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41.
Background
MicroRNAs (miRNAs) are oligoribonucleotides with an important role in regulation of gene expression at the level of translation. Despite imperfect target complementarity, they can also significantly reduce mRNA levels. The validity of miRNA target gene predictions is difficult to assess at the protein level. We sought, therefore, to determine whether a general lowering of predicted target gene mRNA expression by endogenous miRNAs was detectable within microarray gene expression profiles. 相似文献42.
Ursum J Nielen MM van Schaardenburg D van der Horst AR van de Stadt RJ Dijkmans BA Hamann D 《Arthritis research & therapy》2008,10(1):R12
Introduction
The aim of our study was to investigate the association between arthritic disease activity and antibodies to mutated citrullinated vimentin (anti-MCV), because such a relation has been suggested. 相似文献43.
Major achievements have been reached in the treatment of rheumatoid arthritis during past decades due to the recognition of
methotrexate as an anchor drug for treatment of rheumatoid arthritis, due to the notion of a treatment window of opportunity
in patients with recent-onset rheumatoid arthritis necessitating early aggressive therapy, due to the development of biologics
and due to remission as a treatment target. Most biologics have a much faster onset of action than synthetic disease-modifying
anti-rheumatic drugs, but presently there is no convincing evidence that biologic drugs have a superior clinical efficacy
in comparison with the synthetic drugs. Biologics are, however, accompanied by less radiological deterioration. 相似文献
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Shahram?SadeghiEmail author Mohammadrezaalavian?Ghavanini Alireza?Ashraf Peyman?Jafari 《BMC neurology》2004,4(1):11
Background
central loop of the gastrocnemius-soleus H-reflex latency (Tc) that looks promising in the diagnosis of S1 radiculopathy; has been investigated in a few studies and only two of them have focused on the constitutional factors affecting it. Although leg length has been shown to contribute to the Tc, the role of age is controversial. More confusing, none of the previously performed studies have used strict criteria to rule out subclinical neuropathy, so the results could be misleading. This study has been performed to determine the influence of leg length and age on Tc among a carefully selected group of healthy volunteers. 相似文献49.
Curtin AC De Angelis M Cipriani M Corbo MR McSweeney PL Gobbetti M 《Journal of applied microbiology》2001,91(2):312-321
AIMS: To screen the cystathionine lyase and L-methionine aminotransferase activities of cheese-related bacteria (lactococci, non-starter lactobacilli and smear bacteria) and to determine the individual and interactive effects of temperature, pH and NaCl concentration on selected enzyme activities. METHODS AND RESULTS: A subcellular fractionation protocol and specific enzyme assays were used, and a quadratic response surface methodology was applied. The majority of the strains, 21 of 33, had detectable cystathionine lyase activity which differed in the specificity. Aminotransferase activity on L-methionine was observed in only three strains. The cystathionine lyase activities of Lactobacillus reuteri DSM20016, Lactococcus lactis subsp. cremoris MG1363, Brevibacterium linens 10 and Corynebacterium ammoniagenes 8 and the L-methionine aminotransferase activity of Lact. reuteri DSM20016 had temperature and pH optima of 30-45 degrees C, and 7.5-8.0, respectively. As shown by the quadratic response surface methodology these enzymes retained activities in the range of temperature, pH and NaCl concentration which characterized the cheeses from which the bacteria originated. CONCLUSION: The enzyme activities may have a role in flavour development during cheese ripening. SIGNIFICANCE AND IMPACT OF THE STUDY: The findings of this work contribute to the knowledge about the amino acid catabolic enzymes in order to improve cheese ripening. 相似文献
50.
Gianmarco M Balestra Egbert G Mik Otto Eerbeek Patricia AC Specht Willem J van der Laarse Coert J Zuurbier 《Respiratory research》2015,16(1)