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21.
Suppression of bacterial cell wall-induced polyarthritis by recombinant gamma interferon 总被引:1,自引:0,他引:1
Group A streptococcal cell wall fragments (SCW) induce erosive polyarthritis, characterized by synovial cell hyperplasia and intense mononuclear cell infiltration, in susceptible rats. Because of the known antiproliferative and immunomodulatory effects of interferon (IFN), we evaluated the effect of systemically administered alpha, beta and gamma IFN on the evolution of these destructive lesions. Treatment with gamma IFN not only reduced the acute response, but had an even greater suppressive effect on the chronic mononuclear cell-mediated destructive phase of the disease (articular index 10.2 +/- 1.2 for SCW only versus 3.8 +/- 0.7 for SCW + gamma IFN; p less than 0.01). Treatment with gamma IFN was more effective in the suppression of the arthritis than alpha, beta IFN. Histopathologic evaluation of the joints demonstrated that gamma IFN-treated animals had significantly fewer inflammatory cells, and less synovial hyperplasia and erosions than the SCW controls. gamma IFN suppression of mononuclear cell prostaglandin synthesis and synovial fibroblast proliferation was consistent with its anti-arthritic effects. These data indicate that the pathophysiology of SCW-induced erosive polyarthritis is subject to regulatory control by gamma IFN and that the mechanisms of suppression may be relevant in the treatment of rheumatoid arthritis. 相似文献
22.
Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents 总被引:10,自引:0,他引:10
Glucocorticoids can mediate the destruction of thymocytes and T cell-derived leukemia cells through a mechanism known as apoptosis. The characteristic feature of apoptosis is fragmentation of DNA at internucleosomal linkers through the activity of a specific endonuclease. In this study, an attempt was made to compare dexamethasone-induced apoptosis in two T cell-derived human leukemia lines (CEM-C1 and CEM-C7) to the cell killing brought about by selected cytotoxic agents. In the CEM-C7 cell line (dexamethasone-sensitive), apoptosis was induced not only by dexamethasone but by actinomycin D, cycloheximide, and 25-OH cholesterol. In the CEM-C1 cell line (dexamethasone-resistant) cycloheximide, 25-OH cholesterol, or cell starvation could induce apoptosis. It appears that in leukemic cells apoptosis may be induced by a variety of unrelated toxic agents and is not limited to glucocorticoids. 相似文献
23.
Goutam Gupta Manju Bansal V. Sasisekharan 《Biochemical and biophysical research communications》1980,95(2):728-733
A novel zig-zag (Z) structure is proposed for poly d(GC).poly d(GC). The proposed model closely resembles the crystal structure of d(CG)3. 相似文献
24.
A simple procedure for the isolation of cathepsin-B from bovine pancreas employing ammonium sulphate fractionation, DEAE cellulose
chromatography and Sephadex G-200 gel filtration is described. The purified enzyme gave a single band on polyacrylamide gel
electrophoresis. The molecular weight as determined by gel filtration of the enzyme was 26,850. ItsK
m andV
max values were 12.8 mM and 0.303 Μmol/min/mg, respectively. TheK
i for iodoacetamide was 0.16 mM. 相似文献
25.
Bansal Mitaly Adamski Nikolai M. Toor Puneet Inder Kaur Satinder Sharma Achla Srivastava Puja Bansal Urmil Uauy Cristobal Chhuneja Parveen 《Molecular biology reports》2021,48(6):5209-5216
Molecular Biology Reports - Stripe rust and leaf rust are among the most devastating diseases of wheat, limiting its production globally. Wheat wild relatives harbour genetic diversity for new... 相似文献
26.
Bansal Kanika Kaur Amandeep Midha Samriti Kumar Sanjeet Korpole Suresh Patil Prabhu B. 《Antonie van Leeuwenhoek》2021,114(11):1935-1947
Antonie van Leeuwenhoek - We report three yellow-pigmented, Gram-negative, aerobic, rod-shaped, motile bacterial isolates designated as PPL1T, PPL2, and PPL3 from healthy basmati rice seeds.... 相似文献
27.
28.
Arvinder Toor Urmil Bansal Harbans Bariana 《Molecular breeding : new strategies in plant improvement》2013,32(3):699-707
Flag smut, caused by Urocystis agropyri, has been a problem in wheat production, but its incidence has declined with the use of resistant varieties and seed dressing. Diamondbird, an Australian wheat cultivar that carries high levels of resistance to flag smut, was crossed with susceptible Chinese landrace TH3929 and a doubled haploid (DH) population was developed. A linkage map comprising 386 markers was used for detection of genomic regions controlling flag smut resistance. Composite interval mapping identified five quantitative trait loci (QTL) with significant effects for flag smut resistance. QTL QFs.sun-3AL, QFs.sun-6AS, QFs.sun-1BL and QFs.sun-5BS were contributed by Diamondbird. Although TH3929 was susceptible, it contributed a minor QTL QFs.sun-3AS. QTL QFs.sun-3AL and QFs.sun-6AS were detected in both seasons and each explained more than 17 % of the variation in flag smut response. Other QTL QFs.sun-3AS, QFs.sun-1BL and QFs.sun-5BS explained 5–10 % of the phenotypic variation. DH lines that showed low flag smut levels carried combinations of three or more QTL. This is the first report on chromosomal location of flag smut resistance in a modern common wheat cultivar. 相似文献
29.
Zarifi Masri Arvydas Ruseckas Evguenia V. Emelianova Linjun Wang Ashu K. Bansal Andrew Matheson Henrik T. Lemke Martin M. Nielsen Ha Nguyen Olivier Coulembier Philippe Dubois David Beljonne Ifor D. W. Samuel 《Liver Transplantation》2013,3(11):1445-1453
A joint experimental and theoretical study of singlet exciton diffusion in spin‐coated poly(3‐hexylthiophene) (P3HT) films and its dependence on molecular weight is presented. The results show that exciton diffusion is fast along the co‐facial π–π aggregates of polymer chromophores and about 100 times slower in the lateral direction between aggregates. Exciton hopping between aggregates is found to show a subtle dependence on interchain coupling, aggregate size, and Boltzmann statistics. Additionally, a clear correlation is observed between the effective exciton diffusion coefficient, the degree of aggregation of chromophores, and exciton delocalization along the polymer chain, which suggests that exciton diffusion length can be enhanced by tailored synthesis and processing conditions. 相似文献
30.