全文获取类型
收费全文 | 774篇 |
免费 | 104篇 |
出版年
2022年 | 9篇 |
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 6篇 |
2018年 | 16篇 |
2017年 | 23篇 |
2016年 | 23篇 |
2015年 | 34篇 |
2014年 | 33篇 |
2013年 | 35篇 |
2012年 | 67篇 |
2011年 | 53篇 |
2010年 | 37篇 |
2009年 | 30篇 |
2008年 | 44篇 |
2007年 | 44篇 |
2006年 | 36篇 |
2005年 | 37篇 |
2004年 | 31篇 |
2003年 | 37篇 |
2002年 | 41篇 |
2001年 | 13篇 |
2000年 | 7篇 |
1999年 | 17篇 |
1998年 | 18篇 |
1997年 | 10篇 |
1996年 | 18篇 |
1995年 | 12篇 |
1994年 | 16篇 |
1993年 | 3篇 |
1992年 | 9篇 |
1991年 | 7篇 |
1990年 | 10篇 |
1989年 | 4篇 |
1987年 | 5篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1981年 | 14篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1973年 | 2篇 |
1971年 | 2篇 |
1969年 | 4篇 |
1967年 | 3篇 |
1966年 | 4篇 |
排序方式: 共有878条查询结果,搜索用时 15 毫秒
871.
872.
Charlène Insam Marie Méan Andreas Limacher Anne Angelillo-Scherrer Markus Aschwanden Martin Banyai Juerg- Hans Beer Henri Bounameaux Michael Egloff Beat Frauchiger Marc Husmann Nils Kucher Bernhard L?mmle Christian Matter Joseph Osterwalder Marc Righini Daniel Staub Nicolas Rodondi Drahomir Aujesky 《PloS one》2016,11(2)
Whether anticoagulation management practices are associated with improved outcomes in elderly patients with acute venous thromboembolism (VTE) is uncertain. Thus, we aimed to examine whether practices recommended by the American College of Chest Physicians guidelines are associated with outcomes in elderly patients with VTE. We studied 991 patients aged ≥65 years with acute VTE in a Swiss prospective multicenter cohort study and assessed the adherence to four management practices: parenteral anticoagulation ≥5 days, INR ≥2.0 for ≥24 hours before stopping parenteral anticoagulation, early start with vitamin K antagonists (VKA) ≤24 hours of VTE diagnosis, and the use of low-molecular-weight heparin (LMWH) or fondaparinux. The outcomes were all-cause mortality, VTE recurrence, and major bleeding at 6 months, and the length of hospital stay (LOS). We used Cox regression and lognormal survival models, adjusting for patient characteristics. Overall, 9% of patients died, 3% had VTE recurrence, and 7% major bleeding. Early start with VKA was associated with a lower risk of major bleeding (adjusted hazard ratio 0.37, 95% CI 0.20–0.71). Early start with VKA (adjusted time ratio [TR] 0.77, 95% CI 0.69–0.86) and use of LMWH/fondaparinux (adjusted TR 0.87, 95% CI 0.78–0.97) were associated with a shorter LOS. An INR ≥2.0 for ≥24 hours before stopping parenteral anticoagulants was associated with a longer LOS (adjusted TR 1.2, 95% CI 1.08–1.33). In elderly patients with VTE, the adherence to recommended anticoagulation management practices showed mixed results. In conclusion, only early start with VKA and use of parenteral LMWH/fondaparinux were associated with better outcomes. 相似文献
873.
874.
Dose‐response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current
下载免费PDF全文
![点击此处可从《Bioelectromagnetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Maraelys M. González Dasha F. Morales Luis E. B. Cabrales Daniel J. Pérez Juan I. Montijano Antonio R. S. Castañeda Victoriano G. S. González Oscar O. Posada Janet A. Martínez Arlem G. Delgado Karina G. Martínez Mayrel L. Mon Kalet L. Monzón Héctor M. C. Ciria Emilia O. Beatón Soraida C. A. Brooks Tamara R. González Manuel V. Jarque Miguel A. Ó. Mateus Jorge L. G. Rodríguez Enaide M. Calzado 《Bioelectromagnetics》2018,39(6):460-475
875.
