Epidemiology of suicide pacts in England and Wales, 1988-92.

OBJECTIVE: To describe the epidemiology of suicide pacts in England and Wales DESIGN: Analysis of the death certificates and coroners'' records of all people who died in pacts between 1 January 1988 and 31 December 1992. SUBJECTS: 124 people who committed suicide in 62 pacts. RESULTS: Suicide in a pact accounted for 0.6% of all suicides (124/19721), a rate of 0.6 per million people aged 15 and over. Forty eight pacts were between married couples and five were between family members. The mean age was 56 years. 99 of the 124 subjects were of occupational social classes I-III. Poisoning by car exhaust fumes and drugs accounted for 116 deaths, with both members of each pair using the same method. CONCLUSIONS: Suicide pacts are rare and less common than they were 35 years ago, although the epidemiological profile is similar. People who commit suicide in a pact are more likely than those who commit suicide alone to be female, older, married, and of a high social class.     

Synthesis of basic fibroblast growth factor upon differentiation of rat mammary epithelial to myoepithelial-like cells in culture

Acidic fibroblast growth factor (aFGF) mRNA was detected in a rat mammary fibroblastic cell line, but not in rat mammary epithelial cell lines or myoepithelial-like cell lines. Basic FGF (bFGF) mRNA was detected in both the fibroblasts and the myoepithelial-like cells, but was absent from the epithelial cells. A series of cell lines representing stages in the differentiation pathway of epithelial cells to a myoepithelial-like morphology showed an increase in the amount of bFGF mRNA and activity present and the FGF from the myoepithelial-like rat mammary 29 cells was able to displace [125I]-bFGF specifically bound to rat mammary fibroblasts. FGF activity was also present in an extract of rat mammary gland. Analysis of cell extracts and conditioned medium indicated that FGF activity was cell-associated. The cell-associated bFGF was resistant to degradation by trypsin. Extraction of myoepithelial-like cells with Triton X-100 and 2 M NaCl showed that 50-65% of the cell-associated bFGF was in a detergent-resistant but 2 M NaCl-labile structure. Thus, the synthesis of bFGF is developmentally regulated in rat mammary cell lines, and at least 50% is present in the extracellular matrix.     

Neonatal castration of male and female rats affects luteinizing hormone responses to estrogen during adulthood

We examined the positive and negative feedback effects of estradiol (E2) on luteinizing hormone (LH) and prolactin (Prl) secretion in adult male and female rats which were gonadectomized within 24 h after birth (long-term castrates) and compared these responses to those elicited by E2 in short-term castrated (7 days) adult males and females. The high serum E2 did not reduce the elevated serum LH concentrations in long-term castrates until 4 days of treatment. Also, only after negative feedback was established were the positive feedback actions of E2 observed. In contrast, Prl surges were observed after 2 days of E2, and baseline Prl serum levels were elevated by Day 3 of E2 in long-term castrated male and female rats. Some long-term castrates lacked both LH and Prl surges, and E2 was ineffective in altering basal gonadotropin secretion in these animals. Short-term castrated males had elevated serum Prl levels but no Prl surges. Seemingly, when the hypothalamus is deprived of estrogen or androgen from birth to adulthood, an equal percentage of males and females become refractory to the positive feedback effects of estrogen during adulthood. Thus, it is difficult to separate castration effects from those which may be produced by the endogenous androgen secreted during the first 26 h of life.     

Relationships between management practices and ground‐active invertebrate biodiversity in New Zealand kiwifruit orchards

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The geographic scale of speciation in a marine snail with high dispersal potential

Aim We use the Stramonita haemastoma species complex (Muricidae) to investigate the geographic scale of speciation in a marine snail with a long pelagic larval duration (PLD) of 2–3 months and, consequently, high dispersal potential. We aim to: (1) delimit species within Stramonita, (2) discover the phylogenetic relationship among them, (3) map their distributions, and (4) infer the age and likely cause of speciation events. Location Tropical intertidal of the Atlantic and eastern Pacific Oceans. Methods We use one nuclear and two mitochondrial genes to construct a molecular phylogeny of the S. haemastoma species complex. We first test the monophyly of the genus and of the species complex, and then use statistical methods to delimit species within the complex. We incorporate information from museum collections and the literature to map distributions and to look for diagnostic morphological traits. We use fossils to date our phylogeny. Results The genus Stramonita is monophyletic and restricted to the tropical and warm‐temperate Atlantic and eastern Pacific oceans. The genus is composed of Stramonita delessertiana and six members of the S. haemastoma complex: S. haemastoma, Stramonita rustica, Stramonita floridana, Stramonita canaliculata, Stramonita biserialis and Stramonita brasiliensis (new species described herein). These species are supported by reciprocal monophyly in mitochondrial gene trees, together with independent evidence from morphology, distribution and the nuclear gene. The species are almost entirely allopatric, with only three instances of sympatry. Two species have unusually wide distributions, consistent with their long PLD; one of these is amphi‐Atlantic. Main conclusions Despite the long PLD of Stramonita, speciation has occurred within the Atlantic, both in response to barriers operating at the largest geographical scale (the width of Atlantic, but not the Amazon barrier) and at a smaller scale within the western Atlantic.     

Patterns of denitrification loss from grazed grassland: Effects of N fertilizer inputs at different sites

Factors influencing the seasonal and daily variation in denitrification rates in grazed swards were examined at 5 experimental sites in England with wide ranging environmental/geographic conditions. There was a wide range of fertilizer inputs at each site. Rates of denitrification were estimated by a coring and field incubation technique using acetylene to inhibit the reduction of N₂O to N₂. Major features of the detailed results from two of the sites were: (i) the large ranges in rates of loss, (ii) the relatively low contributions to total annual loss during autumn and winter, (iii) the apparent association of high rates of loss with fertilizer additions made when the soil was wet or immediately preceding a rainfall event, and (iv) significant losses from soil at 10–30 cm in the profile. Multiple quadratic regression analysis of the effects of soil NO₃ ^--N, soil temperature and water was used to explain variability in rates of loss. When separate regressions were fitted within each site × year × season × fertilizer level subset, 51% of the variation in loss was explained on a poorly drained fine loam/silt but only 38% on a freely drained loam.