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排序方式: 共有211条查询结果,搜索用时 15 毫秒
81.
Akçakaya P Azeroglu B Even I Ates O Turker H Ongen G Topal-Sarikaya A 《Molecular biology reports》2012,39(4):5009-5016
Sarcoidosis (SA) is an immune-mediated multisystemic disorder of unknown etiology characterized by the accumulation of lymphocytes,
mononuclear phagocytes and epithelioid cell granulomas involved in different organs and tissues. The belief that genetics
contribute to SA etiology is supported by twin studies, disease clustering in families and racial differences in incidence
rates. Involvements of SLC11A1 in macrophage function and activation, makes it an attractive candidate gene for immune-mediated and infectious diseases.
We investigated the association between SA and four polymorphisms of the SLC11A1 gene, including a single nucleotide change in intron 4 (INT4); a nonconservative single-base substitution at codon 543 (D543N);
a TGTG deletion in the 3′ untranslated region; and the functional (GT)n repeat polymorphism in the 5′ region, in 95 Turkish SA patients and 150 healthy controls, by using amplification refractory
mutation system–polymerase chain reaction and sequencing. We found significant association between SA and INT4 G/C allele
frequency (P = 0.0000; odds ratio 2.75; 95% confidence interval 1.68–4.52) and 5′(GT)n allele 2/3 frequency (P = 0.0000; odds ratio 2.69; 95% confidence interval 1.61–4.47) suggesting that SLC11A1 might be a plausible candidate gene for SA. 相似文献
82.
Even Tjørve 《Journal of Biogeography》2012,39(4):629-639
Aim Studies have typically employed species–area relationships (SARs) from sample areas to fit either the power relationship or the logarithmic (exponential) relationship. However, the plots from empirical data often fall between these models. This article proposes two complementary and hybrid models as solutions to the controversy regarding which model best fits sample‐area SARs. Methods The two models are and , where SA is number of species in an area, A, where z, b, c1 and c2 are predetermined parameters found by calculation, and where d and n are parameters to be fitted. The number of parameters is reduced from six to two by fixing the model at either end of the scale window of the data set, a step that is justified by the condition that the error or the bias, or both, in the first and the last data points is negligible. The new hybrid models as well as the power model and the logarithmic model are fitted to 10 data sets. Results The two proposed models fit well not only to Arrhenius’ and Gleason’s data sets, but also to the other six data sets. They also provide a good fit to data sets that follow a sigmoid (or triphasic) shape in log–log space and to data sets that do not fall between the power model and the logarithmic model. The log‐transformation of the dependent variable, S, does not affect the curve fit appreciably, although it enhances the performance of the new models somewhat. Main conclusions Sample‐area SARs have previously been shown to be convex upward, convex downward (concave), sigmoid and inverted sigmoid in log–log space. The new hybrid models describe successfully data sets with all these curve shapes, and should therefore produce good fits also to what are termed triphasic SARs. 相似文献
83.
Even PC Nadkarni NA 《American journal of physiology. Regulatory, integrative and comparative physiology》2012,303(5):R459-R476
In this article, we review some fundamentals of indirect calorimetry in mice and rats, and open the discussion on several debated aspects of the configuration and tuning of indirect calorimeters. On the particularly contested issue of adjustment of energy expenditure values for body size and body composition, we discuss several of the most used methods and their results when tested on a previously published set of data. We conclude that neither body weight (BW), exponents of BW, nor lean body mass (LBM) are sufficient. The best method involves fitting both LBM and fat mass (FM) as independent variables; for low sample sizes, the model LBM + 0.2 FM can be very effective. We also question the common calorimetry design that consists of measuring respiratory exchanges under free-feeding conditions in several cages simultaneously. This imposes large intervals between measures, and generally limits data analysis to mean 24 h or day-night values of energy expenditure. These are then generally compared with energy intake. However, we consider that, among other limitations, the measurements of Vo(2), Vco(2), and food intake are not precise enough to allow calculation of energy balance in the small 2-5% range that can induce significant long-term alterations of energy balance. In contrast, we suggest that it is necessary to work under conditions in which temperature is set at thermoneutrality, food intake totally controlled, activity precisely measured, and data acquisition performed at very high frequency to give access to the part of the respiratory exchanges that are due to activity. In these conditions, it is possible to quantify basal energy expenditure, energy expenditure associated with muscular work, and response to feeding or to any other metabolic challenge. This reveals defects in the control of energy metabolism that cannot be observed from measurements of total energy expenditure in free feeding individuals. 相似文献
84.
Effect of Precursor Solution Aging on the Crystallinity and Photovoltaic Performance of Perovskite Solar Cells
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Hsinhan Tsai Wanyi Nie Yen‐Hao Lin Jean Christophe Blancon Sergei Tretiak Jacky Even Gautam Gupta Pulickel M. Ajayan Aditya D. Mohite 《Liver Transplantation》2017,7(11)
Perovskite materials due to their exceptional photophysical properties are beginning to dominate the field of thin‐film optoelectronic devices. However, one of the primary challenges is the processing‐dependent variability in the properties, thus making it imperative to understand the origin of such variations. Here, it is discovered that the precursor solution aging time before it is cast into a thin film, is a subtle but a very important factor that dramatically affects the overall thin‐film formation and crystallinity and therein factors such as grain growth, phase purity, surface uniformity, trap state density, and overall solar cell performance. It is shown that progressive aging of the precursor promotes efficient formation of larger seeds after the fast nucleation of a large density of small seeds. The hot‐casting method then leads to the growth of large grains in uniform thin‐films with excellent crystallinity validated using scanning microscopy images and X‐ray diffraction patterns. The high‐quality films cast from aged solution is ideal for thin‐film photovoltaic device fabrication with reduced shunt current and good charge transport. This observation is a significant step toward achieving highly crystalline thin‐films with reliability in device performance and establishes the subtle but dramatic effect of solution aging before fabricating perovskite thin‐films. 相似文献
85.
