Fish and fisheries of the tidal Thames: management of the modern resource, research aims and future pressures

In recent decades, following the cleanup in the 1960s, the Thames Estuary has become a major nursery ground for economic and conservation species, and has seen the development of substantial commercial and recreational fisheries. The Environment Agency has both sea fisheries and freshwater fisheries statutory powers in the estuary. A unique and focussed survey programme has been developed to inform management policies. A Fisheries Management Action Plan has been developed to promote integrated salmonid, eel Anguilla anguilla and sea fisheries management, promote nurseries, sustainable exploitation and habitat protection and enhancement. Data are used to influence water quality, water resources and flood defence management regimes and in the planning field to influence development proposals. Consensus and collaboration have been built through the Thames Estuary Partnership. Research aims identified through the Thames Estuary Research Forum are described together with future pressures on key species. The survey rationales being developed will contribute to new standard sampling strategies and classification scheme to meet the requirements of the E.U. Water Framework Directive.     

EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics

Regulation of mRNA stability and translation plays a critical role in determining protein abundance within cells. Processing bodies (P‐bodies) are critical regulators of these processes. Here, we report that the Pim1 and 3 protein kinases bind to the P‐body protein enhancer of mRNA decapping 3 (EDC3) and phosphorylate EDC3 on serine (S)161, thereby modifying P‐body assembly. EDC3 phosphorylation is highly elevated in many tumor types, is reduced upon treatment of cells with kinase inhibitors, and blocks the localization of EDC3 to P‐bodies. Prostate cancer cells harboring an EDC3 S161A mutation show markedly decreased growth, migration, and invasion in tissue culture and in xenograft models. Consistent with these phenotypic changes, the expression of integrin β1 and α6 mRNA and protein is reduced in these mutated cells. These results demonstrate that EDC3 phosphorylation regulates multiple cancer‐relevant functions and suggest that modulation of P‐body activity may represent a new paradigm for cancer treatment.