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51.
52.
Simon M.N. Efange Yung-Chi Cheng Thomas J. Bardos 《Nucleosides, nucleotides & nucleic acids》2013,32(5):545-564
Abstract The syntheses of 5-ethynyl-, 5-phenylethynyl- and 5-propynyl-2(1H)-pyrimidinone 2′-deoxyribosides are described. Two of the new nucleosides, 14 a and 14 c, showed significant antiviral activities against HSV-1 and HSV-2 in tissue culture. 相似文献
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54.
Horváth A Beck Z Bardos TJ Dunn JA Aradi J 《Bioorganic & medicinal chemistry letters》2006,16(20):5321-5323
Suligovir is a 35-mer homo-oligonucleotide, containing exclusively 4-thio deoxyuridylate, proved to be a potent inhibitor of HIV entry. In this paper, we described the effect of extent of thiolation and the introduction of nuclease-resistant phosphorothioate linkages on the anti-HIV activity of Suligovir. We found that the decreased thiolated nucleotide content decreases the anti-HIV potency of the compound and the introduction of phosphorothioate linkages does not improve its antiviral activity. 相似文献
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56.
Bardos T Czipri M Vermes C Finnegan A Mikecz K Zhang J 《Arthritis research & therapy》2003,5(2):R106-R113
Accumulating evidence suggests that regulatory T cells play a crucial role in preventing autoimmunity. Recently, a naturally
occurring CD4+CD25+ T-cell subset that is anergic and also suppressive has been shown to suppress autoimmunity in several animal models. We used
proteoglycan-induced arthritis (PGIA) as a study model to investigate the role of the CD4+CD25+ regulatory T cells in autoimmune arthritis. There was no significant change in the percentage of CD4+CD25+ T cells during the immunization period when proteoglycan- or ovalbumin-immunized BALB/c and C57BL/6 mice were compared. An
adoptive transfer study showed that the CD4+CD25+ T cells did not protect severe combined immunodeficient mice from arthritis when they were cotransferred with splenocytes
from arthritic animals. Similarly, depletion of the CD4+CD25+ T cells did not enhance the onset of the disease or disease severity in severe combined immunodeficient mice. Moreover, CD28-deficient
mice, which have very few CD4+CD25+ T cells, were highly resistant to PGIA. These findings indicate that the CD4+CD25+ regulatory T cells may not play a critical role in controlling PGIA. 相似文献
57.
Bardos DC 《Bulletin of mathematical biology》2005,67(3):529-545
Characterizing organism growth within populations requires the application of well-studied individual size-at-age models,
such as the deterministic Gompertz model, to populations of individuals whose characteristics, corresponding to model parameters,
may be highly variable. A natural approach is to assign probability distributions to one or more model parameters. In some
contexts, size-at-age data may be absent due to difficulties in ageing individuals, but size-increment data may instead be
available (e.g., from tag-recapture experiments). A preliminary transformation to a size-increment model is then required.
Gompertz models developed along the above lines have recently been applied to strongly heterogeneous abalone tag-recapture
data. Although useful in modelling the early growth stages, these models yield size-increment distributions that allow negative
growth, which is inappropriate in the case of mollusc shells and other accumulated biological structures (e.g., vertebrae)
where growth is irreversible.
Here we develop probabilistic Gompertz models where this difficulty is resolved by conditioning parameter distributions on
size, allowing application to irreversible growth data. In the case of abalone growth, introduction of a growth-limiting biological
length scale is then shown to yield realistic length-increment distributions. 相似文献
58.
5'Mercaptouridine-5'-diphosphate (hs5UDP) has been synthesized and investigated as a substrate of the polynucleotide phosphorylase of Micrococcus luteus. While hs5UDP is not utilized alone, it can be copolymerized with UDP; however, unusually for this enzyme, the ratio of 5'mercaptouridylate vs. uridylate residues in the polynucleotide product (MPU) is always lower than the ratio of hs5UDP v. UDP in the substrate mixture. Furthermore, hs5UDP decreases the rate of the enzymic polymerization reaction. The MPU product forms two-stranded and three-stranded complexes with poly(A). The circular dichroic spectra of these complexes are similar to those formed between poly(U) and poly(A), but their melting profiles indicate somewhat lower stability. The physicochemical and biochemical properties of the enzymic product are qualitatively similar to those of MPU prepared by chemical modification; both are potent inhibitors of a DNA-dependent RNA polymerase. 相似文献
59.
Although unmodified poly C and unmodified ribosomal RNA showed little ( < 20%) or no inhibition of 6–7S cytoplasmic, 3–4S cytoplasmic and 3–4S chromatin-associated DNA-directed DNA polymerases and of RNase sensitive endogenous DNA polymerase and DNA-directed DNA polymerase activity associated with a particulate material (p = 1.16 ? 1.18 g/ml) from Burkitt cells the thiolated poly C and thiolated RNA were strongly inhibitory (70–97%). Moreover, the thiolated nucleic acids were more inhibitory to 6–7S enzyme than to 3–4S enzyme. Thiolation of nucleic acids thus appears to be a potentially important procedure for the development of agents which may be selective against certain polymerases. 相似文献
60.
W Troll S Belman E Berkowitz Z F Chmielewicz J L Ambrus T J Bardos 《Biochimica et biophysica acta》1968,157(1):16-24