Transcranial magnetic stimulation is a noninvasive way to produce an electric stimulation of the cerebral cortex. This stimulation results in many biological effects in the stimulated cortical zone and also at distant subcortical centers. Some of these effects are shared with antidepressants and electroconvulsive shocks. But some technical difficulties remain (e.g. to stimulate precisely the anatomic targets, in spite of interindividual variability) and stimulation protocols are in progression, which prevent a large use of TMS outside research labs. Clinical trials in depression show modest effects with resistant depressive episodes. The most important and lasting clinical effects of TMS seem to be the treatment of medication resistant auditive hallucinations in schizophrenia. 相似文献
86.
Habitat size and number in multi-habitat landscapes: a model approach based on species-area curves 总被引:1,自引:0,他引:1
Even Tjrve 《Ecography》2002,25(1):17-24
This paper discusses species diversity in simple multi-habitat environments. Its main purpose is to present simple mathematical and graphical models on how landscape patterns affect species numbers. The idea is to build models of species diversity in multi-habitat landscapes by combining species-area curves for different habitats. Predictions are made about how variables such as species richness and species overlap between habitats influence the proportion of the total landscape each habitat should constitute, and how many habitats it should be divided into in order to be able to sustain the maximal number of species. Habitat size and numbers are the only factors discussed here, not habitat spatial patterns. Among the predictions are: 1) where there are differences in species diversity between habitats, optimal landscape patterns contain larger proportions of species rich habitats. 2) Species overlap between habitats shifts the optimum further towards larger proportions of species rich habitat types. 3) Species overlap also shifts the optimum towards fewer habitat types. 4) Species diversity in landscapes with large species overlap is more resistant to changes in landscape (or reserve) size. This type of model approach can produce theories useful to nature and landscape management in general, and the design of nature reserves and national parks in particular. 相似文献
87.
88.
In litter-bearing mammals, the course of development of male and female fetuses is affected by the presence of other fetuses of the same or opposite sex located nearby within the uterus. The transport of testosterone between rat fetuses was examined by implanting a Silastic capsule containing [3H]testosterone into the amniotic sac of a fetus at either the ovarian or cervical end of a uterine horn on days 19 and 20 of pregnancy. The amount of testosterone that was recovered from the amniotic fluid of other fetuses 12 h later was determined. The amniotic fluid surrounding the adjacent fetus on the cervical side of the implanted fetus contained three times as much [3H]testosterone as did the adjacent fetus on the ovarian side, regardless of where in the uterus the implant was made. The movement of dye injected into the uterine lumen was towards the cervix. Intraluminal fluid movement may thus mediate the greater transport of [3H]testosterone towards the cervix than towards the ovary. Our findings support the hypothesis that transport of testosterone between fetuses occurs across the fetal membranes via diffusion, such that any fetus (male or female) located between male fetuses receives the greatest supplement of testosterone. 相似文献
89.
The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains. 总被引:23,自引:0,他引:23
The molecular chaperone BiP/GRP78 associates with various polypeptides in the endoplasmic reticulum, including immunoglobulin chains. We now show, using chemical cross-linking, that another endoplasmic reticulum stress protein, GRP94, associates with newly synthesized immunoglobulin light and heavy chains. We demonstrate the presence of ternary complexes composed of immunoglobulin chains, BiP and GRP94. Because both BiP and GRP94 associate far less with fully assembled immunoglobulin than with unassembled subunits, our data suggest that GRP94, like BiP, functions as a molecular chaperone. The presence of both BiP and GRP94 in the same complex further suggests that the two stress proteins work in concert during the folding and assembly of immunoglobulins. 相似文献
90.
Yeast strains sigma1278b and Harden and Young, which synthesize only an internal constitutive form of L-asparaginase, do not grow on D-asparagine, as a sole source of nitrogen, and whole cell suspensions of these strains do not hydrolyze D-asparagine. Strains X2180-A2 and D273-10B, which possess an externally active form of asparaginase, are able to grow slowly on D-asparagine, and nitrogen-starved suspensions of these strains exhibit high activity toward the D-isomer. Nitrogen starvation of strain X218O-A2 results in coordinate increase of D- and L-asparaginase activity; the specific activity observed for the D-isomer is approximately 20% greater than that observed for the L-isomer. It was observed, in studies with cell extracts, that hydrolysis of D-asparagine occurred only with extracts from nitrogen-starved cells of strains that synthesize the external form of asparaginase. Furthermore, the activity of the extracts toward the D-isomer was always higher than that observed with the L-isomer. A 400-fold purified preparation of external asparaginase from Saccharomyces cerevisiae X218U-A2 hydrolyzed D-asparagine with an apparent Km of 0.23 mM and a Vmax of 38.7 mumol/min per mg of protein. D-Asparagine was a competitive inhibitor of L-asparagine hydrolysis and the Ki determined for this inhibition was approximately equal to its Km. These data suggest that D-asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme. 相似文献