排序方式: 共有97条查询结果,搜索用时 46 毫秒
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Luke A. Smith MSc Jaedon D. Bem MSc Xiaojing Lv PhD Antonio Lauto PhD Ashour Sliow PhD Zhiyuan Ma MD David A. Mahns PhD Carolyn Berryman PhD Mark R. Hutchinson PhD Christophe Fumeaux PhD Giuseppe C. Tettamanzi PhD 《Bioelectromagnetics》2023,44(7-8):181-191
Electric-field stimulation of neuronal activity can be used to improve the speed of regeneration for severed and damaged nerves. Most techniques, however, require invasive electronic circuitry which can be uncomfortable for the patient and can damage surrounding tissue. A recently suggested technique uses a graft-antenna—a metal ring wrapped around the damaged nerve—powered by an external magnetic stimulation device. This technique requires no electrodes and internal circuitry with leads across the skin boundary or internal power, since all power is provided wirelessly. This paper examines the microscopic basic mechanisms that allow the magnetic stimulation device to cause neural activation via the graft-antenna. A computational model of the system was created and used to find that under magnetic stimulation, diverging electric fields appear at the metal ring's edges. If the magnetic stimulation is sufficient, the gradients of these fields can trigger neural activation in the nerve. In-vivo measurements were also performed on rat sciatic nerves to support the modeling finding that direct contact between the antenna and the nerve ensures neural activation given sufficient magnetic stimulation. Simulations also showed that the presence of a thin gap between the graft-antenna and the nerve does not preclude neural activation but does reduce its efficacy. 相似文献
73.
Evaluation of BAG3 levels in healthy subjects,hypertensive patients,and hypertensive diabetic patients
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74.
Sirmali M Uz E Sirmali R Kilbaş A Yilmaz HR Altuntaş I Naziroğlu M Delibaş N Vural H 《Biological trace element research》2007,118(1):43-52
The aim of this study was to investigate the protective effects of erdosteine and vitamins C and E (VCE) on the lungs after
performing hind limb ischemia–reperfusion (I/R) by assessing oxidative stress, plasma copper (Cu), and zinc (Zn) analysis.
The animals were divided randomly into four groups as nine rats each as follows: control, I/R, I/R plus erdosteine, and I/R
plus VCE combination. I/R period for 60 min was performed on the both hind limbs of all the rats in the groups of I/R, erdosteine
with I/R, VCE with I/R allowing 120 min of reperfusion. The animals received orally erdosteine one time in a day and 3 days
before I/R in the erdosteine group. In the VCE group, the animals VCE combination received one time in a day and 3 days before
I/R, although placebo was given to control and I/R group animals. Lung lipid peroxidation (malondialdehyde [MDA]) level, superoxide
dismutase (SOD), and catalase activities were increased, although lung glutathione (GSH) and plasma Zn levels decreased in
I/R group in lung tissue compared with the control group. Serum MDA level, creatine kinase, and lactate dehydrogenase activities
were increased in I/R group compared with the control. Lung MDA and plasma Zn levels and lung SOD activity were decreased
by erdosteine administration, whereas lung GSH levels after I/R increased. The plasma Zn levels and lung SOD activity were
decreased by VCE administration, although the plasma Cu and lung GSH levels increased after I/R. In conclusion, erdosteine
has an antioxidant role on the values in the rat model, and it has more protective affect than in VCE in attenuating I/R-induced
lung injury in rats. 相似文献
75.
Gokcimen A Kocak A Kilbas S Bayram D Kilbas A Cim A Kockar C Kutluhan S 《Molecular and cellular biochemistry》2007,296(1-2):159-164
N
G-Nitro-l-arginine methyl ester hydrochloride (L-NAME) is a non-specific nitric oxide (NO) inhibitor and it has been used to eliminate
the role of NO in many studies like animal models for hypertension. In this study, we aimed to investigate whether lisinopril
treatment has any biochemical and/or histopathological effect on rat liver tissue in a L-NAME-induced hypertension model.
Forty-eight 6-weeks-old male Spraque–Dawley rats were used in the study. The animals used in the study were randomly divided
into four equal groups. To induce hypertension, L-NAME was added to drinking water at a concentration of 600 mg/l and each
rat was given 75 mg/kg/day of L-NAME for 6 weeks. Tail cuff systolic blood pressure (SBP) was measured at first, third, and
sixth weeks. There was a significant difference between the experiment groups and controls. In only lisinopril given and L-NAME
plus lisinopril administered groups, each rat was given 10 mg/kg of lisinopril for 6 weeks. At the end of the study, the animals
were sacrificed. Blood and tissue samples were collected for biochemical and histopathological analysis. It has been observed
that mean NO level was significantly decreased in L-NAME given group (p<0.05). Mean ALT levels were significantly increased in lisinopril and L-NAME plus lisinopril given groups, when compared
with the control group (p<0.05). AST levels were in normal range in all groups (p>0.05). Hepatocyte degeneration was prominent in lisinopril given group, whereas mononuclear cell infiltration was significant
in L-NAME given groups. Although the beneficial effects in L-NAME-induced hypertension treatment, lisinopril can lead to some
unexpected results like hepatocyte degeneration, serum enzyme level elevation, and slight mononuclear cell infiltration. 相似文献
76.
Kumanan Wilson MD MSc 《CMAJ》2007,177(11):1387-1389
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Selen Serel Arslan Özgü İnal Numan Demir Merih Seval Ölmez Aynur Ayşe Karaduman 《Somatosensory & motor research》2017,34(2):92-95
Purpose To investigate if chewing side preference (CSP) can be used as an indicator of hemispheric laterality in healthy adults. Materials and methods Seventy-five individuals were included. The visual analogue scale (VAS) was used to determine CSP and laterality test for preferred peripheral organs. Results Significant correlation between CSP and hand, foot, ear, and eye side preference was found (r?=?.41, p?.001; r?=?.34, p?=?.003; r?=?.35, p?=?.03; r?=?.36, p?=?.002). Conclusion Besides peripheral organs, the CSP can also be used in determination of hemispheric lateralization. 相似文献
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Regulatory effect of resveratrol and prednisolone on MDR1 gene expression in acute lymphoblastic leukemia cell line (CCRF‐CEM): An epigenetic perspective
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80.