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101.
Jinming Guan Leanne Barnard Jeanne Cresson Annabelle Hoegl Justin H. Chang Erick Strauss Karine Auclair 《Bioorganic & medicinal chemistry》2018,26(22):5896-5902
Pantothenate kinase (PanK) catalyzes the transformation of pantothenate to 4′-phosphopantothenate, the first committed step in coenzyme A biosynthesis. While numerous pantothenate antimetabolites and PanK inhibitors have been reported for bacterial type I and type II PanKs, only a few weak inhibitors are known for bacterial type III PanK enzymes. Here, a series of pantothenate analogues were synthesized using convenient synthetic methodology. The compounds were exploited as small organic probes to compare the ligand preferences of the three different types of bacterial PanK. Overall, several new inhibitors and substrates were identified for each type of PanK. 相似文献
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Brendon Howlin A.Rahim Mohd-Nor Jack Silver P.W.C. Barnard 《Inorganica chimica acta》1984,91(3):153-160
Titration data are reported for a number of substituted catechol molecules with ferric chloride. The data are interpreted in terms of the complexes formed and their stabilities. The pH's at which one complex transforms to another have been shown to have a linear relationship to modified Hammett substituent constants. It is demonstrated that this approach can be used to forecast approximate stabilities of complexes formed with iron, if the Hammett substituent constant of the ligand is known. 相似文献
104.
Phosphorus deficiency affects the anatomy of the unicellular green alga Scenedesmus obtusiusculus Chad. and influences the distribution of other inorganic elements in the cell in addition to phosphorus. Scenedesmus was grown under standard conditions with or without phosphorus. Cells were then cultured with phosphorus under conditions favouring glycolysis, respiration, or photophosphorylation for 2 h or photosynthesis for up to 8 h. The dominating features of phosphorus starvation, were loss of phosphorus and coions from polyphosphate bodies, accumulation of starch, decrease in the volume density of ribosomes both in the chloroplast and cytoplasm, and an increase in wall thickness. Under conditions favoring photosynthesis the mass fraction for phosphorus is low after 1 h, exceptionally high by 2 h, and diminishes by 8 h. High amounts of phosphorus are also regained under conditions favoring glycolysis and photophosphorylation but not respiration. After 2 h under photosynthetic conditions the volume densities of the chloroplast, cytoplasmic ribosomes, the vacuole, and the mitochondrion increased over controls. By 8 h the relative volume of the single ramified mitochondrion had decreased slightly and recognizable segments of it were sequestered within the vacuome. The autophagic nature of the vacuole was further evidenced by the presence of ribosomes and whorls of lamellae within it. Serial sections showed that all polyphosphate granules and sequestered materials were located within a continuous vacuolar cisterna. 相似文献
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Summary The effect of spray mixtures containing Zn, Mn, Cu, and B on the leaf levels of these elements in navel oranges was investigated in the Rustenburg area, South Africa.Foliar applications increased the levels of Zn, Mn, and B satisfactorily. The uptake of Mn appeared to be independent of complementary ions. Certain discrepancies observed in the uptake of other elements warrant further investigation. re]19720808 相似文献
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