Free radical-mediated oxidation of arachidonic acid to prostanoids has been implicated in a variety of pathophysiological conditions such as oxidative stress. Here, we report on the development of a liquid chromatography–mass spectrometry method to measure several classes of prostaglandin derivatives based on regioisomer-specific mass transitions down to levels of 20 pg/ml applied to the measurement of prostaglandin biomarkers in primary hepatocytes. The quantitative profiling of prostaglandin derivatives in rat and human hepatocytes revealed the increase of several isomers on stress response. In addition to the well-established markers for oxidative stress such as 8-iso-prostaglandin F2α and the prostaglandin isomers PE2 and PD2, this method revealed a significant increase of 15R-prostaglandin D2 from 236.1 ± 138.0 pg/1E6 cells in untreated rat hepatocytes to 2001 ± 577.1 pg/1E6 cells on treatment with ferric NTA (an Fe3+ chelate with nitrilotriacetic acid causing oxidative stress in vitro as well as in vivo). Like 15R-prostaglandin D2, an unassigned isomer that revealed a more significant increase than commonly analyzed prostaglandin derivatives was identified. Mass spectrometric detection on a high-resolution instrument enabled high-quality quantitative analysis of analytes in plasma levels from rat experiments, where increased concentrations up to 23-fold change treatment with Fe(III)NTA were observed. 相似文献
876.
877.
Antonio Rossi Hans J. van der Harten Frits A. Beemer Wim J. Kleijer Richard Gitzelmann Beat Steinmann A. Superti-Furga 《Human genetics》1996,98(6):657-661
Mutations in the diastrophic dysplasia sulfate transporter gene DTDST have been associated with a family of chondrodysplasias
that comprises, in order of increasing severity, diastrophic dysplasia (DTD), atelosteogenesis type 2 (AO2), and achondrogenesis
type 1B (ACG1B). To learn more about the molecular basis of DTDST chondrodysplasias and about genotype-phenotype correlations,
we studied fibroblast cultures of three new patients: one with AO-2, one with DTD, and one with an intermediate phenotype
(AO2/DTD). Reduced incorporation of inorganic sulfate into macromolecules was found in all three. Each of the three patients
was found to be heterozygous for a c862t transition predicting a R279W substitution in the third extracellular loop of DTDST.
In two patients (DTD and AO2/DTD), no other structural mutation was found, but polymerase chain reaction amplification and
single-strand conformation polymorphism analysis of fibroblast cDNA showed reduced mRNA levels of the wild-type DTDST allele:
these two patients may be compound heterozygotes for the “Finnish” mutation (as yet uncharacterized at the DNA level), which
causes reduced expression of DTDST. The third patient (with AO2) had the R279W mutation compounded with a novel mutation,
the deletion of cytosine 418 (Δc418), predicting a frameshift with premature termination. Also the Δc418 allele was underrepresented
in the cDNA, in accordance with previous observations that premature stop codons reduce mRNA levels. The presence of the DTDST
R279W mutation in a total of 11 patients with AO2 or DTD emphasizes the overlap between these conditions. This mutation has
not been found so far in 8 analyzed ACG1B patients, suggesting that it allows some residual activity of the sulfate transporter.
Received: 14 June 1996 / Revised: 8 August 1996 相似文献
878.
Yvonne Jackson William H. Dietz Charlene Sanders Lloyd J. Kolbe John J. Whyte Howell Wechsler Bruce S. Schneider Laura A. McNally Jean Charles-Azure Martina Vogel-Taylor Pamela Starke-Reed Van S. Hubbard Wendy L. Johnson-Taylor Ph.D. MPH R.D. Richard P. Troiano Karen Donato Susan Yanovski Robert J. Kuczmarski Lynne Haverkos Kathryn McMurry Randolph F. Wykoff Violet Woo Allan S. Noonan Jonelle Rowe Kathy McCarty Christine B. Spain 《Obesity (Silver Spring, Md.)》2002,10(12):1299-1305
Objective: To provide insight into discussions at the Surgeon General's Listening Session, “Toward a National Action Plan on Overweight and Obesity,” and to complement The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity. Research Methods and Procedures: On December 7 and 8, 2000, representatives from federal, state, academic, and private sectors attended the Surgeon General's Listening Session and were given an opportunity to recommend what to include in a national plan to address overweight and obesity. The public was invited to comment during a corresponding public comment period. The Surgeon General's Listening Session was also broadcast on the Internet, allowing others to view the deliberations live or access the archived files. Significant discussion points from the Listening Session have been reviewed by representatives of the federal agencies and are the basis of this complementary document. Results: Examples of issues, strategies, and barriers to change are discussed within five thematic areas: schools, health care, family and community, worksite, and media. Suggested cooperative or collaborative actions for preventing and decreasing overweight and obesity are described. An annotated list of some programmatic partnerships is included. Discussion: The Surgeon General's Listening Session provided an opportunity for representatives from family and community groups, schools, the media, the health-care environment, and worksites to become partners and to unite around the common goal of preventing and decreasing overweight and obesity. The combination of approaches from these perspectives offers a rich resource of opportunity to combat the public health epidemic of overweight and obesity. 相似文献