排序方式: 共有27条查询结果,搜索用时 15 毫秒
11.
V Aranapakam J D Albright G T Grosu P S Chan J Coupet T Saunders X Ru H Mazandarani 《Bioorganic & medicinal chemistry letters》1999,9(13):1733-1736
Synthesis and structure-activity relationships (SAR) of arginine vasopressin receptor (AVP) antagonists are described. Potent and orally active compounds are prepared when tricyclic 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine moiety in VPA-985 1 is replaced with a compound 7 or 12. 相似文献
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Aydin Raei Sadigh Aynaz Mihanfar Amir Fattahi Zeinab Latifi Maryam Akbarzadeh Hamed Hajipour Zahra Bahrami-asl Aliyeh Ghasemzadeh Kobra Hamdi Hamid Reza Nejabati Mohammad Nouri 《Journal of cellular biochemistry》2019,120(12):19229-19244
It is well known that embryo implantation is a critical process in which embryo should be able to reach and attach to endometrium. Until now, various types of factors are involved in the regulation of this process. S100 proteins are calcium-binding proteins, which have vital roles in embryo implantation and have been considered as possible candidate markers for endometrial receptivity. However, studies regarding mode of actions of these proteins are scarce and more mechanistic insights are needed to clarify exact roles of each one of the S100 protein family. Understanding of function of these proteins in different compartments, stages, and phases of endometrium, could pave the way for conducting studies regarding the therapeutic significance of these proteins in some disorders such as recurrent implantation failure. In this review, we outlined roles and possible underlying mechanisms of S100 protein family in embryo implantation. 相似文献
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Welmaker GS Nelson JA Sabalski JE Sabb AL Potoski JR Graziano D Kagan M Coupet J Dunlop J Mazandarani H Rosenzweig-Lipson S Sukoff S Zhang Y 《Bioorganic & medicinal chemistry letters》2000,10(17):1991-1994
A series of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines was shown to exhibit 5-HT2C agonist binding and functional activity. Compound 21R inhibited food intake over 2 h in fasted, male Sprague Dawley rats with ED50 values of 2 mg/kg (i.p.) and 10 mg/kg (p.o.). 相似文献
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Sum FW Dusza J Santos ED Grosu G Reich M Du X Albright JD Chan P Coupet J Ru X Mazandarani H Saunders T 《Bioorganic & medicinal chemistry letters》2003,13(13):2195-2198
Novel tricyclic benzazepine derivatives were synthesized as arginine vasopressin (AVP) antagonists. Several tricyclic compounds showed potent antagonistic activity in rat AVP receptors V(1a) and V(2). Derivatives containing pyrrolo-tricyclic amines, 13i-k, 30, and 31 also showed selectivity for the V(2) receptor. 相似文献
15.
Venkatesan AM Grosu GT Failli AA Chan PS Coupet J Saunders T Mazandarani H Ru X 《Bioorganic & medicinal chemistry letters》2005,15(22):5003-5006
Synthesis and structure-activity relationships (SAR) of arginine vasopressin (AVP) receptor modulators are described. Potent and selective compounds are prepared when the amide linkage connecting rings A and B of VPA-985 is replaced with a bond, CO, -O-, -S-, or -SO2- bond. 相似文献
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Aynaz Mihanfar Hamid Reza Nejabati Amir Fattahi Zeinab Latifi Masoud Pezeshkian Abbas Afrasiabi Naser Safaie Ahmad Reza Jodati Mohammad Nouri 《Journal of cellular physiology》2019,234(3):2083-2094
Coronary artery disease (CAD) is a common cause of morbidity and mortality worldwide. Atherosclerotic plaques, as a hallmark of CAD, cause chronic narrowing of coronary arteries over time and could also result in acute myocardial infarction (AMI). The standard treatments for ameliorating AMI are reperfusion strategies, which paradoxically result in ischemic reperfusion (I/R) injury. Sphingosine 1 phosphate (S1P), as a potent lysophospholipid, plays an important role in various organs, including immune and cardiovascular systems. In addition, high-density lipoprotein, as a negative predictor of atherosclerosis and CAD, is a major carrier of S1P in blood circulation. S1P mediates its effects through binding to specific G protein-coupled receptors, and its signaling contributes to a variety of responses, including cardiac inflammation, dysfunction, and I/R injury protection. In this review, we will focus on the role of S1P in CAD and I/R injury as a potential therapeutic target. 相似文献
18.
Anesthesia of wild female Persian sturgeon,Acipenser persicus (Borodin, 1897) breeders during controlled propagation: effects on hematological parameters,stress response and reproductive performance 下载免费PDF全文
M. Mazandarani S. M. Hoseini R. Shahriari 《Zeitschrift fur angewandte Ichthyologie》2015,31(6):997-1001
This study examined the effects of anesthesia on the hematological and biochemical parameters as well as the reproductive performance of wild female Persian sturgeon, Acipenser persicus, during controlled spawning. Fourteen mature females were divided into two groups: ‘anesthetized’ and ‘non‐anesthetized’. All activities including transportation, catheterizing and handling were performed with both groups: (i) under anesthesia (150 ppm clove oil), and (ii) without anesthesia. After 10 days storage and handling, blood samples were taken from all fish after anesthesia. No significant differences were found in the reproductive performance of either group. However, differences were found in the hematological parameters, with values being significantly higher in the non‐anesthetized group, including neutrophils (34.36 ± 6.33% vs 23.63 ± 5.22%), monocytes (2.84 ± 1.70% vs 1.27 ± 0.64%), mean corpuscular volume (321.3 ± 39.40 pg vs 228.0 ± 24.46 pg) and mean corpuscular hemoglobin (106.9 ± 15.70 fl vs 76.50 ± 7.50 fl). Significantly lower values were found in the non‐anesthetized group for lymphocytes (60.68 ± 7.25% vs 73.54 ± 4.80%), Hb (4.62 ± 0.74 mg dl?1 vs 6.28 ± 1.21 mg dl?1), Hct (13.86 ± 1.76% vs 18.84 ± 3.85%), red blood cell (0.43 ± 0.05 cell mm?3 vs 0.85 ± 0.13 × 106 cell mm?3) and white blood cell (22 403 ± 2240 cell mm?3 vs 35 318 ± 3084 cell mm?3). The non‐anesthetized fish had significantly higher cortisol levels compared to the anesthetized group (62.33 ± 8.85 ng ml?1 vs 46.12 ± 8.07 ng ml?1). There was no difference in plasma glucose levels between groups. It is concluded that the use of clove oil as an anesthetic is suitable for handling of wild female Persian sturgeon in controlled propagation programmes. However, further research is needed to determine a standardized protocol for the safe application of anesthesia for use in sturgeons in general. 相似文献
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V Aranapakam J D Albright G T Grosu E G Delos Santos P S Chan J Coupet X Ru T Saunders H Mazandarani 《Bioorganic & medicinal chemistry letters》1999,9(13):1737-1740
Synthesis and structure-activity relationships (SAR) of orally active arginine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A of VPA-985 (1) is replaced with a 3-pyridinyl unit (2b). 相似文献
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Javidnia Javad Ghotbi Zahra Ghojoghi Aynaz Solhjoo Kavous Alshahni Mohamed Mahdi Jeddi Seyed Ali Ahmadi Bahram Nouripour-Sisakht Sadegh Ansari Saham Shokoohi Gholamreza 《Mycopathologia》2022,187(2-3):225-233
Mycopathologia - Otomycosis is a superficial infection of the external ear caused by fungal pathogens. The genera Aspergillus and Candida are considered the main fungal causative agents, with the... 相似文献