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排序方式: 共有571条查询结果,搜索用时 156 毫秒
21.
Plasmonics - In this paper, we propose an ultra-compact high-speed electro-optical modulator with extremely low energy consumption based on silicon-polymer-metal hybrid plasmonic waveguide. Spatial... 相似文献
22.
Babak Sharifimajd Carl-Johan Thore Jonas Stålhand 《Biomechanics and modeling in mechanobiology》2016,15(3):497-510
Contractions of uterine smooth muscle cells consist of a chain of physiological processes. These contractions provide the required force to expel the fetus from the uterus. The inclusion of these physiological processes is, therefore, imperative when studying uterine contractions. In this study, an electro-chemo-mechanical model to replicate the excitation, activation, and contraction of uterine smooth muscle cells is developed. The presented modeling strategy enables efficient integration of knowledge about physiological processes at the cellular level to the organ level. The model is implemented in a three-dimensional finite element setting to simulate uterus contraction during labor in response to electrical discharges generated by pacemaker cells and propagated within the myometrium via gap junctions. Important clinical factors, such as uterine electrical activity and intrauterine pressure, are predicted using this simulation. The predictions are in agreement with clinically measured data reported in the literature. A parameter study is also carried out to investigate the impact of physiologically related parameters on the uterine contractility. 相似文献
23.
Sadeghnezhad Ehsan Sharifi Mohsen Zare-maivan Hassan Khorsand Babak Zahiri Javad 《Journal of plant biochemistry and biotechnology.》2019,28(2):230-243
Journal of Plant Biochemistry and Biotechnology - Plant cell balances energy consumption for its different biological processes under oxidative circumstances. The aim of the present study is to... 相似文献
24.
Masoud Ghiasian Forough Khamisabadi Nejat Kheiripour Manouchehr Karami Rasool Haddadi Ali Ghaleiha Babak Taghvaei Seyed Sajad Oliaie Mohammadjavad Salehi Pouria Samadi Akram Ranjbar 《Journal of biochemical and molecular toxicology》2019,33(12)
Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the nerve cells, resulting in neurological disorders. Oxidative stress, free radicals, and neuritis have important roles in MS pathogenesis. Here, we aim to evaluate the effect of crocin on inflammatory markers, oxidative damage, and deoxyribonucleic acid (DNA) damage in the blood of patients with MS. A total of 40 patients were divided into two groups, drug and placebo‐treated groups, using random assignment. Participants of the intervention and control groups received two crocin capsules or placebo per day for 28 days, respectively. Findings revealed a significant decrease in the level of important pathogenic factors in MS, including lipid peroxidation, DNA damage, tumor necrosis factor‐alpha, and interleukin 17 as well as a significant increase in the total antioxidant capacity in the serum of patients treated with crocin compared with the placebo group. Our results suggest the beneficial and therapeutic effects of crocin in MS. 相似文献
25.
Anwar Fathollahi Saeed Aslani Ahmadreza Jamshidi Mahdi Mahmoudi 《Journal of cellular physiology》2019,234(8):12309-12324
Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an absolute consequence of joint mechanical use (wear and tear); rather recent data demonstrate the pivotal role of inflammatory mediators in the development and progression of this disease. This multifactorial disease results from several environmental and inherited factors. Genetic cannot solely explain all the contribution share of inheritance and, this way, it is speculated that epigenetics can play a role, too. Moreover, environmental factors can induce local epigenetic changes. The epigenetic contribution to OA pathogenesis occurs at all of its levels, DNA methylation, histone modification, microRNA, and long noncoding RNA. In fact, during early phases of OA pathogenesis, environmental factors employ epigenetic mechanisms to provide a positive feedback for the OA-related pathogenic mechanisms and pathways with an ultimate outcome of a well-established clinical OA. These epigenetic changes stay during clinical disease and prevent the body natural healing and regenerative processes to work properly, resulting in an incurable disease condition. In this review article, we aimed to have an overview on the studies performed with regard to understanding the role of epigenetics in the etiopathogenesis of OA and highlighted the importance of such kind of regulatory mechanisms within this context. 相似文献
26.
