全文获取类型
收费全文 | 388篇 |
免费 | 30篇 |
专业分类
418篇 |
出版年
2023年 | 2篇 |
2022年 | 8篇 |
2021年 | 12篇 |
2020年 | 11篇 |
2019年 | 12篇 |
2018年 | 18篇 |
2017年 | 18篇 |
2016年 | 17篇 |
2015年 | 19篇 |
2014年 | 21篇 |
2013年 | 45篇 |
2012年 | 29篇 |
2011年 | 49篇 |
2010年 | 16篇 |
2009年 | 9篇 |
2008年 | 27篇 |
2007年 | 22篇 |
2006年 | 15篇 |
2005年 | 11篇 |
2004年 | 11篇 |
2003年 | 5篇 |
2002年 | 8篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1975年 | 1篇 |
排序方式: 共有418条查询结果,搜索用时 10 毫秒
71.
Figen Seymen Youn Jung Kim Ye Ji Lee Jenny Kang Tak-Heun Kim Hwajung Choi Mine Koruyucu Yelda Kasimoglu Elif Bahar Tuna Koray Gencay Teo Jeon Shin Hong-Keun Hyun Young-Jae Kim Sang-Hoon Lee Zang Hee Lee Hong Zhang Jan C-C. Hu James P. Simmer Eui-Sic Cho Jung-Wook Kim 《American journal of human genetics》2016,99(5):1199-1205
72.
Bilal A. Zargar Mubashir H. Masoodi Bahar Ahmed Khan Seema Akbar 《Phytochemistry letters》2013,6(2):261-266
Paeonia emodi (Peony) is a well known Himalayan medicinal plant used in the treatment of hypertension, palpitations, asthma, uterine diseases, colic, bilious obstructions and has also been used as an anticoagulant. Many of these ethnomedicinal properties have been experimentally proven in different animal models. The present work reviews the ethnopharmacology, therapeutic potential and phytochemistry of P. emodi. Different classes of natural products like triterpenoids, monoterpenoids, phenolics and tannins have been isolated from the species. These compounds possess wide therapeutic profile like cardiovascular and airway relaxant, lipoxygenase and β-Glucuronidase inhibitory and free radical scavenging properties. 相似文献
73.
74.
Bahar M Deng Y Zhu X He S Pandharkar T Drew ME Navarro-Vázquez A Anklin C Gil RR Doskotch RW Werbovetz KA Kinghorn AD 《Bioorganic & medicinal chemistry letters》2011,21(9):2606-2610
Treatment of diseases such as African sleeping sickness and leishmaniasis often depends on relatively expensive or toxic drugs, and resistance to current chemotherapeutics is an issue in treating these diseases and malaria. In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model. Since the synthetic starting material, berberine hemisulfate, is inexpensive, 8,8-dialkyl-substituted analogues of berberine may lead to a new class of affordable antiprotozoal compounds. 相似文献
75.
Penetration into membrane of amino‐terminal region of SecA when associated with SecYEG in active complexes 下载免费PDF全文
Bahar T. Findik Virginia F. Smith Linda L. Randall 《Protein science : a publication of the Protein Society》2018,27(3):681-691
The general secretory (Sec) system of Escherichia coli translocates both periplasmic and outer membrane proteins through the cytoplasmic membrane. The pathway through the membrane is provided by a highly conserved translocon, which in E. coli comprises two heterotrimeric integral membrane complexes, SecY, SecE, and SecG (SecYEG), and SecD, SecF, and YajC (SecDF/YajC). SecA is an associated ATPase that is essential to the function of the Sec system. SecA plays two roles, it targets precursors to the translocon with the help of SecB and it provides energy via hydrolysis of ATP. SecA exists both free in the cytoplasm and integrally membrane associated. Here we describe details of association of the amino‐terminal region of SecA with membrane. We use site‐directed spin labelling and electron paramagnetic resonance spectroscopy to show that when SecA is co‐assembled into lipids with SecYEG to yield highly active translocons, the N‐terminal region of SecA penetrates the membrane and lies at the interface between the polar and the hydrophobic regions, parallel to the plane of the membrane at a depth of approximately 5 Å. When SecA is bound to SecYEG, preassembled into proteoliposomes, or nonspecifically bound to lipids in the absence of SecYEG, the N‐terminal region penetrates more deeply (8 Å). Implications of partitioning of the SecA N‐terminal region into lipids on the complex between SecB carrying a precursor and SecA are discussed. 相似文献
76.
