全文获取类型
收费全文 | 353篇 |
免费 | 41篇 |
出版年
2023年 | 8篇 |
2022年 | 6篇 |
2021年 | 15篇 |
2020年 | 14篇 |
2019年 | 10篇 |
2018年 | 11篇 |
2017年 | 12篇 |
2016年 | 17篇 |
2015年 | 25篇 |
2014年 | 24篇 |
2013年 | 21篇 |
2012年 | 24篇 |
2011年 | 28篇 |
2010年 | 19篇 |
2009年 | 18篇 |
2008年 | 16篇 |
2007年 | 18篇 |
2006年 | 10篇 |
2005年 | 17篇 |
2004年 | 12篇 |
2003年 | 5篇 |
2002年 | 10篇 |
2001年 | 5篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 3篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1974年 | 1篇 |
1970年 | 1篇 |
1962年 | 2篇 |
1961年 | 1篇 |
排序方式: 共有394条查询结果,搜索用时 0 毫秒
391.
Bastien Llamas Zhibin Jiang Marie-Line Rainville Sylvie Picard Christian F. Deschepper 《Mammalian genome》2005,16(9):700-711
Genetic mapping of the progeny of an F2 intercross between WKY and WKHA rats had previously allowed us to detect male-specific linkage between locus Cm24 and left ventricular mass index (LVMI). By further expanding that analysis, we detected additional loci that were all linked
to LVMI in a sex-specific manner despite their autosomal location. In males, we detected one additional locus (Lvm8) on Chromosome 5 (LOD = 3.4), the two loci Lvm13 (LOD = 4.5) and Lvm9 (LOD = 2.8) on Chromosome 17, and locus Lvm10 (LOD = 4.2) on Chromosome 12. The locus Lvm13 had the same boundaries as locus Cm26 previously reported by others using a different cross. None of these loci showed linkage to LVM in females. In contrast,
we identified in females the novel locus Lvm11 on Chromosome 15 (LOD = 2.8) and locus Lvm12 (LOD = 2.7) that had the same boundaries on Chromosome 3 as locus Cm25 detected previously by others using a cross of other normotensive strains. In prepubertal males, there were no differences
in the width of cardiomyocytes from WKY and WKHA rats, but cardiomyocytes from WKHA became progressively wider than that of
WKY as sexual maturation progressed. Altogether, these results provide evidence that distinct genes may influence LVMI of
rats in a sex-dependent manner, maybe by involving sex-specific interactions of sex steroids with particular genes involved
in the determination of LVMI and/or cardiomyocyte width. 相似文献
392.
Lyn-Marie Birkholtz Olivier Bastien Gordon Wells Delphine Grando Fourie Joubert Vinod Kasam Marc Zimmermann Philippe Ortet Nicolas Jacq Nadia Saïdani Sylvaine Roy Martin Hofmann-Apitius Vincent Breton Abraham I Louw Eric Maréchal 《Malaria journal》2006,5(1):1-24
The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data from Plasmodium falciparum, but using also the millions of genomic data from other species. Drug candidates are sought in a chemical space containing the millions of small molecules stored in public and private chemolibraries. Data management should, therefore, be as reliable and versatile as possible. In this context, five aspects of the organization and mining of malaria genomic and post-genomic data were examined: 1) the comparison of protein sequences including compositionally atypical malaria sequences, 2) the high throughput reconstruction of molecular phylogenies, 3) the representation of biological processes, particularly metabolic pathways, 4) the versatile methods to integrate genomic data, biological representations and functional profiling obtained from X-omic experiments after drug treatments and 5) the determination and prediction of protein structures and their molecular docking with drug candidate structures. Recent progress towards a grid-enabled chemogenomic knowledge space is discussed. 相似文献
393.
Background
Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic data. Two statistical models have been proposed. In the asymptotic limit of long sequences, the Karlin-Altschul model is based on the computation of a P-value, assuming that the number of high scoring matching regions above a threshold is Poisson distributed. Alternatively, the Lipman-Pearson model is based on the computation of a Z-value from a random score distribution obtained by a Monte-Carlo simulation. Z-values allow the deduction of an upper bound of the P-value (1/Z-value 2) following the TULIP theorem. Simulations of Z-value distribution is known to fit with a Gumbel law. This remarkable property was not demonstrated and had no obvious biological support. 相似文献394.
Johann Gout Roxane M. Pommier David F. Vincent Bastien Kaniewski Sylvie Martel Ulrich Valcourt Laurent Bartholin 《Journal of visualized experiments : JoVE》2013,(78)
This protocol permits rapid isolation (in less than 1 hr) of murine pancreatic acini, making it possible to maintain them in culture for more than one week. More than 20 x 106 acinar cells can be obtained from a single murine pancreas. This protocol offers the possibility to independently process as many as 10 pancreases in parallel. Because it preserves acinar architecture, this model is well suited for studying the physiology of the exocrine pancreas in vitro in contrast to cell lines established from pancreatic tumors, which display many genetic alterations resulting in partial or total loss of their acinar differentiation. 相似文献