全文获取类型
收费全文 | 622篇 |
免费 | 43篇 |
国内免费 | 1篇 |
出版年
2023年 | 7篇 |
2022年 | 27篇 |
2021年 | 38篇 |
2020年 | 51篇 |
2019年 | 74篇 |
2018年 | 51篇 |
2017年 | 25篇 |
2016年 | 26篇 |
2015年 | 33篇 |
2014年 | 27篇 |
2013年 | 48篇 |
2012年 | 55篇 |
2011年 | 33篇 |
2010年 | 17篇 |
2009年 | 18篇 |
2008年 | 18篇 |
2007年 | 35篇 |
2006年 | 12篇 |
2005年 | 20篇 |
2004年 | 12篇 |
2003年 | 9篇 |
2002年 | 4篇 |
2001年 | 9篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1984年 | 1篇 |
排序方式: 共有666条查询结果,搜索用时 15 毫秒
41.
Soroush M. Z. Maghooli K. Pisheh N. F. Mohammadi M. Soroush P. Z. Tahvilian P. 《Neurophysiology》2019,51(3):180-190
Neurophysiology - A novel method based on EEG nonlinear analysis and analysis of steady-state visual evoked potentials (SSVEPs) has been processed. The EEG phase space is reconstructed, and some... 相似文献
42.
Zohreh Poursina Asadollah Mohammadi Shadi Zamanian Yazdi Ian Humpson Veda Vakili Reza Boostani Houshang Rafatpanah 《Journal of cellular biochemistry》2019,120(9):15740-15745
Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) disease is a chronic neuroinflammatory disease, which is associated with HTLV-1 infection. There is no effective and satisfactory treatment of HAM/TSP. It has been shown that curcumin exhibits modulatory effects on apoptosis and cytotoxicity-related molecules in HAM/TSP patients. In the present study, we examined the effect of curcumin on the gene expression of caspase-8, caspase-10, and anti-apoptotic protein c-FLIP, in HAM/TSP patients. Furthermore, we compared the expression of these molecules between HAM/TSP and asymptomatic carriers. Real-time PCR was performed to examine the mRNA expression of caspase-8, caspase-10, and c-FLIP in studied groups. The mRNA expression of caspase-8 and caspase-10 was similar before and after curcumin treatment in HAM/TSP patients (P > 0.05). The mRNA expression of c-FLIPL and c-FLIPs was higher after curcumin treatment compared with before treatment and significant differences were observed between the two groups (P = 0.004 and P = 0.044, respectively). The mRNA expression levels of caspase-8, caspase-10, c-FLIPL, and c-FLIPs were not statistically significant between HAM/TSP patients and asymptomatic carriers (P < 0.05). In conclusion, our results showed that curcumin increased the expression of c-FLIP in HAM/TSP patients which might suggest that, this molecule is involved in the apoptosis of HTLV-1-infected cells. Further studies with large sample size could be useful to clarify the role of this supplement in HAM/TSP patients. 相似文献
43.
Najmeh Jaberi Atena Soleimani Mehran Pashirzad Hosein Abdeahad Fariba Mohammadi Mahdieh Khoshakhlagh Majid Khazaei Gordon A Ferns Amir Avan Seyed Mahdi Hassanian 《Journal of cellular biochemistry》2019,120(4):4757-4765
Atherosclerosis is an arterial disease associated with inflammation. Thrombin is a procoagulant and proinflammatory serine protease that contributes to the pathology of atherosclerosis by enhancing the expression of cell adhesion molecules, inducing the secretion of proinflammatory cytokines, activating inflammatory responses in atherosclerotic plaques, stimulating proliferation of aortic smooth muscle cells, and exacerbating vascular lesions at sites of injury. Hence, thrombin appears to be an important target for treatment of atherosclerosis and thrombin pharmacological inhibitors have significant therapeutic potency for suppressing inflammatory responses in cardiovascular diseases. This review summarizes the proinflammatory signaling functions of thrombin as well as the therapeutic potency of thrombin inhibitors in the pathogenesis of atherosclerosis and hence their potential therapeutic value in this condition. 相似文献
44.
45.
46.
Protein and metabolic engineering would greatly benefit from a general system linking the presence of a small molecule to the power of genetic selection. We use nuclear receptors to link the survival of Saccharomyces cerevisiae to the presence of small molecules through genetic selection, extending classical genetic complementation to a new "chemical complementation." In this system the Gal4 DNA-binding domain is fused to ligand-binding domains from two nuclear receptors, expressed in the strain PJ69-4A, and grown on plates containing known ligands for the receptors. Yeast survive on selective plates only in the presence of a nuclear receptor and the corresponding ligand. Mutagenesis can increase the sensitivity of chemical complementation. This system may be extended to engineer nuclear receptors for practically any small molecule through directed evolution coupled to genetic selection, and for performing metabolic engineering in yeast. 相似文献
47.
Twenty Tolypothrix strains, including 15 strains of T. tenuis, three strains of T. ceylonica and one strain each of T. nodosa and T. bouteillei, were evaluated for their phycobiliprotein content and composition. Significant differences among the Tolypothrix strains were found at both inter- and intra-specific levels in the production of phycobiliprotein constituents--phycocyanin (PC), allophycocyanin (APC) and phycoerythrin (PE). Four specific parameters, viz. PC or PE content, total phycobiliprotein and total protein content, and percentage of phycobiliproteins, in a mixture of total proteins were used to select four T. tenuis and one T. ceylonica strain as useful for phycobiliproteins production. 相似文献
48.
49.
50.
Bahareh Eftekharzadeh Javad Hamedi Fatemeh Mohammadipanah Fariba Khodagholi Nader Maghsoudi Hans Peter Klenk 《Applied microbiology and biotechnology》2010,86(6):1805-1811
Actinomycetes isolated from Iran soil habitats were tested for the capacity to produce compounds which can protect neurons
from cell death generated by oxidative stress in NT2 neurons. Confirmation of our initial hit was accomplished via the determination
of amyloid β level using the enzyme-linked immunosorbent assay test. The most interesting amyloid β formation inhibitor discovered
in our study was a secondary metabolite which was produced by strain HM45. This bioactive strain was identified as a strain
of Streptomyces antibioticus DSM 40234 using polyphasic approach. The strain HM45 was deposited in Deutsche Sammlung von Mikroorganismen und Zellkulturen
as S. antibioticus DSM 41955 and University of Tehran Microorganisms Sollection as S. antibioticus UTMC 00105. This work is the first report on efficiency of an actinomycete metabolite in prohibition of neurons death caused
by amyloid β formation. 相似文献