Sahar Khorasani Mahmoud Mahmoudi Mahmoud Reza Kalantari Fahimeh Lavi Arab Seyed-Alireza Esmaeili Fatemeh Mardani Nafiseh Tabasi Maryam Rastin 《Journal of cellular physiology》2019,234(6):9778-9786
Regulatory T cells (Tregs) play an indispensable role in the control of immune responses and induction of peripheral tolerance. Dysregulation of Tregs is involved in the pathogenesis of systemic lupus erythematosus (SLE). Tolerogenic probiotics have shown beneficial effects in the control of autoimmune diseases. We evaluated the prophylactic and therapeutic effects of Lactobacillus delbrueckii and Lactobacillus rhamnosus on Tregs and their related molecules in pristane-induced lupus mice model. Fifty-four female BALB/c mice (3–5 weeks) were randomly divided into nine groups. Lupus was induced in all groups using pristane. Prophylactic groups were treated from Day 0 (at the time of pristane injection) and treatment groups were treated 2 months later with L. rhamnosus, L. delbrueckii, mix of both probiotics, and prednisolone. One group was considered as SLE-induced control group without any treatment. Presence of antinuclear antibodies (ANA), antidouble-stranded DNA (anti-dsDNA), antiribonucleoprotein (anti-RNP), proteinuria, and serum level of creatinine, urea, the expression of forkhead box P3 (Foxp3), interleukin 6 (IL-6), IL-10, transforming growth factor β, and the number of Tregs were determined. SLE induction by pristane led to the formation of lipogranuloma, presence of ANA, anti-dsDNA, and anti-RNP. Probiotics consumption decreased the level of lipogranuloma, ANA, and anti-dsDNA. In addition, in probiotics receiving groups, Tregs and the expression level of Foxp3 increased, while IL-6 decreased. The effect of probiotics in the prophylactic group was more prominent. The results may indicate the effectiveness of L. delbrueckii and L. rhamnosus in the enhancement of Tregs and the decrease of inflammatory cytokines and disease severity in SLE-induced mice. 相似文献
27.
Meghdad Abdollahpour-Alitappeh Majid Lotfinia Tohid Gharibi Jalal Mardaneh Behrouz Farhadihosseinabadi Pegah Larki Babak Faghfourian Koushan Sineh Sepehr Kazem Abbaszadeh-Goudarzi Ghasem Abbaszadeh-Goudarzi Behrooz Johari Mohammad Reza Zali Nader Bagheri 《Journal of cellular physiology》2019,234(5):5628-5642
Targeted delivery of therapeutic molecules into cancer cells is considered as a promising strategy to tackle cancer. Antibody–drug conjugates (ADCs), in which a monoclonal antibody (mAb) is conjugated to biologically active drugs through chemical linkers, have emerged as a promising class of anticancer treatment agents, being one of the fastest growing fields in cancer therapy. The failure of early ADCs led researchers to explore strategies to develop more effective and improved ADCs with lower levels of unconjugated mAbs and more-stable linkers between the drug and the antibody, which show improved pharmacokinetic properties, therapeutic indexes, and safety profiles. Such improvements resulted in the US Food and Drug Administration approvals of brentuximab vedotin, trastuzumab emtansine, and, more recently, inotuzumab ozogamicin. In addition, recent clinical outcomes have sparked additional interest, which leads to the dramatically increased number of ADCs in clinical development. The present review explores ADCs, their main characteristics, and new research developments, as well as discusses strategies for the selection of the most appropriate target antigens, mAbs, cytotoxic drugs, linkers, and conjugation chemistries. 相似文献
28.
Darroudi Susan Saberi-Karimian Maryam Tayefi Maryam Tayefi Batool Khashyarmanesh Zahra Fereydouni Narges Haghighi Hamideh Moalemzadeh Mahmoudi Ali Asghar Kharazmi-Khorassani Jasmine Gonoodi Kayhan Esmaeili Habibolah Mohammadpour Amir Hooshang Ferns Gordon A. Ghayour-Mobarhan Majid 《Biological trace element research》2019,190(1):38-44
Biological Trace Element Research - The prevalence of hypertension (HTN) is increasing globally. It has been shown that there is an association between micronutrient deficiency and HTN. In the... 相似文献
29.
30.
Michelle P. Clark Thao Huynh Shringar Rao Liana Mackiewicz Hugh Mason Shahla Romal Michael D. Stutz Sang H. Ahn Linda Earnest Vitina Sozzi Margaret Littlejohn Bang M. Tran Norbert Wiedemann Elizabeth Vincan Joseph Torresi Hans J. Netter Tokameh Mahmoudi Peter Revill Marc Pellegrini Gregor Ebert 《Cell death & disease》2021,12(7)
A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individuals to reduce their risk of developing liver cancer. A strategy to deliver such a therapy could utilize the ability to target and promote apoptosis of infected hepatocytes. Presently there is no clinically relevant strategy that has been shown to effectively remove persistent episomal covalently closed circular HBV DNA (cccDNA) from the nucleus of hepatocytes. We used linearized single genome length HBV DNA of various genotypes to establish a cccDNA-like reservoir in immunocompetent mice and showed that clinical-stage orally administered drugs that antagonize the function of cellular inhibitor of apoptosis proteins can eliminate HBV replication and episomal HBV genome in the liver. Primary human liver organoid models were used to confirm the clinical relevance of these results. This study underscores a clinically tenable strategy for the potential elimination of chronic HBV reservoirs in patients.Subject terms: Target validation, Hepatitis B, Preclinical research, Translational research 相似文献