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71.
N.S. Doherty P. Poubelle P. Borgeat T.H. Beaver G.L. Westrich N.L. Schrader 《Prostaglandins & other lipid mediators》1985,30(5):769-789
Intraperitoneal injection of zymosan in mice induced rapid extravasation and accumulation of plasma proteins in the peritoneal cavity. Neutrophils began to appear in the peritoneal cavity after a lag period of approximately 3 hours. The injected mice exhibited a pain response (writhing) during the first 30 minutes after injection, but writhing ceased before protein or cell accumulation had reached maximum levels. The injection of zymosan induced synthesis of PGE2 (measured by RIA) which reached maximum levels of 30 minutes, then declined slowly. Peptido-leukotriene levels (detected by bioassay, RIA and HPLC) increased rapidly after injection, reached a peak within an hour of injection and declined to undetectable levels within 4 hours. The early peptido-LT was predominantly LTC4, while later, LTE4 was the major component. LTD4 levels remained low throughout and no LTB4 was detected at any time. Indomethacin treatment elevated levels of peptido-LTs, recued PGE2 levels and inhibited writhing. Phenidone reduced peptido-LT levels. studies demonstrated that zymosan stimulates LTC4 synthesis by peritoneal cells whereas LTE4, LTD4, LTB4 or monoHETES were not detectable (using HPLC methods). The source of enzymes responsible for the metabolism of LTC4 to LTD4 and LTE4 could not be identified. 相似文献
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Clara Correia‐Melo Francisco DM Marques Rhys Anderson Graeme Hewitt Rachael Hewitt John Cole Bernadette M Carroll Satomi Miwa Jodie Birch Alina Merz Michael D Rushton Michelle Charles Diana Jurk Stephen WG Tait Rafal Czapiewski Laura Greaves Glyn Nelson Mohammad Bohlooly‐Y Sergio Rodriguez‐Cuenca Antonio Vidal‐Puig Derek Mann Gabriele Saretzki Giovanni Quarato Douglas R Green Peter D Adams Thomas von Zglinicki Viktor I Korolchuk João F Passos 《The EMBO journal》2016,35(7):724-742
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Janson J. White Juliana F. Mazzeu Zeynep Coban-Akdemir Yavuz Bayram Vahid Bahrambeigi Alexander Hoischen Bregje W.M. van Bon Alper Gezdirici Elif Yilmaz Gulec Francis Ramond Renaud Touraine Julien Thevenon Marwan Shinawi Erin Beaver Jennifer Heeley Julie Hoover-Fong Ceren D. Durmaz Halil Gurhan Karabulut Claudia M.B. Carvalho 《American journal of human genetics》2018,102(1):27-43
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Russell Grandbois Chris Yeager Yukinori Tani Chen Xu Saijin Zhang Morgan Beaver 《Geomicrobiology journal》2018,35(3):167-173
Radioactive 129I, a byproduct of nuclear power generation, can pose risks to human health if released into the environment, where its mobility is highly dependent on speciation. Based on thermodynamic principles, 129I should exist primarily as iodide (I?) in most terrestrial environments; however, organo-129I and 129iodate are also commonly detected in contaminated soils and groundwater. To investigate the capability of biogenic manganese oxides to influence iodide speciation, 17 manganese-oxidizing bacterial strains, representing six genera, were isolated from soils of the Savannah River Site, South Carolina. The isolates produced between 2.6 and 67.1 nmole Mn oxides (ml?1 media after 25 days, pH 6.5). Results from inhibitor assays targeting extracellular enzymes and reactive oxygen species indicated that both play a role in microbe-induced Mn(II) oxidation among the strains examined. Iodide oxidation was not observed in cultures of the most active Mn-oxidizing bacteria, Chryseobacterium sp. strain SRS1 and Chromobacterium sp. strain SRS8, or the fungus, Acremonium strictum strain KR21–2. While substantial amounts of Mn(III/IV) oxides were only generated in cultures at ≥pH 6, iodide oxidation was only observed in the presence of Mn(III/IV) oxides when the pH was ≤5. Iodide oxidation was promoted to a greater extent by synthetic Mn(IV)O2 than biogenic Mn(III/IV) oxides under these low pH conditions (≤pH 5). These results indicate that the influence of biogenic manganese oxides on iodide oxidation and immobilization is primarily limited to low pH environments. 相似文献
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Long-term trends in seasonal plankton dynamics in Lake Mead (Nevada-Arizona,USA) and implications for climate change 总被引:1,自引:0,他引:1
John R. Beaver Janet E. Kirsch Claudia E. Tausz Erin E. Samples Thomas R. Renicker Kyle C. Scotese Heidi A. McMaster Becky J. Blasius-Wert Paul V. Zimba Dale A. Casamatta 《Hydrobiologia》2018,817(1):85-96
Where biodiversity conservation and environmental preservation are significant concerns, rapid assessment and monitoring of the colonization and spread of non-native species are essential for timely decision-making and response. We developed and evaluated the adequacy of a rapid assessment protocol (RAP) for detecting non-native fish species in 74 Eastern Brazilian lakes. The RAP consists of a single field day employing two surveyors to conduct interviews with local sport fishers, visual surveys of fish, angling with lures, and gillnetting. We compared our results with those from separate, intense, large sampling effort (LSE) field surveys. Despite requiring less than 1/100th of the field effort, the RAP was able to detect the presence of most non-native fish species that were reported in the same lakes by LSE surveys. Information from local sport fishers was invaluable, particularly for detecting species that were in low abundance, but was not available for lakes within a forest preserve area. Non-native introductions commonly lead to rapid and widespread invasion and adverse effects on native biota. Our results strongly suggest that the RAP could function as a cost-effective tool for efficiently assessing the presence of non-native fishes in lakes and monitoring their colonization and spread over large geographic areas. 相似文献
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