male germ cells, are infertile, as the sperm are immotile. Membrane-permeable cAMP analogs are reported to rescue the motility defect, but we now show that these "rescued" null sperm were not hyperactive, displayed flagellar angulation, and remained unable to fertilize eggs in vitro. These deficits uncover a requirement for sAC during spermatogenesis and/or epididymal maturation and reveal limitations inherent in studying sAC function using knockout mice. To circumvent this restriction, we identified a specific sAC inhibitor that allowed temporal control over sAC activity. This inhibitor revealed that capacitation is defined by separable events: induction of protein tyrosine phosphorylation and motility are sAC dependent while acrosomal exocytosis is not dependent on sAC. 相似文献
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Becky Rynor 《CMAJ》2009,181(10):E227-E228
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Becky Rynor 《CMAJ》2010,182(3):E153-E154
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