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51.
Annette Lasham Erno Vreugdenhil Alan N. Bateson Eric A. Barnard Mark G. Darlison 《Journal of neurochemistry》1991,57(1):352-355
A series of genomic clones containing DNA that encodes the chicken gamma-aminobutyric acidA (GABAA) receptor beta 4 subunit have been isolated. These have been restriction mapped and partially sequenced to determine the structural organization and the size of the beta 4-subunit gene. This gene, which comprises nine exons, spans more than 65 kb. The organization of the chicken GABAA receptor beta 4-subunit gene has been compared to that of the murine GABAA receptor delta-subunit gene and to those of the genes that encode other members of the ligand-gated ion-channel superfamily, namely muscle and neuronal nicotinic acetylcholine receptors (AChRs). Although the positions of the intron/exon boundaries of GABAA receptor subunit genes are seen to be highly conserved, there are significant differences between the genes that encode GABAA receptor and AChR subunits. These results are discussed in relation to the proposal that this superfamily of ligand-gated ion-channel receptor genes arose by duplication of an ancestral receptor gene. 相似文献
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Comparison of the Molecular Forms of the Cholinesterases in Tissues of Normal and Dystrophic Chickens 总被引:3,自引:4,他引:3
Joan M. Lyles Israel Silman Luigi Di Giamberardino† Jean-Yves Couraud † Eric A. Barnard 《Journal of neurochemistry》1982,38(4):1007-1021
Abstract: The levels and molecular forms of acetylcholinesterase (AChE, EC 3.1.1.7) and pseudocholinesterase (ΦChE, EC 3.1.1.8) were examined in various skeletal muscles, cardiac muscles, and neural tissues from normal and dystrophic chickens. The relative amount of the heavy (Hc ) form of AChE in mixed-fibre-type twitch muscles varies in proportion to the percentage of glycolytic fast-twitch fibres. Conversely, muscles with higher levels of oxidative fibres (i.e., slow-tonic, oxidative-glycolytic fast-twitch, or oxidative slow-twitch) have higher proportions of the light (L) form of AChE. The effects of dystrophy on AChE and ΦChE are more severe in muscles richer in glycolytic fast-twitch fibres (e.g., pectoral or posterior latissimus dorsi, PLD); there is no alteration of AChE or ΦChE in a slow-tonic muscle. In the pectoral or PLD muscles from older dystrophic chickens, however, the AChE forms revert to a normal distribution while the ΦChE pattern remains abnormal. Muscle ΦChE is sensitive to collagenase in a similar way as is AChE, thus apparently having a similar tailed structure. Unlike skeletal muscle, cardiac muscle has very high levels of ΦChE, present mainly as the L form; AChE is present mainly as the medium (M) form, with smaller amounts of L and Hc . The latter pattern of AChE forms resembles that seen in several neural tissues examined. No alterations in AChE or ΦChE were found in cardiac or neural tissues from dystrophic chickens. 相似文献
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A high cell density transient transfection system for therapeutic protein expression based on a CHO GS‐knockout cell line: Process development and product quality assessment 下载免费PDF全文
56.
C. J. Barnard J. M. Behnke J. Sewell 《Ethology : formerly Zeitschrift fur Tierpsychologie》1996,102(1):63-84
Unrelated and previously unfamiliar male mice were maintained in groups of six tor different periods and at different ambient temperatures. High- and low-ranking males differed in hormone-related resistance to a subsequent experimental infection with the blood protozoan Babesia microti and there were rank differences in the apparent modulation of immunodepressive hormones relative to an individual's internal, social and physical environment. Resistance to B. microti was influenced by serum concentrations of corticosterone and testosterone. Associations between aggressiveness and measures of immunocompetence and resistance were related to corticosterone concentration, but only among low rankers. Effects of testosterone on resistance were confined to high rankers but were not associated with aggressiveness, although high rankers maintained greater aggressiveness than low rankers in all experimental treatments. The effects of group duration and temperature on resistance can be interpreted in terms of changing hormone and antibody levels in relation to metabolic stress. The results emphasize the importance of interactions between underlying physiological changes in relationships between behaviour, immune function and disease. 相似文献
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Ecnomus mennelli sp.n. from Lake Naivasha, Kenya, belongs to the natalensis‐group. E. thomasseti was also found at the lake, and these are the first records of Trichoptera from Naivasha. Adults and larvae of both species were collected, and an analysis of the gut contents of the larvae showed them to be mainly predator y on small invertebrates. The ecological requirements and distribution of the African species of Ecnomus are discussed. 相似文献
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This study was conducted to examine the psycho-emotional effects of repeated oral exposure to capsaicin, the principal active component of chili peppers. Each rat received 1 mL of 0.02% capsaicin into its oral cavity daily, and was subjected to behavioural tests following 10 daily administrations of capsaicin. Stereotypy counts and rostral grooming were significantly increased, and caudal grooming decreased, in capsaicin-treated rats during the ambulatory activity test. In elevated plus maze test, not only the time spent in open arms but also the percent arm entry into open arms was reduced in capsaicin-treated rats compared with control rats. In forced swim test, although swimming duration was decreased, struggling increased in the capsaicin group, immobility duration did not differ between the groups. Repeated oral capsaicin did not affect the basal levels of plasma corticosterone; however, the stress-induced elevation of plasma corticosterone was prolonged in capsaicin treated rats. Oral capsaicin exposure significantly increased c-Fos expression not only in the nucleus tractus of solitarius but also in the paraventricular nucleus. Results suggest that repeated oral exposure to capsaicin increases anxiety-like behaviours in rats, and dysfunction of the hypothalamic-pituitary-adrenal axis may play a role in its pathophysiology. 相似文献
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