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91.
Liu Xinrong Liu Shuya Tang Yong Pu Zhengjia Xiao Hong Gao Jieying Yin Qi Jia Yan Bai Qunhua 《Neurochemical research》2021,46(6):1514-1539
Neurochemical Research - Gut microbial dysbiosis and alteration of gut microbiota composition in Parkinson's disease (PD) have been increasingly reported, no recognized therapies are available... 相似文献
92.
Chen Yen-Chi Wang I-Jen Cheng Chih-Ching Wu Yu-Chiao Bai Chun-Hsuan Yu Kuo-Pin 《Aerobiologia》2021,37(2):243-252
Aerobiologia - The liquid impingers can be used for sampling of viral aerosols, such as COVID-19 virus, influenza, and measles. However, the lowest cutoff diameter of commercially available liquid... 相似文献
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Chen Zhang Qisheng Zuo Man Wang Hao Chen Nana He Jing Jin Tingting Li Jingyi Jiang Xia Yuan Jiancheng Li Xiang Shi Ming Zhang Hao Bai Yang Zhang Qi Xu Hengmi Cui Guobin Chang Jiuzhou Song Hongyan Sun Yani Zhang Guohong Chen Bichun Li 《Journal of cellular physiology》2021,236(2):1391-1400
The development of primordial germ cells (PGCs) undergoes epigenetic modifications. The study of histone methylation in regulating PGCs is beneficial to understand the development and differentiation mechanism of germ stem cells. Notably, it provides a theoretical basis for directed induction and mass acquisition in vitro. However, little is known about the regulation of PGC formation by histone methylation. Here, we found the high enrichment of H3K4me2 in the blastoderm, genital ridges, and testis. Chromatin immunoprecipitation sequencing was performed and the results revealed that genomic H3K4me2 is dynamic in embryonic stem cells, PGCs, and spermatogonial stem cells. This trend was consistent with the H3K4me2 enrichment in the gene promoter region. Additionally, narrow region triggered PGC‐related genes (Bmp4, Wnt5a, and Tcf7l2) and signaling pathways (Wnt and transforming growth factor‐β). After knocking down histone methylase Mll2 in vitro and vivo, the level of H3K4me2 decreased, inhibiting Cvh and Blimp1 expression, then repressing the formation of PGCs. Taken together, our study revealed the whole genome map of H3K4me2 in the formation of PGCs, contributing to improve the epigenetic study in PGC formation and providing materials for bird gene editing and rescue of endangered birds. 相似文献
98.
为了研究海蜇-对虾(中国明对虾、斑节对虾)-菲律宾蛤仔海水综合养殖池塘养殖生物的食性、营养级和池塘食物网结构,在2017年5—9月的养殖周期内,采集并检测池塘内各种饵料和4种养殖生物的碳、氮稳定同位素比值(δ13C、δ15N),并运用IsoSource线性混合模型分析了海蜇、中国明对虾、斑节对虾和菲律宾蛤仔的食物来源。结果表明: 海蜇的主要食物来源为浮游动物;中国明对虾和斑节对虾的主要食物来源为投喂的鯷鱼;菲律宾蛤仔的主要食物来源为浮游植物、底栖硅藻和对虾粪便。综合养殖池塘中菲律宾蛤仔的营养级范围为2.64~2.95,平均值为2.84;海蜇的营养级范围为2.78~3.27,平均值为3.06;斑节对虾的营养级范围为3.03~3.54,平均值为3.25;中国明对虾的营养级范围为3.76~4.40,平均值为3.95。在综合养殖池塘中,菲律宾蛤仔为初级消费者,海蜇为次级消费者,中国明对虾和斑节对虾为捕食者;菲律宾蛤仔在滤食两种对虾粪便的同时一定程度上改善了养殖池塘的水质。 相似文献
99.
Zhu Yun Xu Baoping Li Changchong Chen Zhimin Cao Ling Fu Zhou Shang Yunxiao Chen Aihuan Deng Li Bao Yixiao Sun Yun Ning Limin Yu Shuilian Gu Fang Liu Chunyan Yin Ju Shen Adong Xie Zhengde Shen Kunling 《中国病毒学》2021,36(6):1543-1553
Virologica Sinica - Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality in children worldwide. In this study, we aimed to describe the aetiology of viral... 相似文献
100.
Zhijie Ren Fenglin Bai Jingwen Xu Li Wang Xiaohan Wang Qian Zhang Changxin Feng Qi Niu Liying Zhang Jiali Song Fang Bao Liangyu Liu Yikun He Ligeng Ma Wang Tian Congcong Hou Legong Li 《植物学报(英文版)》2021,63(12):2150-2150
Grain size is determined by the size and number of cells in the grain. The regulation of grain size is crucial for improving crop yield; however, the genes and molecular mechanisms that control grain size remain elusive. Here, we report that a member of the detoxification efflux carrier /Multidrug and Toxic Compound Extrusion (DTX/MATE) family transporters, BIG RICE GRAIN 1 (BIRG1), negatively influences grain size in rice (Oryza sativa L.). BIRG1 is highly expressed in reproductive organs and roots. In birg1 grain, the outer parenchyma layer cells of spikelet hulls are larger than in wild-type (WT) grains, but the cell number is unaltered. When expressed in Xenopus laevis oocytes, BIRG1 exhibits chloride efflux activity. Consistent with this role of BIRG1, the birg1 mutant shows reduced tolerance to salt stress at a toxic chloride level. Moreover, grains from birg1 plants contain a higher level of chloride than those of WT plants when grown under normal paddy field conditions, and the roots of birg1 accumulate more chloride than those of WT under saline conditions. Collectively, the data suggest that BIRG1 in rice functions as a chloride efflux transporter that is involved in mediating grain size and salt tolerance by controlling chloride homeostasis. 相似文献