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Debra L Fulton Yvonne Y Li Matthew R Laird Benjamin GS Horsman Fiona M Roche Fiona SL Brinkman 《BMC bioinformatics》2006,7(1):270-16
Background
Orthologs (genes that have diverged after a speciation event) tend to have similar function, and so their prediction has become an important component of comparative genomics and genome annotation. The gold standard phylogenetic analysis approach of comparing available organismal phylogeny to gene phylogeny is not easily automated for genome-wide analysis; therefore, ortholog prediction for large genome-scale datasets is typically performed using a reciprocal-best-BLAST-hits (RBH) approach. One problem with RBH is that it will incorrectly predict a paralog as an ortholog when incomplete genome sequences or gene loss is involved. In addition, there is an increasing interest in identifying orthologs most likely to have retained similar function. 相似文献32.
Prof. Dr. Christchellyn Klegin Prof. Dr. Eduardo Miranda Ethur Prof. Dr. Juçara Bordin Prof. Dr. Pablo Luis Baia Figueiredo 《化学与生物多样性》2023,20(10):e202300286
This study aimed to report the unprecedented volatile composition of the mosses Phyllogonium viride BRID, Orthotichella rigida (MÜLL.HAL.) B. H. ALLEN & MAGILL and Schlotheimia rugifolia (HOOK.) SCHWÄGR occurring in the Brazilian Atlantic Forest, in order to elucidate the chemical composition of these species and enrich the chemotaxonomic knowledge of mosses. 28 compounds were identified, the major constituent being hexadecanoic acid, also known as palmitic acid, specifically P. viride com (38.55 %), O. rigida com (17.17 %) and S. rugifolia com (24.94 %), followed by phytol, P. viride com (3.92 %), O. rigida com (28.57 %) and S. rugifolia com (36.13 %). In addition, there was a prevalence of aliphatic hydrocarbons (25 %) and fatty acids (17.8 %) in the evaluated samples. These data contribute to the generation of new scientific information about the chemical constitution of mosses, still little studied, enriching the chemotaxonomic collection of the taxon. 相似文献
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Evolution of antibiotic resistance genes: the DNA sequence of a kanamycin resistance gene from Staphylococcus aureus 总被引:14,自引:0,他引:14
The kanamycin resistance gene from Staphylococcus aureus has been sequenced
and its structure compared with similar genes isolated from Streptomyces
fradiae and from two transposons, Tn5 and Tn903, originally isolated from
Klebsiella pneumoniae and Salmonella typhimurium, respectively. The genes
are all homologous but, since their common ancestor, have undergone
extensive divergence, with more than 43% divergence between the closest
pair. The phylogeny of the genes cannot be made congruent to the phylogeny
of the taxa from which they were isolated without requiring rather
improbable differences in rates. One is therefore led to conclude that
there have been multiple occurrences of gene transfer between these
species. Thus, although they are homologous, they are neither orthologous
nor paralogous. It is suggested that homologous genes of this type be
called xenologous.
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