The aerial parts of Crotalaria emarginella Vatke (Leguminosae) has afforded two triterpenes, characterized as 3alpha-hydroxy-arbor-12-ene-28-carboxylic acid, designated as crotalic acid (1), and 2beta,3beta,21-trihydroxy-arbor-12-ene-29-carboxylic acid, designated as emarginellic acid (2). The structures of the isolated products were elucidated on the basis of spectral and chemical studies. On screening the biological activity, the crotalic acid (1) exhibited a significant anti-inflammatory activity (dose: 10mg/kg), which showed 53% inhibitory effect. Whereas, the standard oxyphenyl butazone (100mg/kg) exhibited 69% inhibition with respect to carrageenan (0.05ml, 1%) used to cause inflammation in rat paw method. In addition, it also showed anti-hepatotoxic activity by 13-30% with respect to standard silybon-70 (35-57%) against CCl(4) induced toxicity in Wistar rats. 相似文献
77.
Narzt Marie-Sophie Kremslehner Christopher Golabi Bahar Nagelreiter Ionela-Mariana Malikovic Jovana Hussein Ahmed M. Plasenzotti Roberto Korz Volker Lubec Gert Gruber Florian Lubec Jana 《Amino acids》2022,54(9):1311-1326
Amino Acids - Loss of cognitive function is a typical consequence of aging in humans and rodents. The extent of decline in spatial memory performance of rats, assessed by a hole-board test, reaches... 相似文献
78.
Sharafi H Rahimi R 《Journal of strength and conditioning research / National Strength & Conditioning Association》2012,26(4):1142-1148
Apoptosis is a programmed cell death that has been demonstrated in human and animal studies and plays an essential role to remove injured cells after acute strenuous exercise. Protein p53 plays important roles in regulating apoptosis via mitochondrial pathway. Therefore, the aims of this study were to determine the effects of acute resistance exercise (RE) on serum p53, caspase-9, and caspase-3, markers of apoptosis, and whether resistance training status influences the magnitude of the RE-induced apoptosis. Nine resistance-trained (RT) (age, 22.37 ± 1.99 years; height, 174 ± 5.04 cm; body weight, 71.32 ± 5.57 kg; and body mass index [BMI] 23.58 ± 2.05 kg·m(-2)) and 9 untrained (UT) college-age men (age, 22.25 ± 2.13 years; height, 171 ± 3.4 cm; body weight, 68.45 ± 3.23 kg; and BMI, 23.41 ± 1.08 kg·m(-2)) volunteered to participate in this study. Resistance-trained and UT men completed an RE bout consisting of 4 sets of 6 exercise at 80% of 1 repetition maximum until failure. Serum levels of p53, caspase-9, and caspase-3 were examined at preexercise (pre), immediately post (IP), 3 hours post (3 hours post), and 24 hours post RE (24 hours post). In UT, serum levels of p53, caspase-9, and caspase-3 were significantly increased at IP compared with RT. However, plasma insulin-like growth factor 1 level was higher for RT compared with UT at IP. Collectively, our data suggest the role of p53 in regulating apoptosis through mitochondrial pathway as measured by caspase-9 and caspase-3 after acute RE in UT. Our results also revealed that regular RT alters apoptosis biomarkers, especially the intrinsic pathway of apoptosis. 相似文献
79.
Mahbub Khandaker Rayhan Bahar Md Mezbaul Labbate Maurizio Krishnan Kannan Andrews Stuart Naidu Ravi Megharaj Mallavarapu 《Applied microbiology and biotechnology》2017,101(3):963-976
Applied Microbiology and Biotechnology - Contamination of land and water caused by heavy metal mercury (Hg) poses a serious threat to biota worldwide. The seriousness of toxicity of this neurotoxin... 相似文献
80.