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Aysel Aricioglu Meral Bozkurt Barbaros Balabanli Mehtap Kilinç N. Kemal Nazaroglu Nurten Türközkan 《Biological trace element research》2001,80(2):175-179
Acute ultraviolet-B (UV-B) irradiation is known to act as an initiator in the formation of reactive oxygen species. These
oxygen products are highly reactive and they are able to cause irreversible damage to cellular components. Oxygen free radicals
are normally neutralized by very efficient systems in the body. These include antioxidant enzymes like superoxide dismutase
(SOD). In a healthy subject, there is a balance between free radicals and the levels of antioxidants. In some pathological
conditions such as oxidative stress, the level of antioxidants is significantly reduced. The skin contains relatively high
levels of zinc (Zn), an essential element known to be a cofactor in some metabolic pathways. Zinc has also been reported to
have antioxidant properties.
In the present study, we investigated the effect of ginkgo biloba extract (Gbe), a potent free-radical scavenger, on UV-B-irradiated
skin by measuring SOD activity and Zn levels in the skin, before and after treatment. The SOD activity was decreased after
UV-B exposure, in comparison with the control group (p<0.05). After Gbe treatment, the SOD activity increased (p<0.05) as compared with the untreated UV-B irradiated group. The Zn levels changed in the same pattern as the SOD activity
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